Catalog No.
YHD23201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn30-Gly311
Predicted molecular weight
34.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P17252
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein kinase C alpha type, PKC-A, PKC-alpha, 2.7.11.13, PRKCA, PKCA, PRKACA
Knowledge-guided multi-level network modeling with experimental characterization identifies PRKCA as a novel biomarker and tumor suppressor triggering ferroptosis in prostate cancer., PMID:40391833
Transcriptomic profiling in canine B-cell lymphoma supports a synergistic effect of BTK and PI3K inhibitors., PMID:40351764
A Multi-Level Study on the Anti-Lung Cancer Mechanism of Peiminine, a Key Component of Fritillaria ussuriensis Maxim.: Integrating Quality Analysis, Network Pharmacology, Bioinformatics Analysis, and Experimental Validation., PMID:40331978
Integration of network pharmacology and experimental validation to explore the pharmacological mechanism of andrographolide against asthma., PMID:40198539
Evaluating the Mechanism Underlying Multi-Compound Synergy of Banxia Decoction in the Treatment of Hashimoto's Thyroiditis Based on Network Pharmacology and Molecular Docking., PMID:40196382
Genomic and Transcriptomic Characterization of Protein Kinase C Fusion Melanocytic Neoplasms With Distinctive Hypopigmented Histomorphology: A Single-Institution Study., PMID:40109002
Integrated network pharmacology, proteomics, molecular docking, and experiments in vivo and in vitro to explore the efficacy and potential mechanism of bufalin against hepatocellular carcinoma angiogenesis., PMID:40057142
Novel variants in DNAH17 cause sperm flagellar outer dynein arm defects but not total fertilization failure after ICSI., PMID:40009974
Epigenetic Modulation Directs Recovery Post LASIK and SMILE Surgery: An Experimental Study., PMID:40003656
GW4064 inhibits migration and invasion in human glioblastoma multiforme through the downregulation of PKCα., PMID:39900326
PKCα regulates the secretion of PDL1-carrying small extracellular vesicles in a p53-dependent manner., PMID:39809736
Unraveling the protein kinase C/NDRG1 signaling network in breast cancer., PMID:39736699
Unveiling the substantial role of rutin in the management of drug-induced nephropathy using network pharmacology and molecular docking., PMID:39733639
Pyr3 inhibits cell viability and PKCα activity to suppress migration in human bladder cancer cells., PMID:39725132
Mechanism of Ligusticum wallichii-Borneol in the Treatment of Cerebral Ischemic Stroke in Rats Based On Network Pharmacology, Molecular Docking, and Experimental Verification., PMID:39714965
Metabolomics and network pharmacology-based identification of phenolic acids in Polygonatum kingianum var. grandifolium rhizomes as anti-cancer/Tumor active ingredients., PMID:39689118
AEBP1 Silencing Protects Against Cerebral Ischemia/Reperfusion Injury by Regulating Neuron Ferroptosis and Microglia M2 Polarization Through PRKCA-PI3K-Akt Axis., PMID:39670965
Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma., PMID:39630579
PKCα Activation via the Thyroid Hormone Membrane Receptor Is Key to Thyroid Cancer Growth., PMID:39596225
[Analysis of PIKFYVE gene expression, clinical significance, and experimental validation based on TCGA database in hepatocellular carcinoma]., PMID:39528312
Transcription factor PRRX1-activated ANXA6 facilitates EGFR-PKCα complex formation and enhances cisplatin sensitivity in bladder cancer., PMID:39528080
Transcriptomic analysis of rat prefrontal cortex following chronic stress induced by social isolation - Relevance to psychiatric and neurodevelopmental illness, and implications for treatment., PMID:39502833
Chemogenetic targeting TRPV1 in obesity-induced depression: Unveiling therapeutic potential of eicosapentaenoic acid and acupuncture., PMID:39454693
DNA copy number profiles and systems biology connect chromatin remodeling and DNA repair in high-risk neuroblastoma., PMID:39356132
Unveiling four axes ADAMTS9-AS2|MEG3/hsa-miR-150/PRKCA|MMP14 within prostate cancer through establishment of the ceRNA network., PMID:39341147
Novel therapies for pediatric low grade glioma., PMID:39324939
Identification of miR-20a as a Diagnostic and Prognostic Biomarker in Colorectal Cancer: MicroRNA Sequencing and Machine Learning Analysis., PMID:39318221
Synchronous intracranial arteriovenous malformation and papillary glioneuronal tumour: hypothesis or reality?, PMID:39292231
Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome., PMID:39238930
Multi-omics analysis to reveal the synergistic mechanism underlying the multiple ingredients of Stephania tetrandra extract on rheumatoid arthritis through the PI3K/Akt signaling pathway., PMID:39221139
Comparison of the gene expression profiles of endometrial and trophoblastic cells in women with recurrent miscarriage: A bioinformatics approach., PMID:39205919
The Anti-Metastatic Action of Oxyresveratrol via Suppression of Phosphoryl-ERK/-PKCα-Mediated Sp1/MMP1 Signaling in Human Renal Carcinoma Cells., PMID:39171862
Repeated stress to the skin amplifies neutrophil infiltration in a keratin 17- and PKCα-dependent manner., PMID:39159283
Association between MAPK and PI3K/Akt signaling pathway-related gene polymorphisms and migraine., PMID:39140707
PKCα Induced the Generation of Extracellular Vesicles in Activated Platelets to Promote Breast Cancer Metastasis., PMID:39113702
Pulsatillic acid as a potential inhibitor of protein kinase C-alpha in non-small cell lung cancer., PMID:39097897
Novel dual gene fusions identified in a late pulmonary metastasis of an infantile fibrosarcoma-like tumor., PMID:39078429
Proteomics reveals the pharmacological mechanism of flavonoids from Astragali Complanati Semen in preventing chronic liver injury., PMID:39059265
Identification of novel biomarkers and potential molecular targets for uterine cancer using network-based approach., PMID:39029376
Proteomic and phosphoproteomic profiling of urinary small extracellular vesicles in hepatocellular carcinoma., PMID:38995156
Metabolomic Approach to Identify the Potential Metabolites from Alpinia malaccensis for Treating SARS-CoV-2 Infection., PMID:38955878
ICA1 affects APP processing through the PICK1-PKCα signaling pathway., PMID:38884369
Characterizing Common and Rare Variations in Nontraditional Glycemic Biomarkers Using Multivariate Approaches on Multiancestry ARIC Study., PMID:38869630
Targeting PKCα alleviates iron overload in diabetes and hemochromatosis through the inhibition of ferroportin., PMID:38861671
Multi-modal mechanisms of the metastasis suppressor, NDRG1: Inhibition of WNT/β-catenin signaling by stabilization of protein kinase Cα., PMID:38815861
Transcriptome analysis reveals PRKCA as a potential therapeutic target for overcoming cisplatin resistance in lung cancer through ferroptosis., PMID:38765024
Genetics in neovascular age-related macular degeneration susceptibility and treatment response to anti-VEGF intravitreal injection: A case series study., PMID:38757252
Impinging Flow Mediates Vascular Endothelial Cell Injury through the PKCα/ERK/PPARγ Pathway in vitro., PMID:38688248
Melatonin alleviates endoplasmic reticulum stress to improve ovarian function by regulating the mTOR pathway in aged laying hens., PMID:38631228
[Jianpi Zishen granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study]., PMID:38597437
For research use only. Not for human or drug use.
