Catalog No.
YHB64001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser481-Asp600
Predicted molecular weight
15.75 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95402
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mediator of RNA polymerase II transcription subunit 26, Activator-recruited cofactor 70 kDa component, ARC70, Cofactor required for Sp1 transcriptional activation subunit 7, CRSP complex subunit 7, Mediator complex subunit 26, Transcriptional coactivator CRSP70, MED26, ARC70, CRSP7
Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module., PMID:39321804
3D chromatin architecture, BRD4, and Mediator have distinct roles in regulating genome-wide transcriptional bursting and gene network., PMID:39121214
An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II., PMID:38955181
Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome., PMID:38898526
Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome., PMID:38293010
MED26-containing Mediator may orchestrate multiple transcription processes through organization of nuclear bodies., PMID:36852638
Signal-induced enhancer activation requires Ku70 to read topoisomerase1-DNA covalent complexes., PMID:36747093
Structures of +1 nucleosome-bound PIC-Mediator complex., PMID:36201575
Identification of Therapeutic Targets and Prognostic Biomarkers among Genes from the Mediator Complex Family in the Hepatocellular Carcinoma Tumour-Immune Microenvironment., PMID:35069777
Elongin functions as a loading factor for Mediator at ATF6α-regulated ER stress response genes., PMID:34544872
Comparison of transcriptional initiation by RNA polymerase II across eukaryotic species., PMID:34515029
A simple protocol to purify human TFIID free of the MED26 subunit of mediator complex., PMID:33836240
The role of Mediator and Little Elongation Complex in transcription termination., PMID:32102997
Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins., PMID:32362303
Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7., PMID:28893534
Cbx3 maintains lineage specificity during neural differentiation., PMID:28270516
TBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription., PMID:27564129
Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II., PMID:27353326
1H, 15N and 13C assignments of the N-terminal domain of the Mediator complex subunit MED26., PMID:26861138
MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex., PMID:25575120
Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit., PMID:25383669
Characterization of the influence of mediator complex in HIV-1 transcription., PMID:25100719
The metazoan-specific mediator subunit 26 (Med26) is essential for viability and is found at both active genes and pericentric heterochromatin in Drosophila melanogaster., PMID:24820420
Regulation of MYC expression and differential JQ1 sensitivity in cancer cells., PMID:24466310
Temporal association of herpes simplex virus ICP4 with cellular complexes functioning at multiple steps in PolII transcription., PMID:24147125
Adenovirus L-E1A activates transcription through mediator complex-dependent recruitment of the super elongation complex., PMID:23302885
[Role for the human mediator subunit Med26 in transcription elongation]., PMID:22991831
The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot (Arabidopsis) and a monocot (rice) during reproduction and abiotic stress., PMID:22021418
Human mediator subunit MED26 functions as a docking site for transcription elongation factors., PMID:21729782
The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26., PMID:21057455
Characterization of transcription from TATA-less promoters: identification of a new core promoter element XCPE2 and analysis of factor requirements., PMID:19337366
MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression., PMID:19049968
Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors., PMID:17138671
A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology., PMID:15175163
Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation., PMID:12050112
Structure of a conserved domain common to the transcription factors TFIIS, elongin A, and CRSP70., PMID:10811649
The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1., PMID:9989412
For research use only. Not for human or drug use.
