Catalog No.
YHG08301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met106-Ala295
Predicted molecular weight
23.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q06265
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Exosome complex component RRP45, Autoantigen PM/Scl 1, Exosome component 9, P75 polymyositis-scleroderma overlap syndrome-associated autoantigen, Polymyositis/scleroderma autoantigen 1, Polymyositis/scleroderma autoantigen 75 kDa, PM/Scl-75, EXOSC9, PMSCL1
Mendelian randomization provides a multi-omics perspective on the regulation of genes involved in ribosome biogenesis in relation to cardiac structure and function., PMID:40045424
Disrupted maxillofacial, cardiovascular, and nervous development in washc5 knockout Zebrafish: Insights into 3C syndrome., PMID:39988189
Humanized Saccharomyces cerevisiae provides a facile and effective tool to identify damaging human variants that cause exosomopathies., PMID:39982806
Exosc9 Initiates SUMO-Dependent lncRNA TERRA Degradation to Impact Telomeric Integrity in Endocrine Therapy Insensitive Hormone Receptor-Positive Breast Cancer., PMID:37887339
Pontocerebellar hypoplasia associated with p.Arg183Trp homozygous variant in EXOSC1 gene: A case report., PMID:37024942
Linear Diagnostic Procedure Elicited by Clinical Genetics and Validated by mRNA Analysis in Neuronal Ceroid Lipofuscinosis 7 Associated with a Novel Non-Canonical Splice Site Variant in MFSD8., PMID:36833170
Complex Changes in the Efficiency of the Expression of Many Genes in Monogenic Diseases, Mucopolysaccharidoses, May Arise from Significant Disturbances in the Levels of Factors Involved in the Gene Expression Regulation Processes., PMID:35456399
Role of FRG1 in predicting the overall survivability in cancers using multivariate based optimal model., PMID:34795329
Diagnosis of myositis-associated interstitial lung disease: Utility of the myositis autoantibody line immunoassay., PMID:34454312
SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease., PMID:34263556
Risk of sudden cardiac death in EXOSC5-related disease., PMID:34089229
Bi-allelic missense variant, p.Ser35Leu in EXOSC1 is associated with pontocerebellar hypoplasia., PMID:33463720
Novel EXOSC9 variants cause pontocerebellar hypoplasia type 1D with spinal motor neuronopathy and cerebellar atrophy., PMID:33040083
RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels., PMID:32527837
EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells., PMID:32518284
Performance evaluation of a line blot assay system for detection of anti-PM-Scl antibody in Japanese patients with systemic sclerosis., PMID:31245910
An Anti-PM/Scl-75 Antibody-positive Japanese Woman Who Developed Inflammatory Myopathy., PMID:31178484
Expanded PCH1D phenotype linked to EXOSC9 mutation., PMID:30690203
Enhancers in the Peril lincRNA locus regulate distant but not local genes., PMID:30537984
Senataxin, A Novel Helicase at the Interface of RNA Transcriptome Regulation and Neurobiology: From Normal Function to Pathological Roles in Motor Neuron Disease and Cerebellar Degeneration., PMID:29916023
Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy., PMID:29727687
Ptbp1 and Exosc9 knockdowns trigger skin stability defects through different pathways., PMID:26546114
Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis., PMID:26246178
Good outcome of interstitial lung disease in patients with scleroderma associated to anti-PM/Scl antibody., PMID:25110305
Identification of UACA, EXOSC9, and ΤΜX2 in bovine periosteal cells by mass spectrometry and immunohistochemistry., PMID:24696107
A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage., PMID:24105744
A new strategy for gene targeting and functional proteomics using the DT40 cell line., PMID:23892402
Progenitor function in self-renewing human epidermis is maintained by the exosome., PMID:22770246
Identification of differentially expressed transcripts in bovine rumen and abomasum using a differential display method., PMID:17235024
For research use only. Not for human or drug use.
