Catalog No.
YHB35901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu151-Cys425
Predicted molecular weight
33.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75928
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E3 SUMO-protein ligase PIAS2, 2.3.2.-, Androgen receptor-interacting protein 3, ARIP3, DAB2-interacting protein, DIP, E3 SUMO-protein transferase PIAS2, Msx-interacting zinc finger protein, Miz1, PIAS-NY protein, Protein inhibitor of activated STAT x, Protein inhibitor of activated STAT2, PIAS2, PIASX
Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restriction., PMID:39737943
PIAS family gene expression: implications for prognosis, immunomodulation, and chemotherapy response., PMID:39678595
Pharmacologic Induction of ERα SUMOylation Disrupts Its Chromatin Binding., PMID:39432240
Protein inhibitor of activated signal transducer and activator of transcription 2 is an oncoprotein in oral squamous cell carcinoma and related to cigarette smoking - An in vitro study., PMID:39347031
dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe., PMID:38744818
The Identification of Host Proteins That Interact with Non-Structural Proteins-1α and -1β of Porcine Reproductive and Respiratory Syndrome Virus-1., PMID:38140685
SUMO-activated target traps (SATTs) enable the identification of a comprehensive E3-specific SUMO proteome., PMID:37531430
IL-17 promotes melanoma through TRAF2 as a scaffold protein recruiting PIAS2 and ELAVL1 to induce EPHA5., PMID:37481078
Increased Small Ubiquitin-like Modifier-Activating Enzyme SAE1 Promotes Hepatocellular Carcinoma by Enhancing mTOR SUMOylation., PMID:36748193
Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy., PMID:36251411
A genetically linked pair of NLR immune receptors shows contrasting patterns of evolution., PMID:35771942
Curcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis., PMID:35473503
Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxα., PMID:34947973
PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia., PMID:34234281
Expression of PIAS Genes in Migraine Patients., PMID:33763841
Cardiolipin-mediated PPARγ S112 phosphorylation impairs IL-10 production and inflammation resolution during bacterial pneumonia., PMID:33567272
A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease., PMID:33151932
Duck PIAS2 Promotes H5N1 Avian Influenza Virus Replication Through Its SUMO E3 Ligase Activity., PMID:32595623
SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites., PMID:32576812
Characterization of a C-Terminal SUMO-Interacting Motif Present in Select PIAS-Family Proteins., PMID:32348746
SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation., PMID:32249212
Duck PIAS2 negatively regulates RIG-I mediated IFN-β production by interacting with IRF7., PMID:32151676
Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis., PMID:31582715
Protein inhibitor of activated STAT genes are differentially expressed in breast tumor tissues., PMID:31244388
The investigation of relevancy between PIAS1 and PIAS2 gene expression and disease severity of multiple sclerosis., PMID:31084243
T Cell Receptor (TCR)-Induced PLC-γ1 Sumoylation via PIASxβ and PIAS3 SUMO E3 Ligases Regulates the Microcluster Assembly and Physiological Function of PLC-γ1., PMID:30873169
PIAS genes as disease markers in bipolar disorder., PMID:30861611
p38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of Elk-1 activity in heat-stressed HeLa cells., PMID:30783905
Expression analysis of protein inhibitor of activated STAT (PIAS) genes in IFNβ-treated multiple sclerosis patients., PMID:30584347
Pre- and post-puberty expression of genes and proteins in the uterus of Bos indicus heifers: the luteal phase effect post-puberty., PMID:30192028
MicroRNA-137 promotes hepatitis B virus gene expression and replication via targeting the protein inhibitor of activated STAT 2., PMID:29441983
The conserved ancient role of chordate PIAS as a multilevel repressor of the NF-κB pathway., PMID:29213053
The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery., PMID:29180619
SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation., PMID:29180403
Novel candidate genes of the PARK7 interactome as mediators of apoptosis and acetylation in multiple sclerosis: An in silico analysis., PMID:29100048
Transcriptome Profiling Uncovers Potential Common Mechanisms in Fetal Trisomies 18 and 21., PMID:29049012
Protein Inhibitor of Activated STAT2 Restricts HCV Replication by Modulating Viral Proteins Degradation., PMID:28973998
Differentially expressed JAK-STAT signaling pathway genes and target microRNAs in the spleen of necrotic enteritis-afflicted chicken lines., PMID:28525837
Alterations of ubiquitin related proteins in the pathology and development of schizophrenia: Evidence from human and animal studies., PMID:28226265
Crosstalk between androgen and pro-inflammatory signaling remodels androgen receptor and NF-κB cistrome to reprogram the prostate cancer cell transcriptome., PMID:27672034
SUMO Signaling by Hypoxic Inactivation of SUMO-Specific Isopeptidases., PMID:27626674
Protein Inhibitor of Activated STAT3 Regulates Migration, Invasion, and Activation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis., PMID:26667168
Decreased MIZ1 Expression in Severe Experimental Acute Pancreatitis: A Rat Study., PMID:26581215
PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS., PMID:26403403
TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation., PMID:26390157
Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7)., PMID:26388433
Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains., PMID:26223632
ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure., PMID:26175529
Investigation of genetic variants in ubiquitin enzyme genes involved in the modulation of neurodevelopmental processes: a role in schizophrenia susceptibility?, PMID:25578144
Ubiquitously expressed transcript is a novel interacting protein of protein inhibitor of activated signal transducer and activator of transcription 2., PMID:25434787
For research use only. Not for human or drug use.
