Catalog No.
YHC18001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly29-Gln215
Predicted molecular weight
24.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P05813
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Beta-crystallin A3, Beta-crystallin A3, isoform A1, Delta4 form, Beta-crystallin A3, isoform A1, Delta7 form, Beta-crystallin A3, isoform A1, Delta8 form, CRYBA1, CRYB1
MLST8 overexpression in RPE cells disrupts autophagy through novel mechanisms affecting AMD pathogenesis., PMID:40205682
ANXA5 predicts prognosis and immune response and mediates proliferation and migration in head and neck squamous cell carcinoma., PMID:39168258
Identification of spontaneous age-related cataract in Microtus fortis., PMID:39019784
Mitophagy in Astrocytes Is Required for the Health of Optic Nerve., PMID:37887340
Screening the pathogenic causes of congenital cataract via whole exome sequencing technology in three families: Molecular genetics of congenital cataract., PMID:37165913
Lens-specific βA3/A1-conditional knockout mice: Phenotypic characteristics and calpain activation causing protein degradation and insolubilization., PMID:36989286
Deciphering local adaptation of native Indian cattle (Bos indicus) breeds using landscape genomics and in-silico prediction of deleterious SNP effects on protein structure and function., PMID:36816754
HER2 Overexpression and Cytogenetical Patterns in Canine Mammary Carcinomas., PMID:36356060
Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD., PMID:35473441
Patterns of Crystallin Gene Expression in Differentiation State Specific Regions of the Embryonic Chicken Lens., PMID:35412582
Cataract-causing G91del mutant destabilised βA3 heteromers formation linking with structural stability and cellular viability., PMID:34489339
Pathogenic mechanism of congenital cataract caused by the CRYBA1/A3-G91del variant and related intervention strategies., PMID:34419537
βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells., PMID:34239035
A novel missense mutation of CRYBA1 in a northern Chinese family with inherited coronary cataract with blue punctate opacities., PMID:33827296
βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity., PMID:33627831
The genetic landscape of crystallins in congenital cataract., PMID:33243271
Improvement of opsoclonus after congenital cataract surgery in an infant., PMID:31957102
Mutation screening of crystallin genes in Chinese families with congenital cataracts., PMID:31523120
The identification and characterization of the p.G91 deletion in CRYBA1 in a Chinese family with congenital cataracts., PMID:31488069
Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease., PMID:31462148
A novel MAF missense mutation leads to congenital nuclear cataract by impacting the transactivation of crystallin and noncrystallin genes., PMID:30659945
Speciation in a biodiversity hotspot: Phylogenetic relationships, species delimitation, and divergence times of Patagonian ground frogs from the Eupsophus roseus group (Alsodidae)., PMID:30543633
A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration., PMID:30098172
Clinical and genetic characteristics of Chinese patients with familial or sporadic pediatric cataract., PMID:29914532
Photoreceptor-induced RPE phagolysosomal maturation defects in Stargardt-like Maculopathy (STGD3)., PMID:29654292
Retinal genes are differentially expressed in areas of primary versus secondary degeneration following partial optic nerve injury., PMID:29425209
Mutation Analysis of Families with Autosomal Dominant Congenital Cataract: A Recurrent Mutation in the CRYBA1/A3 Gene Causing Congenital Nuclear Cataract., PMID:29364738
Synthesis of Recombinant Mouse Crystallin Proteins and in Vitro Measurement of Their Refractivity., PMID:33429617
Development and clinical utility of a novel diagnostic nystagmus gene panel using targeted next-generation sequencing., PMID:28378818
Identification of a De Novo 3bp Deletion in CRYBA1/A3 Gene in Autosomal Dominant Congenital Cataract., PMID:28120589
The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling., PMID:28083894
CRYβA3/A1-Crystallin Knockout Develops Nuclear Cataract and Causes Impaired Lysosomal Cargo Clearance and Calpain Activation., PMID:26863613
Human βA3/A1-crystallin splicing mutation causes cataracts by activating the unfolded protein response and inducing apoptosis in differentiating lens fiber cells., PMID:26851658
Phenotypes of Recessive Pediatric Cataract in a Cohort of Children with Identified Homozygous Gene Mutations (An American Ophthalmological Society Thesis)., PMID:26622071
Modulation of V-ATPase by βA3/A1-Crystallin in Retinal Pigment Epithelial Cells., PMID:26427489
Lysosomes: Regulators of autophagy in the retinal pigmented epithelium., PMID:26321509
Establishment of a recessive mutant small-eye rat with lens involution and retinal detachment associated with partial deletion and rearrangement of the Cryba1 gene., PMID:26303524
βA3/A1-crystallin and persistent fetal vasculature (PFV) disease of the eye., PMID:26022148
βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes., PMID:25736717
βA3/A1-crystallin: more than a lens protein., PMID:25461968
Alpha B- and βA3-crystallins containing d-aspartic acids exist in a monomeric state., PMID:25450505
Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response., PMID:25257511
Differential effect of cataract-associated mutations in MAF on transactivation of MAF target genes., PMID:25064449
Congenital cataracts due to a novel 2‑bp deletion in CRYBA1/A3., PMID:24926697
Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling., PMID:24468901
Molecular and structural analysis of genetic variations in congenital cataract., PMID:24319337
Long-term neuroprotective effects of NT-4-engineered mesenchymal stem cells injected intravitreally in a mouse model of acute retinal injury., PMID:24265016
A crystallin gene network in the mouse retina., PMID:23978599
A CRYGC gene mutation associated with autosomal dominant pulverulent cataract., PMID:23954869
p53 directly regulates αA- and βA3/A1-crystallin genes to modulate lens differentiation., PMID:23745585
For research use only. Not for human or drug use.
