Catalog No.
YHE79401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln25-Arg539
Predicted molecular weight
57.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P50991
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CCTD, T-complex protein 1 subunit delta, TCP-1-delta, Stimulator of TAR RNA-binding, CCT4, CCT-delta, SRB
The conformational landscape of TRiC ring-opening and its underlying stepwise mechanism revealed by cryo-EM., PMID:40070846
Comparative proteomic and transcriptomic analysis of testicular tissue of yaks with or without cryptorchidism., PMID:40068345
Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infection., PMID:39850902
Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs., PMID:38367684
LINC01234 promoted malignant behaviors of breast cancer cells via hsa-miR-30c-2-3p/CCT4/mTOR signaling pathway., PMID:38216268
A hierarchical assembly pathway directs the unique subunit arrangement of TRiC/CCT., PMID:37625406
Prognostic Role of Unfolded Protein Response-Related Genes in Hepatocellular Carcinoma., PMID:37587817
Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling., PMID:37143143
Role of CCT4/ErbB signaling in nephroblastoma: Implications for a biomarker of Wilms tumor., PMID:37058032
A genome-wide CRISPR screen identifies the CCT chaperonin as a critical regulator of vesicle trafficking., PMID:36607310
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas., PMID:36102200
Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis., PMID:35646538
Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway., PMID:35239512
Nutrigenomic Studies on the Ameliorative Effect of Enzyme-Digested Phycocyanin in Alzheimer's Disease Model Mice., PMID:34959983
CCT4 suppression inhibits tumor growth in hepatocellular carcinoma by interacting with Cdc20., PMID:34732665
T-complex protein 1 subunit zeta-2 (CCT6B) deficiency induces murine teratospermia., PMID:34141486
Prognostic Power of a Chaperonin Containing TCP-1 Subunit Genes Panel for Hepatocellular Carcinoma., PMID:33897772
Systematic Characterization of Expression Profiles and Prognostic Values of the Eight Subunits of the Chaperonin TRiC in Breast Cancer., PMID:33815471
CCTs as new biomarkers for the prognosis of head and neck squamous cancer., PMID:33313411
An Efficient Screen for Cell-Intrinsic Factors Identifies the Chaperonin CCT and Multiple Conserved Mechanisms as Mediating Dendrite Morphogenesis., PMID:33100975
State-dependent sequential allostery exhibited by chaperonin TRiC/CCT revealed by network analysis of Cryo-EM maps., PMID:32866476
Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis., PMID:31964905
The TCP1 ring complex is associated with malignancy and poor prognosis in hepatocellular carcinoma., PMID:31934176
Identifying functions and prognostic biomarkers of network motifs marked by diverse chromatin states in human cell lines., PMID:31537905
An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity., PMID:31492816
Co-expression of CCT subunits hints at TRiC assembly., PMID:31410727
TRiC/CCT chaperonins are essential for organ growth by interacting with insulin/TOR signaling in Drosophila., PMID:30792539
HNRNP Q suppresses polyglutamine huntingtin aggregation by post-transcriptional regulation of vaccinia-related kinase 2., PMID:30488434
The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B., PMID:30181275
Genetic expansion of chaperonin-containing TCP-1 (CCT/TRiC) complex subunits yields testis-specific isoforms required for spermatogenesis in planarian flatworms., PMID:29095551
Reprogramming cell fate with a genome-scale library of artificial transcription factors., PMID:27930301
CCT complex restricts neuropathogenic protein aggregation via autophagy., PMID:27929117
Transient Kinetic Analysis of ATP Hydrolysis by the CCT/TRiC Chaperonin., PMID:27686496
Quantitative proteomics reveals the novel co-expression signatures in early brain development for prognosis of glioblastoma multiforme., PMID:26895104
Over-Expression Analysis of All Eight Subunits of the Molecular Chaperone CCT in Mammalian Cells Reveals a Novel Function for CCTdelta., PMID:26101841
Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy., PMID:25124038
Vaccinia-related kinase 2 mediates accumulation of polyglutamine aggregates via negative regulation of the chaperonin TRiC., PMID:24298020
Serum antibody response to group II chaperonin from Methanobrevibacter oralis and human chaperonin CCT., PMID:23620386
Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers., PMID:23612981
Molecular targets for diabetes mellitus-associated erectile dysfunction., PMID:20007950
Translation termination and protein folding pathway genes are not correlated in gastric cancer., PMID:19284299
Overexpressed ribosomal proteins suppress defective chaperonins in Saccharomyces cerevisiae., PMID:18680526
ATP-induced allostery in the eukaryotic chaperonin CCT is abolished by the mutation G345D in CCT4 that renders yeast temperature-sensitive for growth., PMID:18272176
Mutation in the epsilon subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia., PMID:16399879
Cutaneous and sympathetic denervation in neonatal rats with a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 gene., PMID:15193290
Hereditary sensory neuropathy is caused by a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct4 ) gene., PMID:12874111
The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex., PMID:12697815
Temporal gene expression profile of human precursor B leukemia cells induced by adhesion receptor: identification of pathways regulating B-cell survival., PMID:12393420
Complete cDNA and deduced amino acid sequence of the chaperonin containing T-complex polypeptide 1 (CCT) delta subunit from Aedes triseriatus mosquitoes., PMID:11762197
Mutational screen identifies critical amino acid residues of beta-actin mediating interaction between its folding intermediates and eukaryotic cytosolic chaperonin CCT., PMID:11580268
For research use only. Not for human or drug use.
