Catalog No.
YHC28301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser16-Ala85
Predicted molecular weight
19.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07910
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Heterogeneous nuclear ribonucleoproteins C1/C2, hnRNP C1/C2, HNRNPC, HNRPC
HNRNPC promotes keloid progression via modulating the stability of m6A-modified WDR77 mRNA and expression of TGF-β and SMAD3., PMID:40484365
Gobal crotonylome reveals that HNRNPC and its crotonylation promote p53-deficient tumor growth by stabilizing CCND1 and MCM3 mRNAs., PMID:40482911
Thermodynamic insights into N6-methyladenosine-modified ribonucleic acids and their interactions with the RNA recognition motif of heterogeneous nuclear ribonucleoprotein C., PMID:40373918
Complement C5a promotes human retinal pigment epithelial cell viability and migration through SLC38A1-mediated glutamine metabolism., PMID:40358757
The anti-metastatic effect of elemene in human hepatocellular carcinoma is potentially mediated by inhibiting a novel driver-circBPTF., PMID:40347926
Targeting PSMD14 combined with arachidonic acid induces synthetic lethality via FADS1 m6A modification in triple-negative breast cancer., PMID:40344056
Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD., PMID:40291645
HNRNPC stabilizes m6A-modified AC145207.5 to accelerate tumorigenesis in colorectal cancer by impeding the Nrf2/GPX4 axis-mediated ferroptosis., PMID:40290566
irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA., PMID:40140581
Optical genome mapping identifies rare structural variants in neural tube defects., PMID:40107724
HNRNPC promotes progression of non-small cell lung cancer by maintaining TFAP2A mRNA stability., PMID:40057699
RALYL Overexpression Suppresses Colorectal Cancer via Modulating HNRNPC-Mediated MNK2 Alternative Splicing., PMID:40052233
Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity., PMID:40037142
HnRNPC triggers the degradation of MITA to suppress the interferon-mediated antiviral response., PMID:39994817
DHX9 helicase impacts on splicing decisions by modulating U2 snRNP recruitment in Ewing sarcoma cells., PMID:39950342
Immediate early splicing controls translation in activated T-cells and is mediated by hnRNPC2 phosphorylation., PMID:39948410
hnRNPC Functions with HuR to Regulate Alternative Splicing in an m6A-Dependent Manner and is Essential for Meiosis., PMID:39921484
Heterogeneous nuclear ribonucleoprotein C promotes non-small cell lung cancer progression by enhancing XB130 mRNA stability and translation., PMID:39800708
circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4., PMID:39748364
HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation., PMID:39735682
m6A-related genes ALKBH5 and RBMX as prognostic and progression biomarkers in Chinese oral squamous cell carcinoma patients., PMID:39643954
Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying Circ-Tulp4 Attenuate Diabetes Mellitus with Nonalcoholic Fatty Liver Disease by Inhibiting Cell Pyroptosis through the HNRNPC/ABHD6 Axis., PMID:39546192
Dysregulated inclusion of BOLA3 exon 3 promoted by HNRNPC accelerates the progression of esophageal squamous cell carcinoma., PMID:39455467
Role of Circular RNA MMP9 in Glioblastoma Progression: From Interaction With hnRNPC and hnRNPA1 to Affecting the Expression of BIRC5 by Sequestering miR-149., PMID:39401767
irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein associations on RNA., PMID:39386644
HNRNPC modulates PKM alternative splicing via m6A methylation, upregulating PKM2 expression to promote aerobic glycolysis in papillary thyroid carcinoma and drive malignant progression., PMID:39380010
HNRNPC mediates lymphatic metastasis of cervical cancer through m6A-dependent alternative splicing of FOXM1., PMID:39375330
Decellularized adipose-derived matrix from Superficial layers of abdominal adipose tissue exhibits superior capacity of adipogenesis compared to deep layers., PMID:39318374
TARGET based m6A methylation-related genes predict prognosis relapsed B-cell acute lymphoblastic leukemia., PMID:39251964
Interdependent regulation of alternative splicing by SR and hnRNP proteins., PMID:39229091
Identification and Prognostic Value of m6A-Related Genes in Glioblastoma., PMID:39216042
TGF-β-induced lncRNA TBUR1 promotes EMT and metastasis in lung adenocarcinoma via hnRNPC-mediated GRB2 mRNA stabilization., PMID:39102940
JAK and STAT5B mediate olfactory response of migratory locusts to their own volatiles., PMID:39068995
Consensus clustering and novel risk score model construction based on m6A methylation regulators to evaluate the prognosis and tumor immune microenvironment of early-stage lung adenocarcinoma., PMID:39028290
Identification of RNA-binding protein hnRNP C targeting the 3'UTR of the TAP-associated glycoprotein tapasin in melanoma., PMID:38948930
m6A Reader HNRNPC Facilitates Adipogenesis by Regulating Cytoskeletal Remodeling through Enhanced Lcp1 mRNA Stability., PMID:38916731
ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins., PMID:38896448
A HNRNPC::RARB variant of acute promyelocytic leukemia with concurrent myeloid sarcoma of the spine., PMID:38864905
The m6A reader HNRNPC promotes glioma progression by enhancing the stability of IRAK1 mRNA through the MAPK pathway., PMID:38830885
TFAIP6 facilitates hepatocellular carcinoma cell glycolysis through upregulating c-myc/PKM2 axis., PMID:38813227
Cancer-derived exosomal lncRNA SNHG3 promotes the metastasis of colorectal cancer through hnRNPC-mediating RNA stability of β-catenin., PMID:38725844
Sertoli cells require hnRNPC to support normal spermatogenesis and male fertility in mice†., PMID:38590182
DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus., PMID:38538536
NME6 as a potential biomarker and therapeutic target involved in immune infiltration for lung adenocarcinoma., PMID:38517815
HNRNPC Regulates GLUT1/LDHA Pathway by Stabilizing FOXM1 mRNA to Promote the Progression and Aerobic Glycolysis of Multiple Myeloma., PMID:38514068
Identification of splicing factors signature predicting prognosis risk and the mechanistic roles of novel oncogenes in HNSCC., PMID:38458543
Radiogenomic analysis of ultrasound phenotypic features coupled to proteomes predicts metastatic risk in primary prostate cancer., PMID:38438956
Construction and validation of m6A-related diagnostic model for psoriasis., PMID:38436011
Role of Optimization in RNA-Protein-Binding Prediction., PMID:38392205
HNRNPC promotes estrogen receptor-positive breast cancer cell cycle by stabilizing WDR77 mRNA in an m6A-dependent manner., PMID:38353359