Catalog No.
YHB52401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp309-Lys426
Predicted molecular weight
15.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95069
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Potassium channel subfamily K member 2, Outward rectifying potassium channel protein TREK-1, TREK-1 K(+) channel subunit, Two pore domain potassium channel TREK-1, Two pore potassium channel TPKC1, KCNK2, TREK, TREK1
The research progress into cellular mechanosensitive ion channels mediating cancer pain., PMID:40515752
LPS2336, a New TREK-1 Channel Activator Identified by High Throughput Screening., PMID:40427633
Thermosensitivity of TREK K2P channels is controlled by a PKA switch and depends on the microtubular network., PMID:40372488
Novel function of TREK-1 in regulating adipocyte differentiation and lipid accumulation., PMID:40057491
Discovery of Isobenzofuran-1(3H)-one Derivatives as Selective TREK-1 Inhibitors with In Vitro and In Vivo Neuroprotective Effects., PMID:40040241
Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound., PMID:39981749
[Research advances on the structure, function, and related diseases of TREK-1 potassium channels]., PMID:39780579
Astrocytic NHERF-1 Increases Seizure Susceptibility by Inhibiting Surface Expression of TREK-1., PMID:39543986
Effect of two activators on the gating of a K2P channel., PMID:39161093
Tick-Derived Peptide Blocks Potassium Channel TREK-1., PMID:39125945
An evolutionarily conserved AnkyrinG-dependent motif clusters axonal K2P K+ channels., PMID:39078369
Osmotically Sensitive TREK Channels in Rat Articular Chondrocytes: Expression and Functional Role., PMID:39063089
Piezo1 ion channels are capable of conformational signaling., PMID:39043183
TREK-1 channel as a therapeutic target for dexmedetomidine-mediated neuroprotection in cerebral ischemia., PMID:38976083
Activation of hTREK-1 by polyunsaturated fatty acids involves direct interaction., PMID:38956407
Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses., PMID:38864289
The TREK-1 potassium channel is involved in both the analgesic and anti-proliferative effects of riluzole in bone cancer pain., PMID:38852511
Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels., PMID:38821927
The TREK-1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension., PMID:38807478
The Inhibition of TREK-1 K+ Channels via Multiple Compounds Contained in the Six Kamikihito Components, Potentially Stimulating Oxytocin Neuron Pathways., PMID:38732124
Sortilin-Mediated Inhibition of TREK1/2 Channels in Primary Sensory Neurons Promotes Prediabetic Neuropathic Pain., PMID:38626370
Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2., PMID:38605031
Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age., PMID:38601986
Myometrium infection decreases TREK1 through NHE1 and increases contraction in pregnant mice., PMID:38344766
Two-pore potassium channel TREK-1 (K2P2.1) regulates NLRP3 inflammasome activity in macrophages., PMID:38252657
TREK-1 inhibition promotes synaptic plasticity in the prelimbic cortex., PMID:38103709
Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants., PMID:37454597
Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1., PMID:37184053
TREK-1 and TREK-2 Knockout Mice Are Not Resistant to Halothane or Isoflurane., PMID:37027798
miR-132-3p promotes heat stimulation-induced esophageal squamous cell carcinoma tumorigenesis by targeting KCNK2., PMID:37014157
High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy., PMID:36909311
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals., PMID:36859433
Blocking Two-Pore Domain Potassium Channel TREK-1 Inhibits the Activation of A1-Like Reactive Astrocyte Through the NF-κB Signaling Pathway in a Rat Model of Major Depressive Disorder., PMID:36670238
Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier., PMID:36650581
Activation of TREK-1 (K2P2.1) potassium channels protects against influenza A-induced lung injury., PMID:36410022
β-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes., PMID:36291187
Ameliorated Neurogenesis Deficits in Dentate Gyrus May Underly the Pronounced Antidepressant Effect of TREK-1 Potassium Channel Blockade in Rats with Depressive-like Behavior., PMID:36269040
Activation of the TREK-1 Potassium Channel Improved Cognitive Deficits in a Mouse Model of Alzheimer's Disease by Modulating Glutamate Metabolism., PMID:35678977
Transition between conformational states of the TREK-1 K2P channel promoted by interaction with PIP2., PMID:35596528
Involvement of TREK1 channels in the proliferation of human hepatic stellate LX-2 cells., PMID:35177207
The Two-Pore Domain Potassium Channel TREK-1 Promotes Blood-Brain Barrier Breakdown and Exacerbates Neuronal Death After Focal Cerebral Ischemia in Mice., PMID:35067892
'C-type' closed state and gating mechanisms of K2P channels revealed by conformational changes of the TREK-1 channel., PMID:35022758
Mini-Review: Two Brothers in Crime - The Interplay of TRESK and TREK in Human Diseases., PMID:34852287
Piezo1 and Piezo2 foster mechanical gating of K2P channels., PMID:34852225
Controlled Decompression Attenuates Compressive Injury following Traumatic Brain Injury via TREK-1-Mediated Inhibition of Necroptosis and Neuroinflammation., PMID:34790287
Effect of menstrual cycle and female hormones on TRP and TREK channels in modifying thermosensitivity and physiological functions in women., PMID:34503776
Engineering 2D approaches fibrous platform incorporating turmeric and polyaniline nanoparticles to predict the expression of βIII-Tubulin and TREK-1 through qRT-PCR to detect neuronal differentiation of PC12 cells., PMID:34225892
TREK-1 potassium channels participate in acute and long-lasting nociceptive hypersensitivity induced by formalin in rats., PMID:34224765
Multifaceted Regulation of Potassium-Ion Channels by Graphene Quantum Dots., PMID:34126740
Production of K2P2.1 (TREK-1) for structural studies., PMID:34099170
For research use only. Not for human or drug use.
