Catalog No.
YHE15701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp138-Leu376
Predicted molecular weight
30.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35790
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Choline kinase alpha, CK, 2.7.1.32, CHETK-alpha, Ethanolamine kinase, EK, 2.7.1.82, CHKA, CHK, CKI
Core Molecular Clock Factors Regulate Osteosarcoma Stem Cell Survival and Behavior via CSC/EMT Pathways and Lipid Droplet Biogenesis., PMID:40214471
Chloroquine Suppresses Colorectal Cancer Progression via Targeting CHKA and PFKM to inhibit the PI3K/AKT Pathway and the Warburg Effect., PMID:39990656
Choline kinase alpha regulates autophagy-associated exosome release to promote glioma cell progression., PMID:39778250
Phenomics-Based Discovery of Novel Orthosteric Choline Kinase Inhibitors., PMID:39740997
Disulfiram/Cu targeting FOXO6 modulates sensitivity of hepatocellular carcinoma to lenvatinib via disrupt choline metabolic., PMID:39694126
Phosphocholine inhibits proliferation and reduces stemness of endometrial cancer cells by downregulating mTOR-c-Myc signaling., PMID:39680126
Choline kinases: Enzymatic activity, involvement in cancer and other diseases, inhibitors., PMID:39660774
Is choline kinase alpha a drug target for obesity?, PMID:39568820
Targeted inhibition of CHKα and mTOR in models of pancreatic ductal adenocarcinoma: A novel regimen for metastasis., PMID:39343354
Elevated choline drives KLF5-dominated transcriptional reprogramming to facilitate liver cancer progression., PMID:39251845
Advanced glycation end products promote the progression of endometrial cancer via activating the RAGE/CHKA/PI3K/AKT signaling pathway., PMID:39180262
Directing novel ChoKα1 inhibitors using MamC-mediated biomimetic magnetic nanoparticles: a way to improve specificity and efficiency., PMID:39116523
Lipid Nanoparticle-Mediated Delivery of CRISPR-Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism., PMID:38894572
PLA2G4A and ACHE modulate lipid profiles via glycerophospholipid metabolism in platinum-resistant gastric cancer., PMID:38454407
Mfsd7b facilitates choline transport and missense mutations affect choline transport function., PMID:38055060
N-carbamylglutamate supplementation induces functional egg production in layers by modulating liver transcriptome profiles., PMID:38035861
Correlation between choline kinase alpha expression and 11C-choline accumulation in breast cancer using positron emission tomography/computed tomography: a retrospective study., PMID:37848481
Intermediate metabolites and molecular correlates of one‑carbon and nutrient metabolism differ in tissues from Holstein fetuses., PMID:37678126
Comparative transcriptome analysis reveals mechanisms of restriction feeding on lipid metabolism in ducks., PMID:37586191
Dandelion extract inhibits triple-negative breast cancer cell proliferation by interfering with glycerophospholipids and unsaturated fatty acids metabolism., PMID:36147318
Integrative analysis of the roles of lncRNAs and mRNAs in ischaemic preconditioning to alleviate liver ischaemia-reperfusion injury in mice., PMID:36007332
Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly., PMID:35202461
Comprehensive analysis of transcriptomics and metabolomics to illustrate the underlying mechanism of helenalin against hepatic fibrosis., PMID:35120860
Crosstalk of FGFR1 signaling and choline metabolism promotes cell proliferation and survival in prostate cancer cells., PMID:34985768
Hepatocyte nuclear factor-1β shapes the energetic homeostasis of kidney tubule cells., PMID:34653285
Antisense RNAs Influence Promoter Usage of Their Counterpart Sense Genes in Cancer., PMID:34649947
Choline Kinase Alpha Is a Novel Transcriptional Target of the Brg1 in Hepatocyte: Implication in Liver Regeneration., PMID:34422825
Identification of unprecedented ATP-competitive choline kinase inhibitors., PMID:34416377
Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells., PMID:34364639
DNA Methylation of Human Choline Kinase Alpha Promoter-Associated CpG Islands in MCF-7 Cells., PMID:34205960
Gene Expression of CRAL_TRIO Family Proteins modulated by Vitamin E Deficiency in Zebrafish (Danio Rerio)., PMID:34119630
Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets., PMID:34077757
Identification of targets of JS-K against HBV-positive human hepatocellular carcinoma HepG2.2.15 cells with iTRAQ proteomics., PMID:34001947
MicroRNA-367-3p induces apoptosis and suppresses migration of MCF-7 cells by downregulating the expression of human choline kinase α., PMID:33574922
Choline kinase alpha impairment overcomes TRAIL resistance in ovarian cancer cells., PMID:33390181
Comparison of Lesional Juvenile Myositis and Lupus Skin Reveals Overlapping Yet Unique Disease Pathophysiology., PMID:33305541
Involvement of MicroRNA-1-FAM83A Axis Dysfunction in the Growth and Motility of Lung Cancer Cells., PMID:33266425
Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism., PMID:32977218
[Knockdown of choline kinase α (CHKA) inhibits the proliferation, invasion and migration of human U87MG glioma cells]., PMID:32958130
Spatial heterogeneity of radiolabeled choline positron emission tomography in tumors of patients with non-small cell lung cancer: first-in-patient evaluation of [18F]fluoromethyl-(1,2-2H4)-choline., PMID:32754271
ChoK-ing the Pathogenic Bacteria: Potential of Human Choline Kinase Inhibitors as Antimicrobial Agents., PMID:32695809
Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications., PMID:32240714
Elevated Choline Kinase α-Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes., PMID:31826940
Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase., PMID:31745227
De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy., PMID:31517566
KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells., PMID:30629659
Methionine and choline supply alter transmethylation, transsulfuration, and cytidine 5'-diphosphocholine pathways to different extents in isolated primary liver cells from dairy cows., PMID:30316602
Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors., PMID:30043647
EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells., PMID:30006194
Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis., PMID:29737914
For research use only. Not for human or drug use.
