Catalog No.
YHB48201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly142-Gly397
Predicted molecular weight
31.77 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O94910
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Adhesion G protein-coupled receptor L1, Calcium-independent alpha-latrotoxin receptor 1, CIRL-1, Latrophilin-1, Lectomedin-2, ADGRL1, KIAA0821, LEC2, LPHN1
Genome-Wide Identification and Expression Analysis of Zona Pellucida (ZP) Gene Family in Cynoglossus semilaevis., PMID:40508155
Signaling by latrophilin adhesion-GPCRs in synapse assembly., PMID:40127755
α-Latrotoxin Actions in the Absence of Extracellular Ca2+ Require Release of Stored Ca2., PMID:39998090
Adhesion G protein-coupled receptor latrophilin 1 (ADGRL1): a novel regulator of glucose and energy homeostasis., PMID:39080020
ADGRL1 variants: From developmental and epileptic encephalopathy to genetic epilepsy with febrile seizures plus., PMID:38927006
A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets for breast cancer., PMID:38834774
Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development., PMID:38713721
Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses., PMID:38684366
Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity., PMID:38664368
Stimulating T cell responses against patient-derived breast cancer cells with neoantigen peptide-loaded peripheral blood mononuclear cells., PMID:38349410
Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway., PMID:37944639
Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs., PMID:37831892
ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis., PMID:37712955
Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder., PMID:36746957
GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons., PMID:36453010
ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model., PMID:35907405
A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets in Uterine Corpus Endometrial cancer., PMID:35413679
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain., PMID:33497605
Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination., PMID:32996461
C-terminal phosphorylation of latrophilin-1/ADGRL1 affects the interaction between its fragments., PMID:31553068
Alternative splicing event modifying ADGRL1/latrophilin-1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways., PMID:31339586
Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones., PMID:30457553
A Comprehensive Mutagenesis Screen of the Adhesion GPCR Latrophilin-1/ADGRL1., PMID:30428326
Lect2 Controls Inflammatory Monocytes to Constrain the Growth and Progression of Hepatocellular Carcinoma., PMID:30070727
Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1., PMID:29938681
Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression., PMID:29907881
Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse., PMID:29677516
Role of sialic acid-containing glycans of matrix metalloproteinase-9 (MMP-9) in the interaction between MMP-9 and staphylococcal superantigen-like protein 5., PMID:29328525
The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells., PMID:28750861
Latrophilin receptors: novel bronchodilator targets in asthma., PMID:27325752
Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells., PMID:27322212
Super-complexes of adhesion GPCRs and neural guidance receptors., PMID:27091502
Role of the teneurins, teneurin C-terminal associated peptides (TCAP) in reproduction: clinical perspectives., PMID:26485751
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors., PMID:25713288
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis., PMID:22333914
High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex., PMID:22262843
Association of the subunits of the calcium-independent receptor of α-latrotoxin., PMID:20971062
Regulation of CIRL-1 proteolysis and trafficking., PMID:20100540
Latrophilin signalling in tissue polarity and morphogenesis., PMID:21618824
Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain., PMID:18547526
Interaction of calcium-independent latrotoxin receptor with intracellular adapter protein TRIP8b., PMID:17695324
Post-translational proteolytic processing of the calcium-independent receptor of alpha-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor. Role of the G protein-coupled receptor proteolysis site (GPS) motif., PMID:12270923
Involvement of the calcium-independent receptor for alpha-latrotoxin in brain ischemia., PMID:12225880
Protein-tyrosine phosphatase-sigma is a novel member of the functional family of alpha-latrotoxin receptors., PMID:12110683
For research use only. Not for human or drug use.
