Catalog No.
YHB47501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys497-Ser786
Predicted molecular weight
34.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O94898
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Leucine-rich repeats and immunoglobulin-like domains protein 2, LIG-2, LRIG2, KIAA0806, LIG2
Causal relationship between inflammatory cytokines and posttraumatic stress disorder: a Mendelian randomization study and potential mechanism analysis., PMID:40314372
Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish., PMID:40305763
Urofacial (Ochoa) syndrome with a founder pathogenic variant in the HPSE2 gene: a case report and mutation origin., PMID:39150614
A SINE-VNTR-Alu at the LRIG2 locus is associated with proximal and distal gene expression in CRISPR and population models., PMID:38191889
Ligand-specific regulation of transforming growth factor beta superfamily factors by leucine-rich repeats and immunoglobulin-like domains proteins., PMID:37603563
LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma., PMID:36183058
LRIG2 promotes glioblastoma progression by modulating innate antitumor immunity through macrophage infiltration and polarization., PMID:36096529
HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling?, PMID:35969315
Expanding the HPSE2 Genotypic Spectrum in Urofacial Syndrome, A Disease Featuring a Peripheral Neuropathy of the Urinary Bladder., PMID:35812751
Prognostic significance of LRIG2 and LRIG3 proteins in urothelial bladder carcinoma., PMID:34839782
Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers., PMID:34373746
The Prognostic Role of LRIG Proteins in Endometrial Cancer., PMID:33802837
LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes., PMID:33469151
A SINE-VNTR-Alu in the LRIG2 Promoter Is Associated with Gene Expression at the Locus., PMID:33187279
CircRNA hsa_circRNA_0001776 inhibits proliferation and promotes apoptosis in endometrial cancer via downregulating LRIG2 by sponging miR-182., PMID:32863771
Genomic analyses of early responses to radiation inglioblastoma reveal new alterations at transcription,splicing, and translation levels., PMID:32488114
Targeting LRIG2 overcomes resistance to EGFR inhibitor in glioblastoma by modulating GAS6/AXL/SRC signaling., PMID:31988476
miR-503 Inhibits Proliferation, Migration, And Angiogenesis Of Glioma By Acting On VEGFA Through Targeting LRIG2., PMID:31908532
The transmembrane protein LRIG2 increases tumor progression in skin carcinogenesis., PMID:31580518
LRIG1‑2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: Association with prognosis in relation to HPV‑DNA and p16INK4a status., PMID:31059071
Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder., PMID:30885509
Long non-coding RNA LINC00461/miR-149-5p/LRIG2 axis regulates hepatocellular carcinoma progression., PMID:30879766
LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease., PMID:30429017
LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling., PMID:30015847
Recurrent UTI - Make the Child Smile!, PMID:29503278
LRIG2 is a growth suppressor of Hec-1A and Ishikawa endometrial adenocarcinoma cells by regulating PI3K/AKT- and EGFR-mediated apoptosis and cell-cycle., PMID:29358688
A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors., PMID:29317492
LRIG proteins in glioma: Functional roles, molecular mechanisms, and potential clinical implications., PMID:29246624
Downregulation of LRIG2 expression inhibits angiogenesis of glioma via EGFR/VEGF-A pathway., PMID:28943909
Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma., PMID:28841699
Notch1 targeted regulation of mir-224/LRIG2 signaling for the proliferation and apoptosis of cervical cancer cells., PMID:28454395
Two hits in one: whole genome sequencing unveils LIG4 syndrome and urofacial syndrome in a case report of a child with complex phenotype., PMID:27855655
LRIGs: A Prognostically Significant Family with Emerging Therapeutic Competence against Cancers., PMID:27628597
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases., PMID:26651291
LRIG1 is a prognostic biomarker in non-small cell lung cancer., PMID:25813475
Soluble LRIG2 ectodomain is released from glioblastoma cells and promotes the proliferation and inhibits the apoptosis of glioblastoma cells in vitro and in vivo in a similar manner to the full-length LRIG2., PMID:25353163
Central neurocytoma with ependymoma-like glial component., PMID:25348672
The LRIG family: enigmatic regulators of growth factor receptor signaling., PMID:25183430
LRIG and cancer prognosis., PMID:25180912
Urinary tract effects of HPSE2 mutations., PMID:25145936
LRIG2 expression and prognosis in non-small cell lung cancer., PMID:25013483
Immunohistochemical LRIG3 expression in cervical intraepithelial neoplasia and invasive squamous cell cervical cancer: association with expression of tumor markers, hormones, high-risk HPV-infection, smoking and patient outcome., PMID:24998916
Clinical and genetic characteristics for the Urofacial Syndrome (UFS)., PMID:24966895
Expression of LRIG1 is associated with good prognosis and human papillomavirus status in oropharyngeal cancer., PMID:24548859
In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear., PMID:24086156
Lrig2-deficient mice are protected against PDGFB-induced glioma., PMID:24023893
Urofacial syndrome: a genetic and congenital disease of aberrant urinary bladder innervation., PMID:23832138
Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3)., PMID:23723069
Genetics of human congenital urinary bladder disease., PMID:23584850
For research use only. Not for human or drug use.
