Catalog No.
YHB79601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser494-Lys706
Predicted molecular weight
25.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95932
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein-glutamine gamma-glutamyltransferase 6, 2.3.2.13, Transglutaminase Y, TGY, TGase Y, Transglutaminase-3-like, TGase-3-like, Transglutaminase-6, TG6, TGase-6, TGM6, TGM3L
Serological analysis of gluten-related antibodies in idiopathic neuropathies and cerebellar ataxia., PMID:40481865
Cytokines from parasites: manipulating host responses by molecular mimicry., PMID:40302223
CSF Markers of TG6 Autoimmunity in Gluten Ataxia., PMID:40172737
TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts., PMID:39984487
The Evolution of Transglutaminases Underlies the Origin and Loss of Cornified Skin Appendages in Vertebrates., PMID:38781495
TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblasts., PMID:38187573
[Association between anti-tissue transglutaminase antibody titers and duodenal histopathology among adults with celiac disease]., PMID:36746530
Application of a custom NGS gene panel revealed a high diagnostic utility for molecular testing of hereditary ataxias., PMID:35588347
Neither a Novel Tau Proteinopathy nor an Expansion of a Phenotype: Reappraising Clinicopathology-Based Nosology., PMID:34298918
Network analysis of potential risk genes for psoriasis., PMID:34134787
TGM6 might not be a specific causative gene for spinocerebellar ataxia resulting from genetic analysis and functional study., PMID:33588035
TG6 Auto-Antibodies in Dermatitis Herpetiformis., PMID:32967363
Dietary Gluten and Neurodegeneration: A Case for Preclinical Studies., PMID:32751379
TGM6 variants in Parkinson's disease: clinical findings and functional evidence., PMID:32259886
Epilepsy, cerebral calcifications, and gluten-related disorders: Are anti-transglutaminase 6 antibodies the missing link?, PMID:31698178
Neurologic Deficits in Patients With Newly Diagnosed Celiac Disease Are Frequent and Linked With Autoimmunity to Transglutaminase 6., PMID:30885888
Candidate genes involved in metastasis of colon cancer identified by integrated analysis., PMID:30884206
Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese., PMID:30287856
Hispanic Spinocerebellar Ataxia Type 35 (SCA35) with a Novel Frameshift Mutation., PMID:30229425
Autoantibodies in the Extraintestinal Manifestations of Celiac Disease., PMID:30127251
Genetic Variants Associated with Episodic Ataxia in Korea., PMID:29062094
Mutations in TGM6 induce the unfolded protein response in SCA35., PMID:28934387
TGM6 gene mutations in undiagnosed cerebellar ataxia patients., PMID:28927799
Transglutaminase 6 antibodies in gluten neuropathy., PMID:28886934
[Gluten Ataxia: Anti-Transglutaminase-6 Antibody as a New Biomarker]., PMID:28819077
Anti-transglutaminase 6 Antibody Development in Children With Celiac Disease Correlates With Duration of Gluten Exposure., PMID:28542044
Transglutaminase-6 is an autoantigen in progressive multiple sclerosis and is upregulated in reactive astrocytes., PMID:28273770
SCA 35 presenting as isolated treatment-resistant dystonic hand tremor., PMID:28214262
No association between gluten sensitivity and amyotrophic lateral sclerosis., PMID:28168522
[A case considered gluten ataxia with anti-TG6 IgA antibodies]., PMID:27212675
Transglutaminase 6 Antibodies in the Serum of Patients With Amyotrophic Lateral Sclerosis., PMID:25867286
Spinocerebellar ataxia 35: novel mutations in TGM6 with clinical and genetic characterization., PMID:25253745
Positional cloning and next-generation sequencing identified a TGM6 mutation in a large Chinese pedigree with acute myeloid leukaemia., PMID:24755948
Gluten ataxia of sporadic and hereditary cerebellar ataxia in patients from mainland China., PMID:23860139
Distribution of transglutaminase 6 in the central nervous system of adult mice., PMID:23836538
Transglutaminase 6 interacts with polyQ proteins and promotes the formation of polyQ aggregates., PMID:23800413
Transglutaminase 6 antibodies in the diagnosis of gluten ataxia., PMID:23576621
Identification of a highly reactive substrate peptide for transglutaminase 6 and its use in detecting transglutaminase activity in the skin epidermis., PMID:23331848
Spinocerebellar ataxia type 35 (SCA35)-associated transglutaminase 6 mutants sensitize cells to apoptosis., PMID:23206699
Coeliac disease, epilepsy, and cerebral calcifications: association with TG6 autoantibodies., PMID:22845673
Whole exome sequencing identifies a novel mutation in the transglutaminase 6 gene for spinocerebellar ataxia in a Chinese family., PMID:22554020
Increased prevalence of transglutaminase 6 antibodies in sera from schizophrenia patients., PMID:22516148
Mutations in rare ataxia genes are uncommon causes of sporadic cerebellar ataxia., PMID:22287014
Transglutaminase 6: a protein associated with central nervous system development and motor function., PMID:21984379
Human inter-α-inhibitor is a substrate for factor XIIIa and tissue transglutaminase., PMID:21939789
Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement., PMID:21683323
IgA-class autoantibodies against neuronal transglutaminase, TG6 in celiac disease: no evidence for gluten dependency., PMID:21453693
TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing., PMID:21106500
Gluten sensitivity and the CNS: diagnosis and treatment., PMID:20610339
For research use only. Not for human or drug use.
