Catalog No.
YHH14801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr264-Lys366
Predicted molecular weight
13.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15633
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RISC-loading complex subunit TARBP2, TAR RNA-binding protein 2, Trans-activation-responsive RNA-binding protein, TARBP2, TRBP
Trbp inhibits cardiac fibrosis through TGF-β pathway-mediated cross-talk between cardiomyocytes and fibroblasts., PMID:40067137
Single-molecule m6A detection empowered by endogenous labeling unveils complexities across RNA isoforms., PMID:39922195
Ythdf2 facilitates precursor miR-378/miR-378-5p maturation to support myogenic differentiation., PMID:39503763
AGO2 protein: a key enzyme in the miRNA pathway as a novel biomarker in adrenocortical carcinoma., PMID:39404265
A molecular mechanism underlies grass carp (Ctenopharyngodon idella) TARBP2 regulating PKR-mediated cell apoptosis., PMID:39278379
A novel TGFbeta/TGILR axis mediates crosstalk between cancer-associated fibroblasts and tumor cells to drive gastric cancer progression., PMID:38806480
Fever-range whole body hyperthermia leads to changes in immune-related genes and miRNA machinery in Wistar rats., PMID:37279921
The Role of Nucleases Cleaving TLR3, TLR7/8 and TLR9 Ligands, Dicer RNase and miRNA/piRNA Proteins in Functional Adaptation to the Immune Escape and Xenophagy of Prostate Cancer Tissue., PMID:36613950
Structural and functional basis of mammalian microRNA biogenesis by Dicer., PMID:36332606
LINC01526 Promotes Proliferation and Metastasis of Gastric Cancer by Interacting with TARBP2 to Induce GNG7 mRNA Decay., PMID:36230863
TARBP2-stablized SNHG7 regulates blood-brain barrier permeability by acting as a competing endogenous RNA to miR-17-5p/NFATC3 in Aβ-microenvironment., PMID:35562351
Grass carp (Ctenopharyngodon idella) Trans-Activation-Responsive RNA-binding protein 2 (TARBP2) inhibits apoptosis by decreasing PKR phosphorylation., PMID:35452690
TARBP2 Suppresses Ubiquitin-Proteasomal Degradation of HIF-1α in Breast Cancer., PMID:35008634
Loss of TARBP2 Drives the Progression of Hepatocellular Carcinoma via miR-145-SERPINE1 Axis., PMID:34249676
Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation., PMID:34174402
TARBP2 promotes tumor angiogenesis and metastasis by destabilizing antiangiogenic factor mRNAs., PMID:33484209
Alteration of miRNA Biogenesis Regulating Proteins in the Human Microglial Cell Line HMC-3 After Ischemic Stress., PMID:33210205
Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development., PMID:32478074
Hypoxia-induced let-7f-5p/TARBP2 feedback loop regulates osteosarcoma cell proliferation and invasion by inhibiting the Wnt signaling pathway., PMID:32305960
Actinidia Chinensis Planch Root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting the DLX2/TARBP2/JNK/AKT pathway., PMID:31891797
MicroRNA Biogenesis Pathway Genes Are Deregulated in Colorectal Cancer., PMID:31510013
Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay., PMID:31300274
Cloning, expression, and characterization of the zebrafish Dicer and Drosha enzymes., PMID:31029426
TARBP2 inhibits IRF7 activation by suppressing TRAF6-mediated K63-linked ubiquitination of IRF7., PMID:30927622
Main constraints for RNAi induced by expressed long dsRNA in mouse cells., PMID:30808654
TARBP2-Enhanced Resistance during Tamoxifen Treatment in Breast Cancer., PMID:30759864
TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma., PMID:30657254
TARBP2 negatively regulates IFN-β production and innate antiviral response by targeting MAVS., PMID:30390472
Association of variants of miRNA processing genes with cervical precancerous lesion risk in a southern Chinese population., PMID:29853562
Functional Redundancy of DICER Cofactors TARBP2 and PRKRA During Murine Embryogenesis Does Not Involve miRNA Biogenesis., PMID:29467169
Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival., PMID:29348664
SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis., PMID:29020972
MicroRNA expression profile in RAW264·7 macrophage cells exposed to Echinococcus multilocularis metacestodes., PMID:28942753
Regulating the Regulators in Attention-Deficit/Hyperactivity Disorder: A Genetic Association Study of microRNA Biogenesis Pathways., PMID:28557556
RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma., PMID:28369725
TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway., PMID:28174252
Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer., PMID:27980417
shRNA‑mediated silencing of TARBP2 inhibits NCI‑H1299 non‑small cell lung cancer cell invasion and migration via the JNK/STAT3/AKT pathway., PMID:27599909
Genetic variants in RNA-induced silencing complex genes and prostate cancer., PMID:27498138
The miRNA biogenesis in marine bivalves., PMID:26989613
A designed recombinant fusion protein for targeted delivery of siRNA to the mouse brain., PMID:26948382
SNP Variation in MicroRNA Biogenesis Pathway Genes as a New Innovation Strategy for Alzheimer Disease Diagnostics: A Study of 10 Candidate Genes in an Understudied Population From the Eastern Mediterranean., PMID:26796812
Gene-based pleiotropy across migraine with aura and migraine without aura patient groups., PMID:26660531
SUMOylation of TARBP2 regulates miRNA/siRNA efficiency., PMID:26582366
Expression of microRNAs and isomiRs in the porcine endometrium: implications for gene regulation at the maternal-conceptus interface., PMID:26546342
Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered KrasG12D;Pdx1-Cre mouse (KC) model., PMID:26516699
The role of TARBP2 in the development and progression of cancers., PMID:26486325
Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma., PMID:26087193
Trbp regulates heart function through microRNA-mediated Sox6 repression., PMID:26029872
Microsatellite instability: an update., PMID:25701956
For research use only. Not for human or drug use.
