Catalog No.
YHB40601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu339
Predicted molecular weight
39.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O76071
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Probable cytosolic iron-sulfur protein assembly protein CIAO1, WD repeat-containing protein 39, CIAO1, CIA1, WDR39
Mutations in the cytoplasmic iron-sulfur assembly protein CIAO1 cause neuromuscular deficits., PMID:40047889
The critical role of the iron-sulfur cluster and CTC components in DOG-1/BRIP1 function in Caenorhabditis elegans., PMID:39011897
CIAO1 loss of function causes a neuromuscular disorder with compromise of nucleocytoplasmic Fe-S enzymes., PMID:38950322
Iron‑sulfur clusters in viral proteins: Exploring their elusive nature, roles and new avenues for targeting infections., PMID:38599324
CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders., PMID:38411040
Loss of Function of the Cytoplasmic Fe-S Assembly Protein CIAO1 Causes a Neuromuscular Disorder with Compromise of Nucleocytoplasmic Fe-S Enzymes., PMID:38196629
Experimental assessment of robust reference genes for qRT-PCR in lung cancer studies., PMID:37274277
Iron-regulated assembly of the cytosolic iron-sulfur cluster biogenesis machinery., PMID:35654137
A Novel Heterozygous Missense Variant in the CIAO1 Gene in a Family with Alzheimer's Disease: The Val67Ile Variant Promotes the Interaction of CIAO1 and Amyloid-β Protein Precursor., PMID:34569959
Structural insights into Fe-S protein biogenesis by the CIA targeting complex., PMID:32632277
Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila., PMID:32404863
Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis., PMID:32311335
CIAO3 protein forms a stable ternary complex with two key players of the human cytosolic iron-sulfur cluster assembly machinery., PMID:32222833
An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis., PMID:31229404
The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways., PMID:30923992
Investigating the role of the human CIA2A-CIAO1 complex in the maturation of aconitase., PMID:29842905
Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients., PMID:29309586
Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin., PMID:28615450
The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins., PMID:28178521
A Glutaredoxin·BolA Complex Serves as an Iron-Sulfur Cluster Chaperone for the Cytosolic Cluster Assembly Machinery., PMID:27519415
Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19., PMID:27235625
Subcellular RNA profiling links splicing and nuclear DICER1 to alternative cleavage and polyadenylation., PMID:26546131
The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway., PMID:25897079
Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity., PMID:24245804
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins., PMID:23891004
IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway., PMID:23585563
The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly., PMID:23150669
Inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by systems-theoretical analysis., PMID:22955522
The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer., PMID:22683786
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity., PMID:22678362
MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism., PMID:22678361
MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation., PMID:20797633
Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis., PMID:17937914
Affinity purification reveals the association of WD40 protein constitutive photomorphogenic 1 with the hetero-oligomeric TCP-1 chaperonin complex in mammalian cells., PMID:16497536
Structural organization, tissue expression, and chromosomal localization of Ciao 1, a functional modulator of the Wilms' tumor suppressor, WT1., PMID:10438340
Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1., PMID:9556563
For research use only. Not for human or drug use.
