Recombinant Human LRRC4 Protein, N-His

Catalog No.

YHN18701

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Ala39-Thr443

Predicted molecular weight

47.82 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

Q9HBW1

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Leucine-rich repeat-containing protein 4, Brain tumor-associated protein BAG, Nasopharyngeal carcinoma-associated gene 14 protein, Netrin-G2 ligand, NGL-2, LRRC4, BAG, NAG14, UNQ554/PRO1111

LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells., PMID:40317712

Effects of electroacupuncture on repairing neurological damage following ischemic stroke based on miR-381-mediated SDF-1/CXCR4 signaling pathway., PMID:38373763

Genome-wide CRISPRi Screen in Human iNeurons to Identify Novel Focal Cortical Dysplasia Genes., PMID:38168415

A Massively Parallel Screen of 5'UTR Mutations Identifies Variants Impacting Translation and Protein Production in Neurodevelopmental Disorder Genes., PMID:37961498

Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea., PMID:37402769

Membrane-bound transcription factor LRRC4 inhibits glioblastoma cell motility., PMID:37385320

Leucine-rich repeats containing 4 protein (LRRC4) in memory, psychoneurosis, and glioblastoma., PMID:36780420

LRRC4 functions as a neuron-protective role in experimental autoimmune encephalomyelitis., PMID:33932995

Identification of circRNA-lncRNA-miRNA-mRNA Competitive Endogenous RNA Network as Novel Prognostic Markers for Acute Myeloid Leukemia., PMID:32751923

Dexmedetomidine protects PC12 cells from ropivacaine injury through miR-381/LRRC4 /SDF-1/CXCR4 signaling pathway., PMID:32467829

Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide., PMID:32372061

Homozygous frameshift variant in NTNG2, encoding a synaptic cell adhesion molecule, in individuals with developmental delay, hypotonia, and autistic features., PMID:31372774

Identification of Coiled-Coil Domain-Containing Protein 180 and Leucine-Rich Repeat-Containing Protein 4 as Potential Immunohistochemical Markers for Liposarcoma Based on Proteomic Analysis Using Formalin-Fixed, Paraffin-Embedded Tissue., PMID:30790560

Locomotor Training Increases Synaptic Structure With High NGL-2 Expression After Spinal Cord Hemisection., PMID:30782076

NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation., PMID:29949768

MicroRNA-381 Favors Repair of Nerve Injury Through Regulation of the SDF-1/CXCR4 Signaling Pathway via LRRC4 in Acute Cerebral Ischemia after Cerebral Lymphatic Blockage., PMID:29669322

Synapse maintenance and restoration in the retina by NGL2., PMID:29553369

Novel Therapy for Glioblastoma Multiforme by Restoring LRRC4 in Tumor Cells: LRRC4 Inhibits Tumor-Infitrating Regulatory T Cells by Cytokine and Programmed Cell Death 1-Containing Exosomes., PMID:29312296

Mapping of leptin and its syntenic genes to chicken chromosome 1p., PMID:28793857

RHCG and TCAF1 promoter hypermethylation predicts biochemical recurrence in prostate cancer patients treated by radical prostatectomy., PMID:28052017

The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells., PMID:27884160

Low expression of miR-381 is a favorite prognosis factor and enhances the chemosensitivity of osteosarcoma., PMID:27612424

Expression and clinical significance of LRRC4 in benign and malignant nasopharyngeal diseases., PMID:26662436

Gene-Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-Based Microarray Analysis., PMID:26136121

NGL-2 Is a New Partner of PAR Complex in Axon Differentiation., PMID:25948265

Function and mechanism of tumor suppressor gene LRRC4/NGL-2., PMID:25526788

Netrin-G/NGL complexes encode functional synaptic diversification., PMID:25411505

LRRC4 haplotypes are associated with pituitary adenoma in a Chinese population., PMID:24563334

Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4., PMID:24404152

NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons., PMID:23177961

LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway., PMID:22834685

[Transcriptomic regulation and molecular mechanism of polygenic tumor at different stages]., PMID:21873780

LRRC4 inhibits the proliferation of human glioma cells by modulating the expression of STMN1 and microtubule polymerization., PMID:21809374

Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth., PMID:21435336

The NGL family of leucine-rich repeat-containing synaptic adhesion molecules., PMID:19467332

Promoter hypermethylation-mediated inactivation of LRRC4 in gliomas., PMID:18976507

[Inhibitory effect of LRRC4 on the mobility and invasion of glioblastomas through the SDF-1alpha/CXCR4 axis]., PMID:18007062

Leucine-rich repeat C4 protein is involved in nervous tissue development and neurite outgrowth, and induction of glioma cell differentiation., PMID:17928921

[Preparation of anti-LRRC4 polyclonal antibody and its application in constructing expression profile of human gliomas with different pathological grades]., PMID:17611308

LRRC4 inhibits human glioblastoma cells proliferation, invasion, and proMMP-2 activation by reducing SDF-1 alpha/CXCR4-mediated ERK1/2 and Akt signaling pathways., PMID:17549698

LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses., PMID:17541939

[Expression absence of LRRC4 gene in glioblastoma cell lines]., PMID:17478928

[Blockage of U251 cells in G0/G1 through MAPK signaling pathway by LRRC4]., PMID:17478927

LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression., PMID:16941076

LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway., PMID:16723503

Profiling of differentially expressed genes in LRRC4 overexpressed glioblastoma cells by cDNA array., PMID:16215635

[Function of a novel brain-specific gene LRRC4]., PMID:16188120

Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system., PMID:16077900

Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily., PMID:15967442

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Recombinant Human LRRC4 Protein, N-His.pdf