Catalog No.
YHN48601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg45-Glu97
Predicted molecular weight
33.89 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96FE7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Phosphoinositide-3-kinase-interacting protein 1, PI3K-interacting protein 1, Kringle domain-containing protein HGFL, PIK3IP1, HGFL
Downregulation of PIK3IP1/TrIP on T cells is controlled by TCR signal strength, PKC, and metalloprotease-mediated cleavage., PMID:39454954
Exploring genetic and immune cell dynamics in systemic lupus erythematosus patients with Epstein-Barr virus infection via machine learning., PMID:39361430
Transcriptome analysis of human dental pulp cells cultured on a novel cell-adhesive fragment by RNA sequencing., PMID:38901533
PIK3IP1: structure, aberration, function, and regulation in diseases., PMID:38897445
Downregulation of PIK3IP1/TrIP on T cells is controlled by TCR signal strength, PKC and metalloprotease-mediated cleavage., PMID:38746242
CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1., PMID:38658954
Screening for immune-related biomarkers associated with myasthenia gravis and dilated cardiomyopathy based on bioinformatics analysis and machine learning., PMID:38571624
Downregulation of PIK3IP1 in retinal microglia promotes retinal pathological neovascularization via PI3K-AKT pathway activation., PMID:37550343
PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma., PMID:37267517
Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionality., PMID:37253991
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus., PMID:36864135
MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis., PMID:36701842
Upregulation of PIK3IP1 monitors the anti-cancer activity of PI3Kα inhibitors in gastric cancer cells., PMID:36521557
Targeting EZH2 Promotes Chemosensitivity of BCL-2 Inhibitor through Suppressing PI3K and c-KIT Signaling in Acute Myeloid Leukemia., PMID:36232694
Regulation of autoimmune disease progression by Pik3ip1 through metabolic reprogramming in T cells and therapeutic implications., PMID:36179018
Characterization of 22q12 Microdeletions Causing Position Effect in Rare NF2 Patients with Complex Phenotypes., PMID:36077416
Anti-Ischemic Effects of PIK3IP1 Are Mediated through Its Interactions with the ETA-PI3Kγ-AKT Axis., PMID:35883611
ARID1A-deficient bladder cancer is dependent on PI3K signaling and sensitive to EZH2 and PI3K inhibitors., PMID:35852858
The CpG Island-Binding Protein SAMD1 Contributes to an Unfavorable Gene Signature in HepG2 Hepatocellular Carcinoma Cells., PMID:35453756
Urine proteomics as a non-invasive approach to monitor exertional rhabdomyolysis during military training., PMID:35134564
Suppression of PI3K signaling is linked to autophagy activation and the spatiotemporal induction of the lens organelle free zone., PMID:35101390
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway., PMID:35000528
Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress., PMID:34197623
RiPerC Attenuates Cerebral Ischemia Injury through Regulation of miR-98/PIK3IP1/PI3K/AKT Signaling Pathway., PMID:33082912
Control of T lymphocyte fate decisions by PI3K signaling., PMID:33024547
PIK3IP1 Promotes Extrafollicular Class Switching in T-Dependent Immune Responses., PMID:32887751
MicroRNA-19a-3p regulates cell growth through modulation of the PIK3IP1-AKT pathway in hepatocellular carcinoma., PMID:32201518
A Ras-LSD1 axis activates PI3K signaling through PIK3IP1 suppression., PMID:31900384
Lipopolysaccharide and tumor necrosis factor-alpha alter gene expression of oocytes and cumulus cells during bovine in vitro maturation., PMID:31663199
Pik3ip1 Is a Negative Immune Regulator that Inhibits Antitumor T-Cell Immunity., PMID:31350312
GRP94 promotes muscle differentiation by inhibiting the PI3K/AKT/mTOR signaling pathway., PMID:31025379
FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synoviocytes., PMID:30679758
Identification of potential target genes associated with the reversion of androgen-dependent skeletal muscle atrophy., PMID:30639329
PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt., PMID:30429249
Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS., PMID:29592892
Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer., PMID:29590609
Expression of PIK3IP1 in the murine uterus during early pregnancy., PMID:29289536
Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality., PMID:29259156
Long non-coding RNA CCAT1/miR-148a axis promotes osteosarcoma proliferation and migration through regulating PIK3IP1., PMID:28549102
Cutting Edge: Foxp1 Controls Naive CD8+ T Cell Quiescence by Simultaneously Repressing Key Pathways in Cellular Metabolism and Cell Cycle Progression., PMID:27001958
A cardiac myocyte-restricted Lin28/let-7 regulatory axis promotes hypoxia-mediated apoptosis by inducing the AKT signaling suppressor PIK3IP1., PMID:26655604
ARID1A gene mutation in ovarian and endometrial cancers (Review)., PMID:26572704
Pik3ip1 modulates cardiac hypertrophy by inhibiting PI3K pathway., PMID:25826393
Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers., PMID:25686104
Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma., PMID:25082755
Innate cytokine profiling of bovine alveolar macrophages reveals commonalities and divergence in the response to Mycobacterium bovis and Mycobacterium tuberculosis infection., PMID:24882682
Transcriptional activation of PIK3R1 by PPARγ in adipocytes., PMID:24859974
Inactivating CUX1 mutations promote tumorigenesis., PMID:24316979
Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1., PMID:23676220
The genetic landscape of mutations in Burkitt lymphoma., PMID:23143597
For research use only. Not for human or drug use.
