Catalog No.
YHB63401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu27-Leu438
Predicted molecular weight
50.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95395
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3, 2.4.1.102, 2.4.1.148, 2.4.1.150, C2GnT-mucin type, C2GnT-M, hC2GnT-M, Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase, C2/4GnT, GCNT3
Clinical efficacy and chemoresistance analysis of precision neoadjuvant chemotherapy for borderline resectable pancreatic cancer: a prospective, single-arm pilot study., PMID:40146255
Comprehensive analysis of eccDNA characteristics and associated genes expression in peripheral blood of ASLE and ISLE patients., PMID:40108975
Depletion of β1,6-N-acetylglucosaminyltransferase reduces E-selectin binding capacity and migratory potential of human gastrointestinal adenocarcinoma cells., PMID:39547084
GCNT3 Promotes Hepatocellular Carcinoma Progression and EMT by Activating the PI3K/AKT Pathway., PMID:38789846
Study on the regulatory mechanism of latent membrane protein 2A on GCNT3 expression in nasopharyngeal carcinoma., PMID:38739247
GCNT3 regulated MUC13 to promote the development of hepatocellular carcinoma through the GSK3β/β-catenin pathway., PMID:38369410
TRANSCRIPTOME ANALYSIS REVEALED THE MOLECULAR SIGNATURES OF CISPLATIN-FLUOROURACIL COMBINED CHEMOTHERAPY RESISTANCE IN GASTRIC CANCER., PMID:38325291
Talniflumate abrogates mucin immune suppressive barrier improving efficacy of gemcitabine and nab-paclitaxel treatment in pancreatic cancer., PMID:37996891
Alterations in ileal transcriptomics during an intestinal barrier challenge in lactating Holstein cows fed a Saccharomyces cerevisiae fermentation product identify potential regulatory processes., PMID:37616596
Effects of soluble glucomannan and insoluble cellulose treatment on mucin secretion and mucin glycosylation-related gene expression in the colons of mice., PMID:37440706
Radiotherapy prognosis-associated gene GCNT3 promotes the proliferation, migration and invasion of lung adenocarcinoma cells., PMID:36578381
Glycosylated modification of MUC1 maybe a new target to promote drug sensitivity and efficacy for breast cancer chemotherapy., PMID:35970845
LINC00511 enhances LUAD malignancy by upregulating GCNT3 via miR-195-5p., PMID:35399076
Molecular docking of two cytotoxic compounds from Calotropis gigantea leaves against therapeutic molecular target of pancreatic cancer., PMID:38449465
Epstein-Barr Virus-Encoded Latent Membrane Protein 2A Downregulates GCNT3 via the TGF-β1/Smad-mTORC1 Signaling Axis., PMID:33658337
Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice., PMID:33465144
Gene Expression Analysis by Real-Time PCR in Nasal Brushings of Adult Patients with Allergic Rhinitis, Suspected Allergic Rhinitis, and Nonallergic Rhinitis., PMID:33171477
Global analysis of human glycosyltransferases reveals novel targets for pancreatic cancer pathogenesis., PMID:32203219
MiR-BART1-5p targets core 2β-1,6-acetylglucosaminyltransferase GCNT3 to inhibit cell proliferation and migration in EBV-associated gastric cancer., PMID:32056716
Downregulation of N-Acetylglucosaminyltransferase GCNT3 by miR-302b-3p Decreases Non-Small Cell Lung Cancer (NSCLC) Cell Proliferation, Migration and Invasion., PMID:30355927
The role of glycosyltransferase enzyme GCNT3 in colon and ovarian cancer prognosis and chemoresistance., PMID:29855486
β-1,3-Galactosyl-O-Glycosyl-Glycoprotein β-1,6-N-Acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility., PMID:28923134
Molecular Pathways: Mucins and Drug Delivery in Cancer., PMID:28039261
Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice., PMID:27143302
Small-Molecule Inhibition of GCNT3 Disrupts Mucin Biosynthesis and Malignant Cellular Behaviors in Pancreatic Cancer., PMID:26880801
Prediction of response to preoperative chemoradiotherapy and establishment of individualized therapy in advanced rectal cancer., PMID:26260776
Core 2 Mucin-Type O-Glycan Is Related to EPEC and EHEC O157:H7 Adherence to Human Colon Carcinoma HT-29 Epithelial Cells., PMID:25701318
Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche., PMID:25421439
The transcriptional profiling of glycogenes associated with hepatocellular carcinoma metastasis., PMID:25232831
Restoration of compact Golgi morphology in advanced prostate cancer enhances susceptibility to galectin-1-induced apoptosis by modifying mucin O-glycan synthesis., PMID:25086069
Determination of carbohydrate structure recognized by prostate-specific F77 monoclonal antibody through expression analysis of glycosyltransferase genes., PMID:24753248
Spdef null mice lack conjunctival goblet cells and provide a model of dry eye., PMID:23665202
Requirement for core 2 O-glycans for optimal resistance to helminth infection., PMID:23555902
A non-enzymatic function of Golgi glycosyltransferases: mediation of Golgi fragmentation by interaction with non-muscle myosin IIA., PMID:23396488
Glycosyltransferase-specific Golgi-targeting mechanisms., PMID:22988244
Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2., PMID:22581805
Infection with the gastrointestinal nematode Ostertagia ostertagi in cattle affects mucus biosynthesis in the abomasum., PMID:21569362
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production., PMID:19759516
Identification of AhR-regulated genes involved in PAH-induced immunotoxicity using a highly-sensitive DNA chip, 3D-Gene Human Immunity and Metabolic Syndrome 9k., PMID:19737606
Mucin biosynthesis in the bovine goblet cell induced by Cooperia oncophora infection., PMID:19647371
Glycosyltransferase function in core 2-type protein O glycosylation., PMID:19349303
Mucin biosynthesis: molecular cloning and expression of mouse mucus-type core 2 beta1,6 N-acetylglucosaminyltransferase., PMID:17591617
Mucin biosynthesis: identification of the cis-regulatory elements of human C2GnT-M gene., PMID:17303715
C2GnT-M is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells., PMID:16418723
Identification of disulfide bonds among the nine core 2 N-acetylglucosaminyltransferase-M cysteines conserved in the mucin beta6-N-acetylglucosaminyltransferase family., PMID:15226299
Lipopolysaccharide Induces Mucus Cell Metaplasia in Mouse Lung., PMID:11152652
Mucin-type O-glycans and leukosialin., PMID:10571013
Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches., PMID:9915862
For research use only. Not for human or drug use.
