Catalog No.
YHN52501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
[Thr2-Gly19] & [Pro72-Cys85] & [Asn147-Tyr165] & [Ala250-Thr261] & [Gly283-Asn330]
Predicted molecular weight
28.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8TDU6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37, GPBAR1, TGR5
Bile acid-mediated gut-liver axis crosstalk: the role of nuclear receptor signaling in dynamic regulation of inflammatory networks., PMID:40458398
Pharmacological and physiological activation of TGR5 in the NTS lowers food intake by enhancing leptin-STAT3 signaling., PMID:40442088
Bile acids produced by gut microbiota activate TGR5 to promote colorectal liver metastasis progression by inducing MDSCs infiltration in liver., PMID:40367692
Crosstalk Between Bile Acids and Intestinal Epithelium: Multidimensional Roles of Farnesoid X Receptor and Takeda G Protein Receptor 5., PMID:40362481
Research Progress on the Mechanism of Bile Acids and Their Receptors in Depression., PMID:40362260
Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD-MASH Transition by Disrupting Carnitine Biosynthesis., PMID:40344326
Taurochenodeoxycholic acid activates autophagy and suppresses inflammatory responses in microglia of MPTP-induced Parkinson's disease mice via AMPK/mTOR, AKT/NFκB and Pink1/Parkin signaling pathways mediated by Takeda G protein-coupled receptor 5., PMID:40324640
Geniposide via enema alleviates colitis by modulating intestinal flora and bile acid metabolites, inhibiting S100A8/S100A9/NF-κB, and promoting TGR5 inhibition of NLRP3 inflammasome., PMID:40279965
Determinants of site-selectivity in human ileal bile acid-binding protein by NMR dynamic analysis of a functionally-impaired mutant., PMID:40268173
Exploring the Interconnections Between Mitochondrial Dysfunction and Polycystic Ovary Syndrome: A Comprehensive Integrated Analysis., PMID:40259200
Evidence for the involvement of secondary bile acids on peripheral and central regulation of feed intake in rainbow trout., PMID:40257242
The gut microbiota-bile acid-TGR5 axis orchestrates platelet activation and atherothrombosis., PMID:40217125
Role of bile acid-dependent Takeda G-coupled protein receptor 5 (TGR5) in regulating AMPK expression in human podocytes., PMID:40147352
Identification and Characterization of a Leoligin-Inspired Synthetic Lignan as a TGR5 Agonist., PMID:40146132
Salidroside attenuates NASH through regulating bile acid-FXR/TGR5 signaling pathway via targeting gut microbiota., PMID:40118401
Allo-lithocholic acid, a microbiome derived secondary bile acid, attenuates liver fibrosis., PMID:40118285
Total dietary fiber of tartary buckwheat alleviates T2DM through the IRS-1/PI3K/AKT pathway and gut microbiota-bile acids-TGR5/FXR axis in db/db mice., PMID:40101829
TGR5 Activation by Dietary Bioactives and Related Improvement in Mitochondrial Function for Alleviating Diabetes and Associated Complications., PMID:40045496
Decoding TGR5: A comprehensive review of its impact on cerebral diseases., PMID:39988005
Python-derived 16α-Hydroxylated Bile Acid, Pythocholic Acid is a ligand for TGR5, not farnesoid X receptors and vitamin D receptors., PMID:39923459
Post sleeve gastrectomy-enriched gut commensal Clostridia promotes secondary bile acid increase and weight loss., PMID:39915243
Lactopontin regulates gut microbiota and calcium absorption to promote bone growth in growing rats., PMID:39894097
Progesterone sulfates are enterohepatically recycled and stimulate G protein-coupled bile acid receptor 1-mediated gut hormone release., PMID:39888313
Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro., PMID:39881219
Metabolite-Sensing Receptors: Emerging Targets for Modulating Chronic Pain Pathways., PMID:39852178
Identification of crucial pathways and genes linked to endoplasmic reticulum stress in PCOS through combined bioinformatic analysis., PMID:39850756
Long-term effects of Nε-carboxymethyllysine intake on intestinal barrier permeability: Associations with gut microbiota and bile acids., PMID:39849698
Oleanolic acid inhibits appetite through the TGR5/cAMP signaling pathway., PMID:39842616
TGR5 attenuates DOCA-salt hypertension through regulating histone H3K4 methylation of ENaC in the kidney., PMID:39824478
Liver GPBAR1 Associates With Immune Dysfunction in Primary Sclerosing Cholangitis and Its Activation Attenuates Cholestasis in Abcb4-/- Mice., PMID:39804015
The discovery of a new nonbile acid modulator of Takeda G protein-coupled receptor 5: An integrated computational approach., PMID:39801251
Ramulus Mori (Sangzhi) alkaloids ameliorate high-fat diet induced obesity in rats by modulating gut microbiota and bile acid metabolism., PMID:39758340
Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders., PMID:39733841
Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation., PMID:39707318
Roux-en-Y gastric bypass alleviates kidney inflammation and improves kidney function in db/db mice by activating TLCA/TGR5 pathway., PMID:39681344
Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases., PMID:39667579
Microbial-derived bile acid reverses inflammation in IBD via GPBAR1 agonism and RORγt inverse agonism., PMID:39657506
Single-cell transcriptomics of human organoid-derived enteroendocrine cell populations from the small intestine., PMID:39639676
The potential mechanism of action of gut flora and bile acids through the TGR5/TRPV1 signaling pathway in diabetic peripheral neuropathic pain., PMID:39619328
TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis., PMID:39603503
Yi-Fei-San-Jie Chinese medicine formula reverses immune escape by regulating deoxycholic acid metabolism to inhibit TGR5/STAT3/PD-L1 axis in lung cancer., PMID:39515098
Therapeutic Effects of Zanthoxyli Pericarpium on Intestinal Inflammation and Network Pharmacological Mechanism Analysis in a Dextran Sodium Sulfate-Induced Colitis Mouse Model., PMID:39458516
Activation of TGR5 in the injured nerve site according to a prevention protocol mitigates partial sciatic nerve ligation-induced neuropathic pain by alleviating neuroinflammation., PMID:39450924
Molecular mechanisms underlying glucose-dependent insulinotropic polypeptide secretion in human duodenal organoids., PMID:39441374
Oral Administration of Taurodeoxycholate, A GPCR19 Agonist, Effectively Ameliorates Atopic Dermatitis in A Mouse Model., PMID:39428869
Cholic acid activation of GPBAR1 does not induce or exacerbate acute pancreatitis but promotes exocrine pancreatic secretion., PMID:39426134
UDCA ameliorates inflammation driven EMT by inducing TGR5 dependent SOCS1 expression in mouse macrophages., PMID:39414916
Bile Acids-Based Therapies for Primary Sclerosing Cholangitis: Current Landscape and Future Developments., PMID:39404413
Gut Bacteroides ovatus ameliorates renal fibrosis by promoting the production of HDCA through upregulation of Clostridium scindens., PMID:39392759
Integration of UPLC-MS/MS-based metabolomics and desorption electrospray ionization-mass spectrometry imaging reveals that Shouhui Tongbian Capsule alleviates slow transit constipation by regulating bile acid metabolism., PMID:39369590
For research use only. Not for human or drug use.
