Catalog No.
YHB50201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser275-Ser405
Predicted molecular weight
17.44 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O94972
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E3 ubiquitin-protein ligase TRIM37, 2.3.2.27, Mulibrey nanism protein, RING-type E3 ubiquitin transferase TRIM37, Tripartite motif-containing protein 37, TRIM37, KIAA0898, MUL, POB1
TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization., PMID:40415024
Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37., PMID:40415023
Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor., PMID:40378279
TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer., PMID:40223081
Activation of TRIM37 by ATF6 and degradation of ACSL4: inhibiting ferroptosis and propelling cervical cancer progression., PMID:40158112
TRIM37 exacerbates cerebral ischemic injury by regulating the PPARγ/NF-κB pathway., PMID:39661528
The TRIM37 variant rs57141087 contributes to triple-negative breast cancer outcomes in Black women., PMID:39614126
Skeletal Phenotype in Mulibrey Nanism, A Monogenic Skeletal Dysplasia With Fibrous Dysplasia., PMID:39558672
Mesoscale regulation of MTOCs by the E3 ligase TRIM37., PMID:39416078
TRIM37 employs peptide motif recognition and substrate-dependent oligomerization to prevent ectopic spindle pole assembly., PMID:39416052
N6-methyladenosine-modified TRIM37 augments sunitinib resistance by promoting the ubiquitin-degradation of SmARCC2 and activating the Wnt signaling pathway in renal cell carcinoma., PMID:39349442
KIFC1 depends on TRIM37-mediated ubiquitination of PLK4 to promote centrosome amplification in endometrial cancer., PMID:39349439
Nanobubble-mediated co-delivery of siTRIM37 and IR780 for gene and sonodynamic combination therapy against triple negative breast cancer., PMID:39312939
TME-Responsive Nanoplatform with Glutathione Depletion for Enhanced Tumor-Specific Mild Photothermal/Gene/Ferroptosis Synergistic Therapy., PMID:39258005
Molecular similarities between the genes for Trypanosoma cruzi microtubule-associated proteins, mammalian interferons, and TRIMs., PMID:39251458
Mulibrey Nanism: A Case with Heart Failure., PMID:39225643
A proteomic study of the downregulation of TRIM37 on chondrocytes: Implications for the MULIBREY syndrome., PMID:39019132
TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and regulate stemness in glioma stem cells through sonic hedgehog pathway., PMID:38884661
LncRNA HOXC-AS3 accelerates malignant proliferation of cervical cancer cells via stabilizing KDM5B., PMID:38842683
TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington's disease., PMID:38758800
TRIM27 Promotes Endothelial Progenitor Cell Apoptosis in Patients with In-Stent Restenosis by Ubiquitinating TBK1., PMID:38558276
Mulibrey nanism and immunological complications: a comprehensive case report and literature review., PMID:38116000
The role of hepatitis B virus surface protein in inducing Sertoli cell ferroptosis., PMID:37644905
Molecular characterization and functional analysis of TRIM37 from black tiger shrimp (Penaeus monodon)., PMID:37442309
A multi-platform normalization method for meta-analysis of gene expression data., PMID:37423473
Mechanisms of insertions at a DNA double-strand break., PMID:37402370
Discovery of the First Potent, Selective, and In Vivo Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of TRIM37-Amplified Breast Cancer., PMID:37279162
TRIM37 exacerbates hepatic ischemia/reperfusion injury by facilitating IKKγ translocation., PMID:37158850
Downregulation of BASP1 Promotes Temozolomide Resistance in Gliomas via Epigenetic Activation of the FBXO32/NF-κB/MGMT Axis., PMID:36961398
Identifying genetic variants regulating MGMT gene expression - A study in monozygotic Danish twins., PMID:36948276
Whole Exome Sequencing Identified the Causative Mutation in a 4-Year-Old Female with Mulibrey Nanism: A Case Report., PMID:36742244
Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37., PMID:36252649
lncRNA NUTM2A-AS1 Targets the SRSF1/Trim37 Signaling Pathway to Promote the Proliferation and Invasion of Breast Cancer., PMID:35959349
Metformin inhibits the proliferation and invasion of ovarian cancer cells by suppressing tripartite motif-containing 37-induced tumor necrosis factor receptor-associated factor 2 ubiquitination., PMID:35950370
TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1., PMID:35921902
TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression., PMID:35864973
PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer., PMID:35859118
Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number., PMID:35758262
Design, synthesis, and biological evaluation of novel pyrazolo [3,4-d]pyrimidine derivatives as potent PLK4 inhibitors for the treatment of TRIM37-amplified breast cancer., PMID:35576702
Mechanism of RNA-binding protein Lin28 in neuronal ferroptosis after intracerebral haemorrhage., PMID:35359144
Modified Yuejuwan Inhibited Cholesterol Accumulation and Inflammation in THP-1 Macrophage-Derived Foam Cells by Inhibiting the Activity of the TRIM37/TRAF2/NF-κB Pathway., PMID:35310029
Liver pathology and biochemistry in patients with mutations in TRIM37 gene (Mulibrey nanism)., PMID:35220664
Identification Prognostic Value and Correlation with Tumor-Infiltrating Immune Cells of Tripartite-Motif Family Genes in Hepatocellular Carcinoma., PMID:35173473
TRIM37 Promotes Pancreatic Cancer Progression through Modulation of Cell Growth, Migration, Invasion, and Tumor Immune Microenvironment., PMID:35163097
Comprehensive profiling of the TRIpartite motif family to identify pivot genes in hepatocellular carcinoma., PMID:35142083
The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments., PMID:34982428
miR-942-5p prevents sepsis-induced acute lung injury via targeting TRIM37., PMID:34716956
TRIM37: a critical orchestrator of centrosome function., PMID:34672905
Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis., PMID:34524943
Variants in 46,XY DSD-Related Genes in Syndromic and Non-Syndromic Small for Gestational Age Children with Hypospadias., PMID:34518484
For research use only. Not for human or drug use.
