Catalog No.
YHN52101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser281-His620
Predicted molecular weight
41.44 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IYD8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Fanconi anemia group M protein, Protein FACM, 3.6.4.13, ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog, FANCM, KIAA1596
Potent Cyclic Peptide Inhibitors Disrupt the FANCM-RMI Interaction., PMID:40479515
DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeres., PMID:40475582
Structural basis of Fanconi anemia pathway activation by FANCM., PMID:40447800
Comprehensive interrogation of synthetic lethality in the DNA damage response., PMID:40205037
Genetic dissection of MutL complexes in Arabidopsis meiosis., PMID:40105242
Chronic replication stress-mediated genomic instability disrupts placenta development in mice., PMID:40093167
Population-based study of recurrent DNA damage response gene variants in breast cancer cases., PMID:40009290
Locking the gates of immortality: targeting alternative lengthening of telomeres (ALT) pathways., PMID:39964637
Genetic buffering mechanisms in SNF2-family translocases., PMID:39890571
Q&A with Ying Wai Chan., PMID:39885657
RAB3GAP2 dysregulation in adult T-cell leukemia/lymphoma (ATLL) compared to acute lymphoblastic leukemia (ALL): a molecular perspective., PMID:39838474
The single-stranded DNA-binding factor SUB1/PC4 alleviates replication stress at telomeres and is a vulnerability of ALT cancer cells., PMID:39772744
Germline Variants in DNA Interstrand-Cross Link Repair Genes May Contribute to Increased Susceptibility for Serrated Polyposis Syndrome., PMID:39519399
Profound synthetic lethality between SMARCAL1 and FANCM., PMID:39510066
The kinase ATR controls meiotic crossover distribution at the genome scale in Arabidopsis., PMID:39471331
Somatic gene mutations involved in DNA damage response/Fanconi anemia signaling are tissue- and cell-type specific in human solid tumors., PMID:39421870
Novel insights into the mechanisms of seasonal cyclicity of testicles by proteomics and transcriptomics analyses in goose breeder lines., PMID:39190991
Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase., PMID:39189453
The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks., PMID:39152113
Lin28a forms an RNA-binding complex with Igf2bp3 to regulate m6A-modified stress response genes in stress granules of muscle stem cells., PMID:39021312
FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition., PMID:38985669
[Homozygous Variant of FANCM of the Fanconi Anemia Pathway Causes Premature Ovarian Insufficiency: Investigation of the Pathogenic Mechanism]., PMID:38948269
PCAF promotes R-loop resolution via histone acetylation., PMID:38936834
FANCM Gene Variants in a Male Diagnosed with Sertoli Cell-Only Syndrome and Diffuse Astrocytoma., PMID:38927643
Fluorescence polarization assay for screening FANCM-RMI inhibitors to target the alternative lengthening of telomeres., PMID:38886039
FANCM branchpoint translocase: Master of traverse, reverse and adverse DNA repair., PMID:38878565
Discovery of NSD2 non-histone substrates and design of a super-substrate., PMID:38851815
Crucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression., PMID:38847937
Clinical actionability of BRCA2 alterations in uterine leiomyosarcoma: a molecular tumor board case report and a cBioPortal comprehensive analysis., PMID:38716772
A minimal Fanconi Anemia complex in early diverging fungi., PMID:38688950
Diverse genetic causes of amenorrhea in an ethnically homogeneous cohort and an evolving approach to diagnosis., PMID:38521400
MutSβ protects common fragile sites by facilitating homology-directed repair at DNA double-strand breaks with secondary structures., PMID:38038265
Synthetically induced Arabidopsis thaliana autotetraploids provide insights into the analysis of meiotic mutants with altered crossover frequency., PMID:37921581
Helicases in R-loop Formation and Resolution., PMID:37778731
Angioimmunoblastic T-cell lymphoma: Novel recurrent mutations and prognostic biomarkers by cell-free DNA profiling., PMID:37646306
Germline Variants Incidentally Detected via Tumor-Only Genomic Profiling of Patients With Mesothelioma., PMID:37556141
Mannich Base PIP-199 Is a Chemically Unstable Pan-Assay Interference Compound., PMID:37555818
Prevalence and clinical implications of germline pathogenic variants in cancer predisposing genes in young patients across sarcoma subtypes., PMID:37536918
Germ line variants in patients with acute myeloid leukemia without a suspicion of hereditary hematologic malignancy syndrome., PMID:37450374
Spectrum and Frequency of Germline FANCM Protein-Truncating Variants in 44,803 European Female Breast Cancer Cases., PMID:37444426
Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis., PMID:37296437
Mapping the landscape of genetic dependencies in chordoma., PMID:37024492
Hyperextended telomeres promote formation of C-circle DNA in telomerase positive human cells., PMID:37003504
New pathogenic germline variants identified in mesothelioma., PMID:36944283
Association of FANCM Mutations with Familial and Early-Onset Breast Cancer Risk in a South American Population., PMID:36835452
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women., PMID:36707629
The FANCC-FANCE-FANCF complex is evolutionarily conserved and regulates meiotic recombination., PMID:36652992
Characterization of Serous Cell-Free DNA in Myelodysplastic Syndromes., PMID:36503307
MUS81 is required for atypical recombination intermediate resolution but not crossover designation in rice., PMID:36495065
Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal., PMID:36476850
For research use only. Not for human or drug use.
