Catalog No.
YHB36501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys96-Pro353
Predicted molecular weight
31.65 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75943
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cell cycle checkpoint protein RAD17, hRad17, RF-C/activator 1 homolog, RAD17, R24L
Neuropilin Antagonists (NRPas) Block the Phosphorylation of the Cancer Therapeutic Key Factor p38α Kinase Triggering Cell Death., PMID:40286084
PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells., PMID:39695328
Separable roles of the DNA damage response kinase Mec1ATR and its activator Rad24RAD17 during meiotic recombination., PMID:39652586
PrimPol-mediated repriming elicits gap-filling by template switching and promotes cellular tolerance to cidofovir., PMID:39577201
RAD18- and BRCA1-dependent pathways promote cellular tolerance to the nucleoside analog ganciclovir., PMID:39169841
Identification of RAD17 as a candidate cancer predisposition gene in families with histories of pancreatic and breast cancers., PMID:38872153
Activating the abscission checkpoint: Top2α senses chromatin bridges in cytokinesis: Top2α binds to DNA knots on chromatin bridges to activate the abscission checkpoint in human cells., PMID:38403725
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp-loader interface., PMID:37713925
Regulation of gene editing using T-DNA concatenation., PMID:37653336
The abscission checkpoint senses chromatin bridges through Top2α recruitment to DNA knots., PMID:37638884
The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO., PMID:36841485
Yeast 9-1-1 complex acts as a sliding clamp for DNA synthesis by DNA polymerase ε., PMID:36410434
Rad17 Translocates to Nucleolus upon UV Irradiation through Nucleolar Localization Signal in the Central Basic Domain., PMID:36293155
ASPM promotes ATR-CHK1 activation and stabilizes stalled replication forks in response to replication stress., PMID:36161901
Dietary Modulation of the Human Gut Microbiota and Metabolome with Flaxseed Preparations., PMID:36142393
Evaluation of natural chronic low dose radiation exposure on telomere length and transcriptional response of shelterin complex in individuals residing in Kerala coast, India., PMID:36116241
Unexpected new insights into DNA clamp loaders: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage., PMID:36116108
Multifunctional mesoporous silica-cerium oxide nanozymes facilitate miR129 delivery for high-quality healing of radiation-induced skin injury., PMID:36104685
Structure of the human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp bound to a dsDNA-ssDNA junction., PMID:35819203
A ferrocene-containing nucleoside analogue targets DNA replication in pancreatic cancer cells., PMID:35689667
Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons., PMID:34746147
The Cell Cycle Checkpoint Gene, RAD17 rs1045051, Is Associated with Prostate Cancer Risk., PMID:34511607
Nuclear translocation promotes proteasomal degradation of human Rad17 protein through the N-terminal destruction boxes., PMID:34174284
Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer., PMID:33949734
Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress., PMID:33820915
Trans-resveratrol imparts disparate effects on transcription of DNA damage sensing/repair pathway genes in euglycemic and hyperglycemic rat testis., PMID:33775663
ZmRAD17 Is Required for Accurate Double-Strand Break Repair During Maize Male Meiosis., PMID:33719299
Eukaryotic clamp loaders and unloaders in the maintenance of genome stability., PMID:33339954
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis., PMID:33013423
IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer., PMID:32896617
Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis., PMID:32702724
Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis., PMID:32587985
SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability., PMID:31867888
The noncoding function of NELFA mRNA promotes the development of oesophageal squamous cell carcinoma by regulating the Rad17-RFC2-5 complex., PMID:31845510
Distinct Functions in Regulation of Meiotic Crossovers for DNA Damage Response Clamp Loader Rad24(Rad17) and Mec1(ATR) Kinase., PMID:31597673
Investigation of the Possible Role of RAD9 in Post-Diapaused Embryonic Development of the Brine Shrimp Artemia sinica., PMID:31574972
The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas., PMID:31514456
Human Rad17 C-terminal tail is phosphorylated by concerted action of CK1δ/ε and CK2 to promote interaction with the 9-1-1 complex., PMID:31353086
Anhydroglucitol-core gallotannins from red maple buds modulate viability of human blood neutrophils., PMID:31100377
OsRAD17 Is Required for Meiotic Double-Strand Break Repair and Plays a Redundant Role With OsZIP4 in Synaptonemal Complex Assembly., PMID:30210516
The RAD17 Promoter Sequence Contains a Potential Tail-Dependent G-Quadruplex That Downregulates Gene Expression upon Oxidative Modification., PMID:30063821
Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites., PMID:30061412
Casein kinase 2 promotes interaction between Rad17 and the 9-1-1 complex through constitutive phosphorylation of the C-terminal tail of human Rad17., PMID:29902452
Unusual Isothermal Hysteresis in DNA i-Motif pH Transitions: A Study of the RAD17 Promoter Sequence., PMID:29694860
ATR kinase regulates its attenuation via PPM1D phosphatase recruitment to chromatin during recovery from DNA replication stress signalling., PMID:29485113
2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study., PMID:29358921
Functions of Multiple Clamp and Clamp-Loader Complexes in Eukaryotic DNA Replication., PMID:29357057
Flip/flop mating-type switching in the methylotrophic yeast Ogataea polymorpha is regulated by an Efg1-Rme1-Ste12 pathway., PMID:29176810
The polyanionic C-terminal tail of human Rad17 regulates interaction with the 9-1-1 complex., PMID:28666868
Systematic Analysis of the DNA Damage Response Network in Telomere Defective Budding Yeast., PMID:28546384
For research use only. Not for human or drug use.
