Catalog No.
YHB16501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn25-His428
Predicted molecular weight
47.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75356
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nucleoside diphosphate phosphatase ENTPD5, 3.6.1.6, CD39 antigen-like 4, ER-UDPase, Ectonucleoside triphosphate diphosphohydrolase 5, NTPDase 5, Guanosine-diphosphatase ENTPD5, GDPase ENTPD5, Inosine diphosphate phosphatase ENTPD5, Nucleoside diphosphatase, Uridine-diphosphatase ENTPD5, UDPase ENTPD5, ENTPD5, CD39L4, PCPH
Uracil as a biomarker for spatial pyrimidine metabolism in the development of gingivobuccal oral squamous cell carcinoma., PMID:38773214
Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs., PMID:38492367
CHRDL1, NEFH, TAGLN and SYNM as novel diagnostic biomarkers of benign prostatic hyperplasia and prostate cancer., PMID:37781794
Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis., PMID:37563605
The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation., PMID:36849424
PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6., PMID:36824269
Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity., PMID:35772218
Knockdown of ENTPD5 inhibits tumor metastasis and growth via regulating the GRP78/p-eIF-2α/CHOP pathway in serous ovarian cancer., PMID:35668504
ENTPD5 splice variants: novel players in cancer?, PMID:34272651
ENTPD5: identification of splicing variants and their impact on cancer survival., PMID:34075526
[ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics]., PMID:33963715
Development of Teleost Intermuscular Bones Undergoing Intramembranous Ossification Based on Histological-Transcriptomic-Proteomic Data., PMID:31546739
Identifying small molecule probes of ENTPD5 through high throughput screening., PMID:31242188
RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas., PMID:31062076
ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes., PMID:30201971
Transcriptomic Characterization of Endometrioid, Clear Cell, and High-Grade Serous Epithelial Ovarian Carcinoma., PMID:29967001
Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock., PMID:29624170
Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair., PMID:29405914
Targeted Pth4-expressing cell ablation impairs skeletal mineralization in zebrafish., PMID:29040309
p53 gain-of-function mutations promote metastasis via ENTPD5 upregulation and enhanced N-glycoprotein folding., PMID:28401189
Pro-metastatic p53 mutants control folding of N-glycoproteins., PMID:28166433
Extracellular Nucleotide Hydrolysis in Dermal and Limbal Mesenchymal Stem Cells: A Source of Adenosine Production., PMID:28120532
Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5., PMID:27956623
Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism., PMID:27832996
Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells., PMID:26704305
ENTPD5 induces apoptosis in lung cancer cells via regulating caspase 3 expression., PMID:25794010
4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice., PMID:25145583
Circulating miR-182 is a biomarker of colorectal adenocarcinoma progression., PMID:25115394
NTPDase5/PCPH as a new target in highly aggressive tumors: a systematic review., PMID:25045656
Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE)., PMID:24906371
Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications., PMID:24859727
Impact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis., PMID:23987127
The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family., PMID:23921441
Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction., PMID:23719831
Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish., PMID:23236130
ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme., PMID:22992974
ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells., PMID:22169232
The Warburg effect in 2012., PMID:22123234
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway., PMID:21074248
Integrating proteomic and transcriptomic high-throughput surveys for search of new biomarkers of colon tumors., PMID:21061036
Developmentally regulated expression of ectonucleotidases NTPDase5 and NTPDase6 and UDP-responsive P2Y receptors in the rat cochlea., PMID:20217113
Differential ectonucleotidase expression in human bladder cancer cell lines., PMID:19372055
Ectonucleoside triphosphate diphosphohydrolase type 5 (Entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest., PMID:19176496
PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Calpha-mediated Bcl-2 stabilization., PMID:19117992
E-NTPDases and ecto-5'-nucleotidase expression profile in rat heart left ventricle and the extracellular nucleotide hydrolysis by their nerve terminal endings., PMID:18201730
PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism., PMID:18006831
PCPH expression is an early event in the development of testicular germ cell tumors., PMID:16465363
Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase., PMID:15698960
Deregulated expression of the PCPH proto-oncogene in human breast cancers., PMID:15375529
Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia., PMID:12489110
For research use only. Not for human or drug use.
