Catalog No.
YHN47501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys1792-Asp2078
Predicted molecular weight
34.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96BY7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Autophagy-related protein 2 homolog B, ATG2B, C14orf103
SIRT1-based therapy targets a gene program involved in mitochondrial turnover in a model of retinal neurodegeneration., PMID:40253451
ATG2A acts as a tether to regulate autophagosome-lysosome fusion in neural cells., PMID:40083067
Inhibition of ACSS2 triggers glycolysis inhibition and nuclear translocation to activate SIRT1/ATG5/ATG2B deacetylation axis, promoting autophagy and reducing malignancy and chemoresistance in ovarian cancer., PMID:39362518
Human gastric cancer progression and stabilization of ATG2B through RNF5 binding facilitated by autophagy-associated CircDHX8., PMID:38866787
Bioinformatics proved the existence of potential hub genes activating autophagy to participate in cartilage degeneration in osteonecrosis of the femoral head., PMID:38758521
[Knockdown mitochondrial transcription factor A (TFAM) inhibits autophagy, proliferation, invasion and migration in human cervical cancer and osteosarcoma cells]., PMID:38710515
Autozygome-guided exome-first study in a consanguineous cohort with early-onset retinal disease uncovers an isolated RIMS2 phenotype and a retina-enriched RIMS2 isoform., PMID:38468396
Ame-miR-980-3p participates in autophagy-mediated midgut remodelling in Apis mellifera via targeting Atg2B., PMID:37658706
Identification and cross-validation of autophagy-related genes in cardioembolic stroke., PMID:37305740
ATG2B upregulated in LPS-stimulated BMSCs-derived exosomes attenuates septic liver injury by inhibiting macrophage STING signaling., PMID:36857936
Identification of an Autophagy-Related Signature for Prognosis and Immunotherapy Response Prediction in Ovarian Cancer., PMID:36830707
Modulation of cellular autophagy by genotype 1 hepatitis E virus ORF3 protein., PMID:36809248
Ginsenoside Rg1 attenuates the NASH phenotype by regulating the miR-375-3p/ATG2B/PTEN-AKT axis to mediate autophagy and pyroptosis., PMID:36759837
LncRNA MEG3 promotes the sensitivity of bortezomib by inhibiting autophagy in multiple myeloma., PMID:36270092
The prognostic value of autophagy related genes with potential protective function in Ewing sarcoma., PMID:35902797
Polymorphisms in autophagy genes are genetic susceptibility factors in glioblastoma development., PMID:35123435
Autophagy inhibits cancer stemness in triple-negative breast cancer via miR-181a-mediated regulation of ATG5 and/or ATG2B., PMID:35029026
Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size., PMID:34748402
Downregulation of LINC01296 suppresses non-small-cell lung cancer via targeting miR-143-3p/ATG2B., PMID:34695177
Identification of autophagic target RAB13 with small-molecule inhibitor in low-grade glioma via integrated multi-omics approaches coupled with virtual screening of traditional Chinese medicine databases., PMID:34632655
Suppression of autophagy promotes fibroblast activation in p53-deficient colorectal cancer cells., PMID:34593902
Crocin exerts anti-proliferative and apoptotic effects on cutaneous squamous cell carcinoma via miR-320a/ATG2B., PMID:34320900
ATG4s: above and beyond the Atg8-family protein lipidation system., PMID:34308753
Germline ATG2B/GSKIP-containing 14q32 duplication predisposes to early clonal hematopoiesis leading to myeloid neoplasms., PMID:34172895
Potential roles for microRNAs in facilitating physiological adaptation to low-temperature stress in Penaeus vannamei., PMID:34061996
Minimized combinatorial CRISPR screens identify genetic interactions in autophagy., PMID:33956155
LncRNA-HOTAIR activates autophagy and promotes the imatinib resistance of gastrointestinal stromal tumor cells through a mechanism involving the miR-130a/ATG2B pathway., PMID:33824300
miR‑143‑3p inhibits endometriotic stromal cell proliferation and invasion by inactivating autophagy in endometriosis., PMID:33760149
MicroRNA-130a inhibits proliferation of vascular smooth muscle cells by suppressing autophagy via ATG2B., PMID:33611856
ATG2B/GSKIP in de novo acute myeloid leukemia (AML): high prevalence of germline predisposition in French West Indies., PMID:33554699
Yunvjian-Medicated Serum Protects INS-1 Cells against Glucolipotoxicity-Induced Apoptosis through Autophagic Flux Modulation., PMID:33414841
Polymorphism in autophagy gene ATG2B is not associated with bladder cancer recurrence after intravesical Bacillus Calmette-Guerin (BCG) immunotherapy in Asian patients., PMID:33250346
Lipids and membrane-associated proteins in autophagy., PMID:33151516
MiR-143-3p targets ATG2B to inhibit autophagy and promote endothelial progenitor cells tube formation in deep vein thrombosis., PMID:33130456
MicroRNA-143 sensitizes acute myeloid leukemia cells to cytarabine via targeting ATG7- and ATG2B-dependent autophagy., PMID:33077697
miR-375 targeting autophagy-related 2B (ATG2B) suppresses autophagy and tumorigenesis in cisplatin-resistant osteosarcoma cells., PMID:32726125
miR-1278 sensitizes nasopharyngeal carcinoma cells to cisplatin and suppresses autophagy via targeting ATG2B., PMID:32407879
MicroRNA-375 exacerbates knee osteoarthritis through repressing chondrocyte autophagy by targeting ATG2B., PMID:32335541
A conserved ATG2-GABARAP family interaction is critical for phagophore formation., PMID:32009292
RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations., PMID:31874152
Human ATG2B possesses a lipid transfer activity which is accelerated by negatively charged lipids and WIPI4., PMID:31721365
ATG2 regulation of phagophore expansion at mitochondria-associated ER membranes., PMID:31512567
ATG2 transports lipids to promote autophagosome biogenesis., PMID:30952800
Regulation of hepatic autophagy by stress-sensing transcription factor CREBH., PMID:30912978
TRAPPC11 functions in autophagy by recruiting ATG2B-WIPI4/WDR45 to preautophagosomal membranes., PMID:30843302
DIABLO/SMAC mimetics selectively kill HIV-1-infected resting memory CD4+ T cells: a potential role in a cure strategy for HIV-1 infection., PMID:30653393
VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites., PMID:30093493
Germline duplication of ATG2B and GSKIP genes is not required for the familial myeloid malignancy syndrome associated with the duplication of chromosome 14q32., PMID:30087419
MicroRNA-143 Targets ATG2B to Inhibit Autophagy and Increase Inflammatory Responses in Crohn's Disease., PMID:29562274
Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy., PMID:29454863
For research use only. Not for human or drug use.
