Catalog No.
YHB32501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ile187
Predicted molecular weight
23.79 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75838
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Calcium and integrin-binding family member 2, Kinase-interacting protein 2, KIP 2, CIB2, KIP2
Identification of biomarkers and potential drug targets in DFU based on fundamental experiments and multi-omics joint analysis., PMID:40487403
Identification of druggable binding sites and small molecules as modulators of TMC1., PMID:40360848
CIB2 function is distinct from that of whirlin in the organization of sterocilia architecture., PMID:40083274
The Diverse Functions of the Calcium- and Integrin-Binding Protein Family., PMID:40076845
Ankyrins are dispensable for mechanotransduction by cochlear hair cells., PMID:40024092
Structural insights into calcium-dependent CIB2-TMC1 interaction in hair cell mechanotransduction., PMID:40000792
Corrigendum to "Structural dynamics of calcium and integrin-binding protein 2 (CIB2) reveal uncommon flexibility and heterogeneous calcium and magnesium loading" [Int. J. Biol. Macromol. volume 286 (2025), 138003]., PMID:39946840
Mechano-electrical transduction components TMC1-CIB2 undergo a Ca2+-induced conformational change linked to hearing loss., PMID:39889697
Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels., PMID:39773557
Structural dynamics of calcium and integrin-binding protein 2 (CIB2) reveal uncommon flexibility and heterogeneous calcium and magnesium loading., PMID:39586446
CIB2 mediates acquired gefitinib resistance by inducing ZEB1 expression and epithelial-mesenchymal transition., PMID:39264588
LOXHD1 is indispensable for maintaining TMC1 auditory mechanosensitive channels at the site of force transmission., PMID:39256406
Transmembrane channel-like 4 and 5 proteins at microvillar tips are potential ion channels and lipid scramblases., PMID:39229161
CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase pattern., PMID:39131343
A large-scale screening identified in USH2A gene the P3272L founder pathogenic variant explaining familial Usher syndrome in Sardinia, Italy., PMID:39044131
Sequence variations and accessory proteins adapt TMC functions to distinct sensory modalities., PMID:38986620
Molecular Specializations Underlying Phenotypic Differences in Inner Ear Hair Cells of Zebrafish and Mice., PMID:38826418
Identification of Druggable Binding Sites and Small Molecules as Modulators of TMC1., PMID:38826329
Autosomal recessive non-syndromic hearing loss genes in Pakistan during the previous three decades., PMID:38534090
LOXHD1 is indispensable for coupling auditory mechanosensitive channels to the site of force transmission., PMID:38260480
Uncommon Protein-Coding Variants Associated With Suicide Attempt in a Diverse Sample of U.S. Army Soldiers., PMID:38141912
Differential expression of mechanotransduction complex genes in auditory/vestibular hair cells in zebrafish., PMID:38035267
Identification of biomarkers associated with the invasion of nonfunctional pituitary neuroendocrine tumors based on the immune microenvironment., PMID:37522128
Calcium and Integrin-binding protein 2 (CIB2) controls force sensitivity of the mechanotransducer channels in cochlear outer hair cells., PMID:37461484
Usher syndrome proteins ADGRV1 (USH2C) and CIB2 (USH1J) interact and share a common interactome containing TRiC/CCT-BBS chaperonins., PMID:37427378
Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels., PMID:37398045
CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling., PMID:37128899
CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells., PMID:37001993
Calcium- and Integrin-Binding Protein 2 (CIB2) in Physiology and Disease: Bright and Dark Sides., PMID:35408910
Identification of the shared gene signatures and pathways between sarcopenia and type 2 diabetes mellitus., PMID:35271662
Putting the Pieces Together: the Hair Cell Transduction Complex., PMID:34617206
BAIAP2L2 is required for the maintenance of mechanotransducing stereocilia of cochlear hair cells., PMID:34346063
Evaluation of Reliable Reference Genes for In Vitro Erythrocyte Generation from Cord Blood CD34+ Cells., PMID:34227876
Novel pathogenic mutations and further evidence for clinical relevance of genes and variants causing hearing impairment in Tunisian population., PMID:34194829
CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function., PMID:34162842
CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells., PMID:34089643
[Variation analysis of genes associated with Usher syndrome type 1 in 136 Chinese deafness families]., PMID:33730806
Arabidopsis CIB3 regulates photoperiodic flowering in an FKF1-dependent way., PMID:33686404
The Relationship of Sphingosine Kinase 1 With Pyroptosis Provides a New Strategy for Tumor Therapy., PMID:33123153
Genome-wide study of pineapple (Ananas comosus L.) bHLH transcription factors indicates that cryptochrome-interacting bHLH2 (AcCIB2) participates in flowering time regulation and abiotic stress response., PMID:33092537
CIB4 is essential for the haploid phase of spermatogenesis in mice†., PMID:32430498
Oligomeric state, hydrodynamic properties and target recognition of human Calcium and Integrin Binding protein 2 (CIB2)., PMID:31636333
Functional study of 14-3-3 protein epsilon (YWHAE) in keratinocytes: microarray integrating bioinformatics approaches., PMID:31244373
Proestrus Differentially Regulates Expression of Ion Channel and Calcium Homeostasis Genes in GnRH Neurons of Mice., PMID:31213979
High-throughput sequencing for the molecular diagnosis of Usher syndrome reveals 42 novel mutations and consolidates CEP250 as Usher-like disease causative., PMID:30459346
Function and Dysfunction of TMC Channels in Inner Ear Hair Cells., PMID:30291150
Preferential Binding of Mg2+ Over Ca2+ to CIB2 Triggers an Allosteric Switch Impaired in Usher Syndrome Type 1J., PMID:30174586
Genetic heterogeneity of congenital hearing impairment in Algerians from the Ghardaïa province., PMID:30055715
Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice., PMID:29255404
Variants in CIB2 cause DFNB48 and not USH1J., PMID:29112224
For research use only. Not for human or drug use.
