Catalog No.
YHB69301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile23-Ala254
Predicted molecular weight
27.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95571
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Persulfide dioxygenase ETHE1, mitochondrial, 1.13.11.18, Ethylmalonic encephalopathy protein 1, Hepatoma subtracted clone one protein, Sulfur dioxygenase ETHE1, ETHE1, HSCO
Targeting ETHE1 inhibits tumorigenesis in vitro and in vivo by preventing aerobic glycolysis in gastric adenocarcinoma cells., PMID:40264823
Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk., PMID:39863625
Mitigation of depleted uranium-induced mitochondrial damage by ethylmalonic encephalopathy 1 protein via modulation of hydrogen sulfide and glutathione pathways., PMID:39729112
Emerging roles of hydrogen sulfide-metabolizing enzymes in cancer., PMID:39643979
ETHE1 dampens colorectal cancer angiogenesis by promoting TC45 Dephosphorylation of STAT3 to inhibit VEGF-A expression., PMID:39198402
Phosphorylated FOXQ1, a novel substrate of JNK1, inhibits sorafenib-induced ferroptosis by activating ETHE1 in hepatocellular carcinoma., PMID:38839744
A Comprehensive Prognostic Model for Colon Adenocarcinoma Depending on Nuclear-Mitochondrial-Related Genes., PMID:38832431
Curcumin reduces myocardial ischemia-reperfusion injury, by increasing endogenous H2S levels and further modulating m6A., PMID:38643323
Circulating Biomarkers and Risk of Hypertension: A Two-Sample Mendelian Randomisation Study., PMID:38042639
Stimulus-responsive proteins involved in multi-process regulation of storage substance accumulation during rice grain filling under elevated temperature., PMID:37936114
ETHE1 Accelerates Triple-Negative Breast Cancer Metastasis by Activating GCN2/eIF2α/ATF4 Signaling., PMID:37834012
Role of Cystathionine β-Synthase and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics of Murine Breast Cancer Cells., PMID:36978895
An atypically mild case of ethylmalonic encephalopathy with pathogenic ETHE1 variant., PMID:36891747
Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: Altered biogenesis and mitochondrial metabolism of H2S lead to H2S deficiency in calcific aortic valve disease., PMID:36780769
Depleted uranium causes renal mitochondrial dysfunction through the ETHE1/Nrf2 pathway., PMID:36681261
Hydrogen Sulfide Metabolizing Enzymes in the Intestinal Mucosa in Pediatric and Adult Inflammatory Bowel Disease., PMID:36421421
Sequential Accumulation of 'Driver' Pathway Mutations Induces the Upregulation of Hydrogen-Sulfide-Producing Enzymes in Human Colonic Epithelial Cell Organoids., PMID:36139896
Next-generation sequencing of Tunisian Leigh syndrome patients reveals novel variations: impact for diagnosis and treatment., PMID:36093993
Ethylmalonic encephalopathy masquerading as meningococcemia., PMID:35165146
Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation., PMID:34737229
Ethylmalonic Encephalopathy 1 Protein Is Increased in Colorectal Adenocarcinoma., PMID:34593420
Systems Biomedicine of Primary and Metastatic Colorectal Cancer Reveals Potential Therapeutic Targets., PMID:34249670
Ethylmalonic encephalopathy and liver transplantation: long-term outcome of the first treated patient., PMID:34011365
Ethylmalonic encephalopathy ETHE1 p. D165H mutation alters the mitochondrial function in human skeletal muscle proteome., PMID:33639274
Ethylmalonic encephalopathy 1 initiates overactive autophagy in depleted uranium-induced cytotoxicity in the human embryonic kidney 293 cells., PMID:33274826
Compromised therapeutic value of pediatric liver transplantation in ethylmalonic encephalopathy: A case report., PMID:33177801
Mitochondrial Dysfunction and Redox Homeostasis Impairment as Pathomechanisms of Brain Damage in Ethylmalonic Encephalopathy: Insights from Animal and Human Studies., PMID:33034777
Ethylmalonic encephalopathy: Clinical course and therapy response in an uncommon mild case with a severe ETHE1 mutation., PMID:32923369
Identification of a novel homozygous nonsense variant in a Chinese patient with ethylmalonic encephalopathy and a genotype-phenotype spectrum review., PMID:32485156
Mystery Case: An infant with developmental delay, epileptic spasms, and acrocyanosis., PMID:32366539
Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells., PMID:32183148
HIF-1 Has a Central Role in Caenorhabditis elegans Organismal Response to Selenium., PMID:32161616
Child Neurology: Ethylmalonic encephalopathy., PMID:32111695
ETHE1 and MOCS1 deficiencies: Disruption of mitochondrial bioenergetics, dynamics, redox homeostasis and endoplasmic reticulum-mitochondria crosstalk in patient fibroblasts., PMID:31477743
ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer., PMID:31258845
Improved clinical outcome following liver transplant in patients with ethylmalonic encephalopathy., PMID:30864297
Evidence that thiol group modification and reactive oxygen species are involved in hydrogen sulfide-induced mitochondrial permeability transition pore opening in rat cerebellum., PMID:30399433
Deficiency of the mitochondrial sulfide regulator ETHE1 disturbs cell growth, glutathione level and causes proteome alterations outside mitochondria., PMID:30391543
Spectroscopic and Electronic Structure Study of ETHE1: Elucidating the Factors Influencing Sulfur Oxidation and Oxygenation in Mononuclear Nonheme Iron Enzymes., PMID:30362717
[Clinical and genetic analysis of a case with atypical ethyl malonate encephalopathy]., PMID:30298498
Persulfide Dioxygenase From Acidithiobacillus caldus: Variable Roles of Cysteine Residues and Hydrogen Bond Networks of the Active Site., PMID:30072973
Evidence that Thiosulfate Inhibits Creatine Kinase Activity in Rat Striatum via Thiol Group Oxidation., PMID:30056533
Mechanism-based inhibition of human persulfide dioxygenase by γ-glutamyl-homocysteinyl-glycine., PMID:29980601
Identification of pathways and genes associated with synovitis in osteoarthritis using bioinformatics analyses., PMID:29968759
Further dissection of QTLs for salt-induced stroke and identification of candidate genes in the stroke-prone spontaneously hypertensive rat., PMID:29925869
Response to medical and a novel dietary treatment in newborn screen identified patients with ethylmalonic encephalopathy., PMID:29526615
hsa-miR-29c-3p regulates biological function of colorectal cancer by targeting SPARC., PMID:29262657
Ethylmalonic Aciduria in an Infant with Neurological and Skin Presentation., PMID:29089323
Identification of Serological Biomarkers for Early Diagnosis of Lung Cancer Using a Protein Array-Based Approach., PMID:29021294
For research use only. Not for human or drug use.
