Catalog No.
YHC73101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Phe133
Predicted molecular weight
17.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P0DPB6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA-directed RNA polymerases I and III subunit RPAC2, RNA polymerases I and III subunit AC2, AC19, DNA-directed RNA polymerase I subunit D, RNA polymerase I 16 kDa subunit, RPA16, RPC16, hRPA19, POLR1D
POLR1D, a shared subunit of RNA polymerase I and III, modulates mTORC1 activity., PMID:40222657
Molecular and Clinical Heterogeneity in Hungarian Patients with Treacher Collins Syndrome-Identification of Two Novel Mutations by Next-Generation Sequencing., PMID:39518953
[Treacher Collins Syndrome 2 caused by a novel pathogenic variant in PLOR1D: clinical report and literature review]., PMID:39289962
Transcriptional genes of lysosome-associated membrane protein 2A in sciatic nerve injuries by bioinformatics., PMID:38935077
POLR1D silencing suppresses lung cancer cells proliferation and migration via inhibition of PI3K-Akt pathway., PMID:38844975
Higher expression of TSR2 aggravating hypertension via the PPAR signaling pathway., PMID:38814181
RNA polymerase I subunit D activated by Yin Yang 1 transcription promote cell proliferation and angiogenesis of colorectal cancer cells., PMID:38682174
Alcohol Exposure Induces Nucleolar Stress and Apoptosis in Mouse Neural Stem Cells and Late-Term Fetal Brain., PMID:38474404
Identification and Validation of a Prognostic Signature Derived from the Cancer Stem Cells for Oral Squamous Cell Carcinoma., PMID:38256104
Screening and Identifying Reference Genes for Erythrocyte Production from Cord Blood CD34+ Cells Exposed to Hypoxia., PMID:38011643
Clinical and molecular study of Egyptian patients with Treacher Collins syndrome., PMID:37646764
Distinct Interaction Modes for the Eukaryotic RNA Polymerase Alpha-like Subunits., PMID:37222571
A systematic review on Treacher Collins syndrome: Correlation between molecular genetic findings and clinical severity., PMID:36203321
A clinically-relevant residue of POLR1D is required for Drosophila development., PMID:35656583
Treacher Collins Syndrome: Genetics, Clinical Features and Management., PMID:34573374
Phenotype Analysis and Genetic Study of Chinese Patients With Treacher Collins Syndrome., PMID:34397304
A novel nonsense mutation in the TCOF1 gene in one Chinese newborn with Treacher Collins syndrome., PMID:33341718
Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice., PMID:33022126
Identification of Biomarkers to Construct a Competing Endogenous RNA Network and Establishment of a Genomic-Clinicopathologic Nomogram to Predict Survival for Children with Rhabdoid Tumors of the Kidney., PMID:32908900
Broad-spectrum next-generation sequencing-based diagnosis of a case of Nager syndrome., PMID:32537850
Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer., PMID:32087735
Retrospective study of Langerhans cell histiocytosis in ear, nose and neck., PMID:31870640
Expression and Clinical Significance of POLR1D in Colorectal Cancer., PMID:31722331
POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4., PMID:31649276
TCOF1 pathogenic variants identified by Whole-exome sequencing in Chinese Treacher Collins syndrome families and hearing rehabilitation effect., PMID:31307516
[Pathogenic genes and clinical therapeutic strategies for Treacher Collins syndrome]., PMID:31218872
Identification of potential diagnostic biomarkers for Parkinson's disease., PMID:31199560
Genotype-phenotype variability in Chinese cases of Treacher Collins syndrome., PMID:31107123
Autosomal recessive Treacher Collins syndrome due to POLR1C mutations: Report of a new family and review of the literature., PMID:30957429
POLR1D promotes colorectal cancer progression and predicts poor prognosis of patients., PMID:30582221
Polymerase-1 pathway activation in acute multiple sclerosis relapse., PMID:30316990
Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders., PMID:29364875
Mutation screening of Chinese Treacher Collins syndrome patients identified novel TCOF1 mutations., PMID:29230583
Treacher Collins syndrome mutations in Saccharomyces cerevisiae destabilize RNA polymerase I and III complex integrity., PMID:28973381
Experimental Autoimmune Encephalomyelitis Ameliorated by Passive Transfer of Polymerase 1-Silenced MOG35-55 Lymphatic Node Cells: Verification of a Novel Therapeutic Approach in Multiple Sclerosis., PMID:28755038
The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome., PMID:27448281
[The research progress of Treacher Collins syndrome]., PMID:27373049
Pathogenesis of POLR1C-dependent Type 3 Treacher Collins Syndrome revealed by a zebrafish model., PMID:26972049
Treacher Collins syndrome: a clinical and molecular study based on a large series of patients., PMID:25790162
Whole exome sequencing identifies a POLRID mutation segregating in a father and two daughters with findings of Klippel-Feil and Treacher Collins syndromes., PMID:25348728
Treacher Collins Syndrome: the genetics of a craniofacial disease., PMID:24690222
Autosomal recessive POLR1D mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome., PMID:24603435
A novel mutation in the TCOF1 gene found in two Chinese cases of Treacher Collins syndrome., PMID:23838542
Two extraordinarily severe cases of Treacher Collins syndrome., PMID:23401420
Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer., PMID:23319804
Suppressed RNA-polymerase 1 pathway is associated with benign multiple sclerosis., PMID:23077530
Treacher Collins syndrome: clinical implications for the paediatrician--a new mutation in a severely affected newborn and comparison with three further patients with the same mutation, and review of the literature., PMID:22729243
Occurrence of complete arhinia in two siblings with a clinical picture of Treacher Collins syndrome negative for TCOF1, POLR1D and POLR1C mutations., PMID:21772136
Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome., PMID:21131976
For research use only. Not for human or drug use.
