Catalog No.
DHD26501
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Chimeric
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
CD105, END, Endoglin, ENG
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P17813
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
TRC-105, c-SN6j, CAS: 1268714-50-6
Clone ID
Carotuximab
Endoglin: Beyond the Endothelium, PMID: 32059544
Endoglin Targeting: Lessons Learned and Questions That Remain, PMID: 33375670
Endoglin-targeted cancer therapy, PMID: 21034418
An adaptive population enrichment phase III trial of TRC105 and pazopanib versus pazopanib alone in patients with advanced angiosarcoma (TAPPAS trial), PMID: 30357394
Antibodies to watch in 2018, PMID: 29300693
Endoglin for targeted cancer treatment, PMID: 24445497
Clinical Results and Biomarker Analyses of Axitinib and TRC105 versus Axitinib Alone in Patients with Advanced or Metastatic Renal Cell Carcinoma (TRAXAR), PMID: 33829609
Anti-angiogenesis in prostate cancer: knocked down but not out, PMID: 24759579
The Role of Endoglin in Hepatocellular Carcinoma, PMID: 33809908
Antagonizing CD105 enhances radiation sensitivity in prostate cancer, PMID: 29717261
Targeting angiogenesis for radioimmunotherapy with a 177 Lu-labeled antibody, PMID: 28821931
86/90 Y-Based Theranostics Targeting Angiogenesis in a Murine Breast Cancer Model, PMID: 29787283
Novel Preparation Methods of (52)Mn for ImmunoPET Imaging, PMID: 26317429
Targeting Endoglin to Treat Metastatic Renal Cell Carcinoma: Lessons from Osler-Weber-Rendu Syndrome, PMID: 30139834
Red fluorescent zinc oxide nanoparticle: a novel platform for cancer targeting, PMID: 25607242
Anti-CD105 Antibody Eliminates Tumor Microenvironment Cells and Enhances Anti-GD2 Antibody Immunotherapy of Neuroblastoma with Activated Natural Killer Cells, PMID: 31068371
Bevacizumab alone or in combination with TRC105 for patients with refractory metastatic renal cell cancer, PMID: 28832978
In vivo tumor vasculature targeted PET/NIRF imaging with TRC105(Fab)-conjugated, dual-labeled mesoporous silica nanoparticles, PMID: 24937108
Endoglin targeting inhibits tumor angiogenesis and metastatic spread in breast cancer, PMID: 26804178
Effects of the combination of TRC105 and bevacizumab on endothelial cell biology, PMID: 24994097
Modulation of Circulating Protein Biomarkers in Cancer Patients Receiving Bevacizumab and the Anti-Endoglin Antibody, TRC105, PMID: 29997150
Endoglin: a novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models, PMID: 28351936
PET Imaging of Abdominal Aortic Aneurysm with 64Cu-Labeled Anti-CD105 Antibody Fab Fragment, PMID: 25883125
Engineering of hollow mesoporous silica nanoparticles for remarkably enhanced tumor active targeting efficacy, PMID: 24875656
Phase I and Preliminary Phase II Study of TRC105 in Combination with Sorafenib in Hepatocellular Carcinoma, PMID: 28465443
A phase I study of TRC105 anti-endoglin (CD105) antibody in metastatic castration-resistant prostate cancer, PMID: 25407442
A Phase II Clinical Trial of TRC105 (Anti-Endoglin Antibody) in Adults With Advanced/Metastatic Urothelial Carcinoma, PMID: 27328856
Modulation of circulating protein biomarkers following TRC105 (anti-endoglin antibody) treatment in patients with advanced cancer, PMID: 24574330
A phase I first-in-human study of TRC105 (Anti-Endoglin Antibody) in patients with advanced cancer, PMID: 22767667
Positron emission tomography imaging of angiogenesis in a murine hindlimb ischemia model with 64Cu-labeled TRC105, PMID: 23738915
An open-label phase Ib dose-escalation study of TRC105 (anti-endoglin antibody) with bevacizumab in patients with advanced cancer, PMID: 25261556
Imaging tumor angiogenesis in breast cancer experimental lung metastasis with positron emission tomography, near-infrared fluorescence, and bioluminescence, PMID: 23471463
Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling, PMID: 24077288
Durable remission for a woman with refractory choriocarcinoma treated with anti-endoglin monoclonal antibody and bevacizumab: A case from the New England Trophoblastic Disease Center, Brigham and Women's Hospital and Dana-Farber Cancer Institute, PMID: 29217138
High Yield Production and Radiochemical Isolation of Isotopically Pure Arsenic-72 and Novel Radioarsenic Labeling Strategies for the Development of Theranostic Radiopharmaceuticals, PMID: 26646989
For research use only. Not for human or drug use.
