Catalog No.
YHB48901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser176-Asn617
Predicted molecular weight
52.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O94923
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
D-glucuronyl C5-epimerase, 5.1.3.17, Heparan sulfate C5-epimerase, Hsepi, Heparin/heparan sulfate:glucuronic acid C5-epimerase, Heparosan-N-sulfate-glucuronate 5-epimerase, GLCE, KIAA0836
Cell-surface d-glucuronyl C5-epimerase binds to porcine deltacoronavirus spike protein facilitating viral entry., PMID:39078176
Validation of Candidate Host Cell Entry Factors for Bovine Herpes Virus Type-1 Based on a Genome-Wide CRISPR Knockout Screen., PMID:38400072
Identifying genes for regulating osteogenic differentiation of human periodontal ligament stem cells in inflammatory environments by bioinformatics analysis., PMID:38082497
Relationship between rate of glucose or propionate infusion and milk protein yield and concentration in dairy cows: A meta-regression., PMID:37806622
External validation of genetically predicted protein biomarkers for pancreatic cancer risk using aptamer-based plasma levels: A prospective analysis in the Atherosclerosis Risk in Communities Study., PMID:37338014
Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15., PMID:37217020
FAIM2 is correlated with metastasis of medulloblastoma through bioinformatics analysis., PMID:37083768
Identification of candidate genomic regions for egg yolk moisture content based on a genome-wide association study., PMID:36918797
An improved Fuzzy based GWO algorithm for predicting the potential host receptor of COVID-19 infection., PMID:36334362
Glycolysis- and immune-related novel prognostic biomarkers of Ewing's sarcoma: glucuronic acid epimerase and triosephosphate isomerase 1., PMID:34233293
[Expression optimization and molecular modification of heparin C5 epimerase]., PMID:32748603
Glucuronyl C5-epimerase is crucial for epithelial cell maturation during embryonic lung development., PMID:32651954
Transcriptome analysis and identification of genes associated with chicken sperm storage duration., PMID:32036969
Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy., PMID:31834878
The genetic mechanism of high prolificacy in small tail han sheep by comparative proteomics of ovaries in the follicular and luteal stages., PMID:31146049
Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase., PMID:30872481
Heparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic Cartilage., PMID:30553836
Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells., PMID:30458230
Effect of Polarization and Chronic Inflammation on Macrophage Expression of Heparan Sulfate Proteoglycans and Biosynthesis Enzymes., PMID:30205019
Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation., PMID:29104277
GLCE rs3865014 (Val597Ile) polymorphism is associated with breast cancer susceptibility and triple-negative breast cancer in Siberian population., PMID:28734894
Transposon Mutagenesis Identifies Genes Critical for Growth of Pseudomonas nitroreducens TX1 on Octylphenol Polyethoxylates., PMID:27590807
Glucuronic Acid Epimerase (GLCE) Variant rs3865014 (A>G) Is Associated with BMI, Blood Hemoglobin, Hypertension, and Cerebrovascular Events, the TAMRISK Study., PMID:27699767
Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis., PMID:27511124
Proteoglycan expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines., PMID:26527314
Tissue-specificity of heparan sulfate biosynthetic machinery in cancer., PMID:26120938
Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones., PMID:26116392
Structural and functional study of D-glucuronyl C5-epimerase., PMID:25568314
GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling., PMID:24499487
Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome., PMID:24467795
Heterogeneity of d-glucuronyl C5-epimerase expression and epigenetic regulation in prostate cancer., PMID:24403231
D-glucuronyl C5-epimerase cell type specifically affects angiogenesis pathway in different prostate cancer cells., PMID:24264315
miRNA-218 contributes to the regulation of D-glucuronyl C5-epimerase expression in normal and tumor breast tissues., PMID:22968430
The TCF4/β-catenin pathway and chromatin structure cooperate to regulate D-glucuronyl C5-epimerase expression in breast cancer., PMID:22805760
Glucuronic acid epimerase is associated with plasma triglyceride and high-density lipoprotein cholesterol levels in Turks., PMID:21488854
Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival., PMID:21471524
MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling., PMID:20947829
Glucuronyl C5-epimerase an enzyme converting glucuronic acid to iduronic acid in heparan sulfate/heparin biosynthesis., PMID:20807641
Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase., PMID:20208005
Hydrogen peroxide as a potential mediator of the transcriptional regulation of heparan sulphate biosynthesis in keratinocytes., PMID:18463796
Decreased expression of human D-glucuronyl C5-epimerase in breast cancer., PMID:17985344
D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish., PMID:16156897
The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway., PMID:15853773
glc locus of Escherichia coli: characterization of genes encoding the subunits of glycolate oxidase and the glc regulator protein., PMID:8606183
For research use only. Not for human or drug use.
