Catalog No.
YHB63101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met28-Tyr173
Predicted molecular weight
19.37 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95391
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pre-mRNA-splicing factor SLU7, hSlu7, SLU7
Detection of Nuclear RNA Decay Intermediates Using a Modified Oxford Nanopore RNA Sequencing Strategy., PMID:39535719
Caspases compromise SLU7 and UPF1 stability and NMD activity during hepatocarcinogenesis., PMID:39105183
Cryptococcus neoformans Slu7 ensures nuclear positioning during mitotic progression through RNA splicing., PMID:38768219
Lactylome analyses suggest systematic lysine-lactylated substrates in oral squamous cell carcinoma under normoxia and hypoxia., PMID:38750680
SARS-CoV-2 NSP12 utilizes various host splicing factors for replication and splicing regulation., PMID:38235848
G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC-I via PI3K/Akt Activation in Bladder Cancer., PMID:38084438
A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer., PMID:37408008
SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease., PMID:36362191
Mechanism of exon ligation by human spliceosome., PMID:35705093
The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation., PMID:34331453
Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage., PMID:34170569
Structural basis for conformational equilibrium of the catalytic spliceosome., PMID:33705709
A rapid RNA extraction method from oil palm tissues suitable for reverse transcription quantitative real-time PCR (RT-qPCR)., PMID:33214977
Proteomic Characterization of Proliferation Inhibition of Well-Differentiated Laryngeal Squamous Cell Carcinoma Cells Under Below-Background Radiation in a Deep Underground Environment., PMID:33194991
Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins., PMID:30657957
Dynamic protein-RNA interactions in mediating splicing catalysis., PMID:30395327
Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice., PMID:29870742
An Atomic Structure of the Human Spliceosome., PMID:28502770
Structure of a spliceosome remodelled for exon ligation., PMID:28076345
A central role of Cwc25 in spliceosome dynamics during the catalytic phase of pre-mRNA splicing., PMID:28057857
Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression., PMID:26804174
Splicing regulator SLU7 is essential for maintaining liver homeostasis., PMID:24865429
Stress susceptibility-specific phenotype associated with different hippocampal transcriptomic responses to chronic tricyclic antidepressant treatment in mice., PMID:24225037
Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly., PMID:23754748
Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system., PMID:23685439
Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system., PMID:23431055
Link of NTR-mediated spliceosome disassembly with DEAH-box ATPases Prp2, Prp16, and Prp22., PMID:23166295
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study., PMID:22464253
Dynamic protein-protein interaction wiring of the human spliceosome., PMID:22365833
Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7., PMID:21122810
DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps., PMID:21098140
Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components., PMID:19935684
Amphiregulin induces the alternative splicing of p73 into its oncogenic isoform DeltaEx2p73 in human hepatocellular tumors., PMID:19664633
Prp45 affects Prp22 partition in spliceosomal complexes and splicing efficiency of non-consensus substrates., PMID:19016306
Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing., PMID:17804646
Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing., PMID:17626844
Immunoprecipitation of spliceosomal RNAs by antisera to galectin-1 and galectin-3., PMID:16998182
Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing., PMID:15728250
Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus., PMID:15181151
Boric acid reversibly inhibits the second step of pre-mRNA splicing., PMID:14527690
The birth of an alternatively spliced exon: 3' splice-site selection in Alu exons., PMID:12764196
Dependence of pre-mRNA introns on PRP17, a non-essential splicing factor: implications for efficient progression through cell cycle transitions., PMID:12711678
Mutational analysis identifies two separable roles of the Saccharomyces cerevisiae splicing factor Prp18., PMID:12403466
How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing., PMID:12212850
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis., PMID:11991638
Splicing factor slt11p and its involvement in formation of U2/U6 helix II in activation of the yeast spliceosome., PMID:11158289
Crystal structure of the functional domain of the splicing factor Prp18., PMID:10737784
The RNA splicing factor hSlu7 is required for correct 3' splice-site choice., PMID:10647016
Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing., PMID:10197984
Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing., PMID:9524131
For research use only. Not for human or drug use.
