Catalog No.
YHD30701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg232-Arg379
Predicted molecular weight
31.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P18825
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Alpha-2C adrenergic receptor, Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2CAR, ADRA2C, ADRA2L2, ADRA2RL2
The Beta-Blocker Pharmacogenetic Puzzle: More Pieces of Evidence for Pharmacodynamic Candidate Variants., PMID:40285373
Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy., PMID:38951961
Tracing the pathways and mechanisms involved in the anti-breast cancer activity of glycyrrhizin using bioinformatics tools and computational methods., PMID:37042955
Impact of Neuroeffector Adrenergic Receptor Polymorphisms on Incident Ventricular Fibrillation During Acute Myocardial Ischemia., PMID:36926933
Altered Expression of Genes Associated with Major Neurotransmitter Systems in the Reward-Related Brain Regions of Mice with Positive Fighting Experience., PMID:36362437
Long non-coding RNA LINC01018 inhibits human glioma cell proliferation and metastasis by directly targeting miRNA-182-5p., PMID:36094613
Maternal anxiety affects embryo implantation via impairing adrenergic receptor signaling in decidual cells., PMID:35982177
Sex-dependent host-microbiome dynamics in zebrafish: Implications for toxicology and gastrointestinal physiology., PMID:35533547
Mechanism of Jujube (Ziziphus jujuba Mill.) Fruit in the Appetite Regulation Based on Network Pharmacology and Molecular Docking Method., PMID:35480085
Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy., PMID:35258481
Systems Approaches to Unravel Molecular Function: High-content siRNA Screen Identifies TMEM16A Traffic Regulators as Potential Drug Targets for Cystic Fibrosis., PMID:34990652
Exploring the Molecular Mechanism of Astragali Radix-Curcumae Rhizoma against Gastric Intraepithelial Neoplasia by Network Pharmacology and Molecular Docking., PMID:34646329
GPCR Pharmacological Profiling of Aaptamine from the Philippine Sponge Stylissa sp. Extends Its Therapeutic Potential for Noncommunicable Diseases., PMID:34577088
α2A- and α2C-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects., PMID:34237656
Role of α2-Adrenoceptor Subtypes in Suppression of L-Type Ca2+ Current in Mouse Cardiac Myocytes., PMID:33923625
Development of a Novel SNAP-Epitope Tag/Near-Infrared Imaging Assay to Quantify G Protein-Coupled Receptor Degradation in Human Cells., PMID:33402011
Network pharmacology-based study of the molecular mechanisms of Qixuekang in treating COVID-19 during the recovery period., PMID:33165417
Distribution and relative expression of vasoactive receptors on arteries., PMID:32958803
Estrogen increases expression of vascular alpha 2C adrenoceptor through the cAMP/Epac/JNK/AP-1 pathway and potentiates cold-induced vasoconstriction., PMID:32407896
Mechanism underpinning effects of Shichangpu (Rhizoma Acori Tatarinowii) on attention deficit hyperactivity disorder., PMID:32227770
Low free triiodothyronineis predicts worsen neurological outcome of patients with acute ischemic stroke: a retrospective study with bioinformatics analysis., PMID:31690277
Prognostic significance of α- and β2-adrenoceptor gene expression in breast cancer patients., PMID:31218733
Suppression of lymphocyte apoptosis in spleen by CXCL13 after porcine circovirus type 2 infection and regulatory mechanism of CXCL13 expression in pigs., PMID:30819249
Post-treatment with JP-1302 protects against renal ischemia/reperfusion-induced acute kidney injury in rats., PMID:30665845
Label-free drug screening assay multiplexed with an orthogonal time-resolved fluorescence labeled assay., PMID:30452893
Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes., PMID:30354340
The association of an alpha2C adrenoreceptor gene polymorphism with vasomotor symptoms in African American women., PMID:30277919
Differential α2A- and α2C-adrenoceptor protein expression in presynaptic and postsynaptic density fractions of postmortem human prefrontal cortex., PMID:30255728
Inhibition of α2C-adrenoceptors ameliorates cisplatin-induced acute renal failure in rats., PMID:30201375
Selection on the regulation of sympathetic nervous activity in humans and chimpanzees., PMID:29672586
Cardiac safety evaluation in zebrafish and in silico ADME prediction of cephalosporins with an aminothiazoyl ring at the C-7 position., PMID:29596928
Fluoxetine modulates the transcription of genes involved in serotonin, dopamine and adrenergic signalling in zebrafish embryos., PMID:29145140
Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches., PMID:29133212
Evolution of the α2-adrenoreceptors in vertebrates: ADRA2D is absent in mammals and crocodiles., PMID:28622977
[Altered Expression of Neurotransmitters Systems' Genes in the Ventral Tegmental Area of Depressive Male Mice: Data of RNA-Seq]., PMID:30695556
Altered Expression of Genes Encoding Neurotransmitter Receptors in GnRH Neurons of Proestrous Mice., PMID:27774052
Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence., PMID:27007576
Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate., PMID:26739946
Association between Common Genetic Variants of α2A-, α2B-, and α2C-Adrenergic Receptors and Orthostatic Hypotension., PMID:26427149
Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise., PMID:26058836
Differential Pharmacological Regulation of Sensorimotor Gating Deficit in CB1 Knockout Mice and Associated Neurochemical and Histological Alterations., PMID:25895455
Cell-based and virtual fragment screening for adrenergic α2C receptor agonists., PMID:25648685
Specific role of α2A - and α2B -, but not α2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats., PMID:25407049
Adrenergic receptor genotype influences heart failure severity and β-blocker response in children with dilated cardiomyopathy., PMID:25406899
The strong selective sweep candidate gene ADRA2C does not explain domestication related changes in the stress response of chickens., PMID:25111139
Association between common genetic variants of α2A-, α2B- and α2C-adrenoceptors and the risk of silent brain infarction., PMID:24676565
Common α2A and α2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking., PMID:24643471
Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration., PMID:24231350
A general linear model-based approach for inferring selection to climate., PMID:24053227
The C-terminal half of the α2C-adrenoceptor determines the receptor's membrane expression level and drug selectivity., PMID:23868076
For research use only. Not for human or drug use.
