Catalog No.
YHB21501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr40-Arg340
Predicted molecular weight
35.48 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75462
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cytokine receptor-like factor 1, Cytokine-like factor 1, CLF-1, ZcytoR5, CRLF1, UNQ288/PRO327
High-yield production of recombinant CLCF1 protein fused with human serum albumin in animal cells and toxicity evaluation in rodents., PMID:40393625
A secretome atlas of cardiac fibroblasts from healthy and infarcted mouse hearts., PMID:40301568
CRLF1/CLCF1 heterodimer involvement in intervertebral disc degeneration via exacerbation of extracellular matrix degradation and nucleus pulposus cell senescence., PMID:39986601
Application of integrated omics in aseptic loosening of prostheses after hip replacement., PMID:39749710
Inhibition of CRLF1 expression by miR-8485 alleviates IL-1β-induced chondrocyte inflammation, apoptosis, and extracellular matrix degradation., PMID:39580860
Transcriptomic response of overexpression ZNF32 in breast cancer cells., PMID:39557972
CRLF1 bridges AKT and mTORC2 through SIN1 to inhibit pyroptosis and enhance chemo-resistance in ovarian cancer., PMID:39256356
Single-cell transcriptomic atlas of taste papilla aging., PMID:39169434
Tobacco smoking is associated with sex- and plaque-type specific upregulation of CRLF1 in atherosclerotic lesions., PMID:39137621
The role of cytokine receptor-like factor 1 (CRLF1) in facet joint osteoarthritis pathogenesis., PMID:39128688
ENO1 regulates IL-1β-induced chondrocyte inflammation, apoptosis and matrix degradation possibly through the potential binding to CRLF1., PMID:39116531
Cytokine Receptor-like Factor 1 (CRLF1) and Its Role in Osteochondral Repair., PMID:38727293
Identification and validation of CRLF1 and NRG1 as immune-related signatures in hypertrophic scar., PMID:38262564
Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1., PMID:37910254
Cytokine receptor-like factor 1 (CRLF1) promotes cardiac fibrosis via ERK1/2 signaling pathway., PMID:37551555
Transcriptome-wide profile of 1α,25 dihydroxyvitamin D3 in HTR-8/SVneo cells., PMID:37277920
Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype., PMID:36167601
Novel Mutations in CRLF1: Case Reports with Crisponi Syndrome., PMID:35984556
Clinical and molecular genetic findings of Crisponi/cold-induced sweating syndrome (CS/CISS) spectrum in patients from Turkey., PMID:35699517
Identification of proteins and N-glycosylation sites of knee cartilage in Kashin-Beck disease compared with osteoarthritis., PMID:35526762
CRLF1 and CLCF1 in Development, Health and Disease., PMID:35055176
miR-3065-3p promotes stemness and metastasis by targeting CRLF1 in colorectal cancer., PMID:34656128
Suppression of CRLF1 promotes the chondrogenic differentiation of bone marrow-derived mesenchymal stem and protects cartilage tissue from damage in osteoarthritis via activation of miR-320., PMID:34551709
Prioritization and functional analysis of GWAS risk loci for Barrett's esophagus and esophageal adenocarcinoma., PMID:34505128
Three new cases of Crisponi /cold induced sweating syndrome (CS/CISS1) in Turkish families., PMID:33910095
The enzymatic hydrolysates from deer sinew promote MC3T3-E1 cell proliferation and extracellular matrix synthesis by regulating multiple functional genes., PMID:33568122
TNRC6C Functions as a Tumor Suppressor and Is Frequently Downregulated in Papillary Thyroid Cancer., PMID:33564303
Crisponi/Cold Induced Sweating Syndrome Type 1 With a Private Cytokine Receptor Like Factor 1 (CRLF1) Mutation in an Indian Family., PMID:33231180
CRLF1-MYH9 Interaction Regulates Proliferation and Metastasis of Papillary Thyroid Carcinoma Through the ERK/ETV4 Axis., PMID:32982961
Expression Analysis of GDNF/RET Signaling Pathway in Human AD-MSCs Grown in HEK 293 Conditioned Medium (HEK293-CM)., PMID:32803668
Infant developmental profile of Crisponi syndrome due to compound heterozygosity for CRLF1 deletion., PMID:32433043
Cardiotrophin-Like Cytokine Factor 1 Exhibits a Myeloid-Biased Hematopoietic-Stimulating Function., PMID:31552057
Crisponi/cold-induced sweating syndrome: Differential diagnosis, pathogenesis and treatment concepts., PMID:31497877
AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction., PMID:31134766
Revisiting the combinatorial potential of cytokine subunits in the IL-12 family., PMID:30885765
Annotating Transcriptional Effects of Genetic Variants in Disease-Relevant Tissue: Transcriptome-Wide Allelic Imbalance in Osteoarthritic Cartilage., PMID:30298554
Cardiotrophin-like Cytokine Increases Macrophage-Foam Cell Transition., PMID:30209193
CRLF1 promotes malignant phenotypes of papillary thyroid carcinoma by activating the MAPK/ERK and PI3K/AKT pathways., PMID:29515111
Multiple Targets for Novel Therapy of FSGS Associated with Circulating Permeability Factor., PMID:28951873
A new case series of Crisponi syndrome in a Turkish family and review of the literature., PMID:27977424
Mutations in CRLF1 cause familial achalasia., PMID:27976805
Bi-allelic Mutations in KLHL7 Cause a Crisponi/CISS1-like Phenotype Associated with Early-Onset Retinitis Pigmentosa., PMID:27392078
Corneal alterations in Crisponi/CISS1 syndrome: A slit-lamp biomicroscopy and in vivo confocal microscopy corneal report., PMID:27054527
Crisponi/CISS1 syndrome: A case series., PMID:26804344
Yap and Taz are required for Ret-dependent urinary tract morphogenesis., PMID:26243870
Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders., PMID:26198769
Janus kinase 2/signal transducer and activator of transcription 3 inhibitors attenuate the effect of cardiotrophin-like cytokine factor 1 and human focal segmental glomerulosclerosis serum on glomerular filtration barrier., PMID:25843671
Despite differential gene expression profiles pediatric MDS derived mesenchymal stromal cells display functionality in vitro., PMID:25679997
A new Turkish infant with clinical features of CS/CISS1 syndrome and homozygous CRLF1 mutation., PMID:24613578
Expanding the mutational spectrum of CRLF1 in Crisponi/CISS1 syndrome., PMID:24488861
For research use only. Not for human or drug use.
