Catalog No.
YHK29001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln173
Predicted molecular weight
21.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q93096
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PRL-1, PTP(CAAXI), PTPCAAX1, PTP4A1, Protein tyrosine phosphatase type IVA 1, PRL1, Protein-tyrosine phosphatase of regenerating liver 1, Protein-tyrosine phosphatase 4a1
Structure of the phosphocysteine intermediate of the phosphatase of regenerating liver PTP4A1., PMID:40398601
Aldose reductase -mediated HUR ubiquitination enhances exosome release and hepatic fibrosis via ROS/PI3K/AKT pathway., PMID:40334999
Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer., PMID:39995872
Dephosphorylation-related signature predicts the prognosis of papillary renal cell carcinoma., PMID:39697703
PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity., PMID:38948056
WTAP promotes proliferation of esophageal squamous cell carcinoma via m6A-dependent epigenetic promoting of PTP4A1., PMID:38746998
Targeting PRL phosphatases in hematological malignancies., PMID:38653737
Preparation of Oxidized and Reduced PTP4A1 for Structural and Functional Studies., PMID:38147218
Expression of PTP4A1 in circulating tumor cells and its efficacy evaluation in patients with early- and intermediate-stage esophageal cancer., PMID:38134119
PTP4A1 promotes oral squamous cell carcinoma (OSCC) metastasis through altered mitochondrial metabolic reprogramming., PMID:37773151
Single-cell sequencing analysis of peripheral blood in patients with moyamoya disease., PMID:37400835
PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics., PMID:36972446
Increased PRL-1 in BM-derived MSCs triggers anaerobic metabolism via mitochondria in a cholestatic rat model., PMID:36865088
Hepatic PTP4A1 ameliorates high-fat diet-induced hepatosteatosis and hyperglycemia by the activation of the CREBH/FGF21 axis., PMID:36793871
Circular RNA circ_0000212 accelerates cervical cancer progression by acting as a miR-625-5p sponge to upregulate PTP4A1., PMID:36729102
Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation., PMID:36534975
Evaluation of autoantibody signatures in pituitary adenoma patients using human proteome arrays., PMID:35939377
Inhibitory Effect of miR-339-5p on Glioma through PTP4A1/HMGB1 Pathway., PMID:35872698
Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET., PMID:35676290
Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex., PMID:35451370
Increased phosphatase regenerating liver-1 trigger vascular remodeling in injured ovary via platelet-derived growth factor signaling pathway., PMID:35255961
GINS2 regulates the proliferation and apoptosis of colon cancer cells through PTP4A1., PMID:35137928
The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice., PMID:35077201
ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12., PMID:35020952
Activation of the EGFR-PI3K-CaM pathway by PRL-1-overexpressing placenta-derived mesenchymal stem cells ameliorates liver cirrhosis via ER stress-dependent calcium., PMID:34689832
Proteomic profile of mesothelial exosomes isolated from peritoneal dialysis effluent of children with focal segmental glomerulosclerosis., PMID:34675284
Long non-coding RNA USP30-AS1 aggravates the malignant progression of cervical cancer by sequestering microRNA-299-3p and thereby overexpressing PTP4A1., PMID:33986866
LncRNA NEAT1 promotes cell proliferation, migration, and invasion via the miR-186-5p/PTP4A1 axis in cholangiocarcinoma., PMID:33502823
Circular RNA circNRIP1 promotes migration and invasion in cervical cancer by sponging miR-629-3p and regulating the PTP4A1/ERK1/2 pathway., PMID:32457332
Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain., PMID:31834974
Dynamic Regulation of miRNA Expression by Functionally Enhanced Placental Mesenchymal Stem Cells PromotesHepatic Regeneration in a Rat Model with Bile Duct Ligation., PMID:31653075
Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors., PMID:31307888
Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism., PMID:30718434
Exploring the cause of the inhibitor 4AX attaching to binding site disrupting protein tyrosine phosphatase 4A1 trimerization by molecular dynamic simulation., PMID:30661451
Phosphatase of Regenerating Liver-1 (PRL-1) Regulates Actin Dynamics During Immunological Synapse Assembly and T Cell Effector Function., PMID:30515156
miR-339-5p Increases Radiosensitivity of Lung Cancer Cells by Targeting Phosphatases of Regenerating Liver-1 (PRL-1)., PMID:30462625
Vasoinhibin comprises a three-helix bundle and its antiangiogenic domain is located within the first 79 residues., PMID:30459448
lncRNA GCAWKR Promotes Gastric Cancer Development by Scaffolding the Chromatin Modification Factors WDR5 and KAT2A., PMID:30274785
Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers., PMID:30252041
Physiological and oncogenic roles of the PRL phosphatases., PMID:29770564
Phosphatase of regenerating liver maintains cellular magnesium homeostasis., PMID:29487165
MicroRNA-1271 functions as a metastasis and epithelial-mesenchymal transition inhibitor in human HCC by targeting the PTP4A1/c-Src axis., PMID:29345291
Increased expression of GATA zinc finger domain containing 1 through gene amplification promotes liver cancer by directly inducing phosphatase of regenerating liver 3., PMID:29266303
PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis., PMID:29057934
Characterization of the Protein Tyrosine Phosphatase LmPRL-1 Secreted by Leishmania major via the Exosome Pathway., PMID:28507071
Overexpression of PTP4A3 in ETV6-RUNX1 acute lymphoblastic leukemia., PMID:28063378
Analyses of differentially expressed genes after exposure to acute stress, acute ethanol, or a combination of both in mice., PMID:28027852
Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2., PMID:27899452
Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis., PMID:27856537
Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway., PMID:27655691
For research use only. Not for human or drug use.
