Catalog No.
YHC84501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly37-Asn354
Predicted molecular weight
38.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P10915
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hyaluronan and proteoglycan link protein 1, Cartilage-linking protein 1, Cartilage-link protein, Proteoglycan link protein, HAPLN1, CRTL1
[HAPLN1 secreted by synovial fibroblasts in rheumatoid arthritis promotes macrophage polarization towards the M1 phenotype]., PMID:40415620
Identification and functional characterization of hub genes CLTA, EDIL3, HAPLN1, and HIP1 as diagnostic biomarkers and therapeutic targets in thyroid cancer and Hashimoto's thyroiditis., PMID:40372556
Comprehensive bioinformatics analysis of hub genes in ischemic heart failure and atrial fibrillation., PMID:40066352
Extracellular baskets in inner hair cells and perineuronal nets in auditory nerves: Changes in noise-induced hearing loss rats., PMID:39922528
Effects of GDF6 on active protein synthesis by cells of degenerated intervertebral disc., PMID:39920317
Changes in Gene Expression of the Extracellular Matrix in Patients with Full-Thickness Rotator Cuff Tears of Varying Sizes., PMID:39912080
Multiplexed immunoassay for a serum autoantibody biomarker panel in diagnostic and prognostic prediction of canine mammary tumors., PMID:39639821
Microglia phagocytosis of PNNs mediates PV-positive interneuron dysfunction and associated gamma oscillations in neuroinflammation-induced cognitive impairment in mice., PMID:39489286
Analysis of ANO6, HAPLN1, and EDIL3 Polymorphisms in Patients with Ankylosing Spondylitis in a Chinese Han Population: A Case-Control Study., PMID:39358671
Dynamic Organization of Neuronal Extracellular Matrix Revealed by HaloTag-HAPLN1., PMID:39251350
Hyaluronan and proteoglycan link protein 1 - A novel signaling molecule for rejuvenating aged skin., PMID:39226945
An Eye into the Aorta: The Role of Extracellular Matrix Regulatory Genes ZNF469 and PRDM5, from Their Previous Association with Brittle Cornea Syndrome to Their Novel Association with Aortic and Arterial Aneurysmal Diseases., PMID:38892036
Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping., PMID:38618242
The effects of hyaluronan and proteoglycan link protein 1 (HAPLN1) in ameliorating spinal cord injury mediated by Nrf2., PMID:38607990
Novel extracellular matrix architecture on excitatory neurons revealed by HaloTag-HAPLN1., PMID:38585814
HAPLN1 knockdown inhibits heart failure development via activating the PKA signaling pathway., PMID:38580957
Association of hyaluronan and proteoglycan link protein 1 gene with the need of home oxygen therapy in premature Japanese infants with bronchopulmonary dysplasia., PMID:38522947
Developmental patterns of extracellular matrix molecules in the embryonic and postnatal mouse hindbrain., PMID:38496826
Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma., PMID:38472454
Comparison of sialylated and fucosylated N-glycans attached to Asn 6 and Asn 41 with different roles in hyaluronan and proteoglycan link protein 1 (HAPLN1)., PMID:38246450
Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1 in vitro and in vivo., PMID:38076839
Linking epileptic phenotypes and neural extracellular matrix remodeling signatures in mouse models of epilepsy., PMID:37838005
FKBP5 regulates trophoblast-macrophage crosstalk in recurrent spontaneous abortion through PI3K/AKT and NF-κB signaling pathways., PMID:37827456
Identification of potential circadian genes and associated pathways in colorectal cancer progression and prognosis using microarray gene expression analysis., PMID:37709376
HAPLN1 matrikine: a bone marrow homing factor linked to poor outcomes in patients with MM., PMID:37647592
Recombinant Human HAPLN1 Mitigates Pulmonary Emphysema by Increasing TGF-β Receptor I and Sirtuins Levels in Human Alveolar Epithelial Cells., PMID:37587649
A Novel Role of Hyaluronic Acid and Proteoglycan Link Protein 1 (HAPLN1) in Delaying Vascular Endothelial Cell Senescence., PMID:37551651
Novel Effect of Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) on Hair Follicle Cells Proliferation and Hair Growth., PMID:37551604
ASPN Synergizes with HAPLN1 to Inhibit the Osteogenic Differentiation of Bone Marrow Mesenchymal Stromal Cells and Extracellular Matrix Mineralization of Osteoblasts., PMID:37427673
Hyaluronic acid and proteoglycan link protein 1 suppresses platelet‑derived growth factor-BB-induced proliferation, migration, and phenotypic switching of vascular smooth muscle cells., PMID:37401239
HAPLN1 potentiates peritoneal metastasis in pancreatic cancer., PMID:37095087
Extracellular Matrix Changes in Subcellular Brain Fractions and Cerebrospinal Fluid of Alzheimer's Disease Patients., PMID:36982604
Extremely low-frequency electromagnetic field (ELF-EMF) induces alterations in epigenetic regulation in the myometrium - An in vitro study., PMID:36806924
Hyaluronan and Proteoglycan Link Protein 1 Activates the BMP4/Smad1/5/8 Signaling Pathway to Promote Osteogenic Differentiation: an Implication in Fracture Healing., PMID:36737556
Ectopic CH60 mediates HAPLN1-induced cell survival signaling in multiple myeloma., PMID:36625202
HAPLN1 confers multiple myeloma cell resistance to several classes of therapeutic drugs., PMID:36480501
Gastric Cancer Derived Mesenchymal Stem Cells Promote the Migration of Gastric Cancer Cells Through miR-374a-5p., PMID:36424798
Noncovalent hyaluronan crosslinking by TSG-6: Modulation by heparin, heparan sulfate, and PRG4., PMID:36275631
Progressive Transcriptional Changes in the Amygdala Implicate Neuroinflammation in the Effects of Repetitive Low-Level Blast Exposure in Male Rats., PMID:36262047
The Implication of Serum Autoantibodies in Prognosis of Canine Mammary Tumors., PMID:36139323
Identification of candidate enhancers controlling the transcriptome during the formation of interphalangeal joints., PMID:35896673
Transcriptional profiling reveals roles of intercellular Fgf9 signaling in astrocyte maturation and synaptic refinement during brainstem development., PMID:35753346
HAPLN1 Affects Cell Viability and Promotes the Pro-Inflammatory Phenotype of Fibroblast-Like Synoviocytes., PMID:35720292
hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration., PMID:35652354
A Hyaluronan and Proteoglycan Link Protein 1 Matrikine: Role of Matrix Metalloproteinase 2 in Multiple Myeloma NF-κB Activation and Drug Resistance., PMID:35604822
Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling., PMID:35504345
The Effects of TNF-α Inhibition on the Metabolism of Cartilage: Relationship between KS, HA, HAPLN1 and ADAMTS4, ADAMTS5, TOS and TGF-β1 Plasma Concentrations in Patients with Juvenile Idiopathic Arthritis., PMID:35407621
Genome Wide Scan to Identify Potential Genomic Regions Associated With Milk Protein and Minerals in Vrindavani Cattle., PMID:35359668
Loss of Hyaluronan and Proteoglycan Link Protein-1 Induces Tumorigenesis in Colorectal Cancer., PMID:34966673
Proteomic analysis of serum in workers exposed to diesel engine exhaust., PMID:34894159
For research use only. Not for human or drug use.
