Catalog No.
YHB65301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His26-Ile164
Predicted molecular weight
17.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95433
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Activator of 90 kDa heat shock protein ATPase homolog 1, AHA1, p38, AHSA1, C14orf3, HSPC322
Benzbromarone interferes with the interaction between Hsp90 and Aha1 by interacting with both of them., PMID:40379881
UPP1 and AHSA1 as emerging biomarkers and targets in pancreatic cancer: A proteomic approach., PMID:40358702
AHSA1-HSP90AA1 complex stabilized IFI6 and TGFB1 promotes mitochondrial stability and EMT in EGFR-mutated lung adenocarcinoma under Osimertinib pressure., PMID:40234395
A Six-Gene Signature Related to Liquid-Liquid Phase Separation for Diagnosis of Alzheimer's Disease., PMID:39665604
Modification of Regulatory Tyrosine Residues Biases Human Hsp90α in its Interactions with Cochaperones and Clients., PMID:39222679
The prognostic value of immune escape-related genes in lung adenocarcinoma., PMID:38988926
Recruitment of Ahsa1 to Hsp90 is regulated by a conserved peptide that inhibits ATPase stimulation., PMID:38937628
AHSA1 Regulates Hepatocellular Carcinoma Progression via the TGF-β/Akt-Cyclin D1/CDK6 Pathway., PMID:38022728
Hyperthermia Enhances Adeno-Associated Virus Vector Transduction Efficiency in Melanoma Cells., PMID:37886980
Human Aha1's N-terminal extension confers it holdase activity in vitro., PMID:37486705
Exploration and validation of the prognostic value of RNA-binding proteins in hepatocellular carcinoma., PMID:36524514
p23 and Aha1: Distinct Functions Promote Client Maturation., PMID:36520307
AHSA1 Promotes Proliferation and EMT by Regulating ERK/CALD1 Axis in Hepatocellular Carcinoma., PMID:36230524
The Prognostic and Immunotherapeutic Significance of AHSA1 in Pan-Cancer, and Its Relationship With the Proliferation and Metastasis of Hepatocellular Carcinoma., PMID:35757728
Comprehensive proteomic analysis to elucidate the anti-heat stress effects of nano-selenium in rainbow trout (Oncorhynchus mykiss)., PMID:35689887
Study on the Mechanism of Astragalus Polysaccharide in Treating Pulmonary Fibrosis Based on "Drug-Target-Pathway" Network., PMID:35370663
Identification of AHSA1 as a Potential Therapeutic Target for Breast Cancer: Bioinformatics Analysis and in vitro Studies., PMID:35034596
AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma., PMID:34991674
The Human Hippocampus in Parkinson's Disease: An Integrative Stereological and Proteomic Study., PMID:34092653
Regulation of ClC-2 Chloride Channel Proteostasis by Molecular Chaperones: Correction of Leukodystrophy-Associated Defect., PMID:34070744
Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice., PMID:33832539
Aha1 Exhibits Distinctive Dynamics Behavior and Chaperone-Like Activity., PMID:33808352
Human Primary Airway Basal Cells Display a Continuum of Molecular Phases from Health to Disease in Chronic Obstructive Pulmonary Disease., PMID:33789072
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma., PMID:33571422
AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma., PMID:33468990
Nanobody-siRNA Conjugates for Targeted Delivery of siRNA to Cancer Cells., PMID:33444501
An Integrated Model Based on a Six-Gene Signature Predicts Overall Survival in Patients With Hepatocellular Carcinoma., PMID:32010188
Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis., PMID:31412254
Dynamic Aha1 co-chaperone binding to human Hsp90., PMID:31299134
Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1., PMID:31189925
Solution NMR structure of CHU_1110 from Cytophaga hutchinsonii, an AHSA1 protein potentially involved in metal ion stress response., PMID:30368907
Proteomic Investigation to Identify Anticancer Targets of Nemopilema nomurai Jellyfish Venom in Human Hepatocarcinoma HepG2 Cells., PMID:29748501
microRNA-338-3p inhibits proliferation, migration, invasion, and EMT in osteosarcoma cells by targeting activator of 90 kDa heat shock protein ATPase homolog 1., PMID:29618948
Chemical shift assignments of CHU_1110: an AHSA1-like protein from Cytophaga hutchinsonii., PMID:29318533
Hsp90 activator Aha1 drives production of pathological tau aggregates., PMID:28827321
The flavonoid TL-2-8 induces cell death and immature mitophagy in breast cancer cells via abrogating the function of the AHA1/Hsp90 complex., PMID:28504248
Solution NMR structure of RHE_CH02687 from Rhizobium etli: A novel flavonoid-binding protein., PMID:28160315
Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β., PMID:27580824
Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells., PMID:27467582
Tumor Selective Silencing Using an RNAi-Conjugated Polymeric Nanopharmaceutical., PMID:26835715
AHSA1 regulates proliferation, apoptosis, migration, and invasion of osteosarcoma., PMID:26796264
c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells., PMID:26235616
Treatment of textile wastewater by submerged membrane bioreactor: In vitro bioassays for the assessment of stress response elicited by raw and reclaimed wastewater., PMID:26108634
Hsp90 Oligomers Interacting with the Aha1 Cochaperone: An Outlook for the Hsp90 Chaperone Machineries., PMID:26076190
Detection of gene annotations and protein-protein interaction associated disorders through transitive relationships between integrated annotations., PMID:26046679
Identification of proteins associated with Aha1 in HeLa cells by quantitative proteomics., PMID:25614414
p23 and Aha1., PMID:25487019
Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast., PMID:25486457
Hsp90 C-terminal inhibitors exhibit antimigratory activity by disrupting the Hsp90α/Aha1 complex in PC3-MM2 cells., PMID:25402753
Aha1 can act as an autonomous chaperone to prevent aggregation of stressed proteins., PMID:25378400
For research use only. Not for human or drug use.
