Catalog No.
YHB15701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser20-Ser327
Predicted molecular weight
37.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75344
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Inactive peptidyl-prolyl cis-trans isomerase FKBP6, Inactive PPIase FKBP6, 36 kDa FK506-binding protein, 36 kDa FKBP, FKBP-36, FK506-binding protein 6, FKBP-6, Immunophilin FKBP36, FKBP6, FKBP36
Proteomic analysis of sperm from fertile stallions and subfertile stallions due to impaired acrosomal exocytosis., PMID:38816557
Analyzing aberrant DNA methylation in colorectal cancer uncovered intangible heterogeneity of gene effects in the survival time of patients., PMID:38092774
Lactate-induced spontaneous acrosomal exocytosis as a method to study acrosome function in stallion sperm., PMID:37517302
In vivo versus in silico assessment of potentially pathogenic missense variants in human reproductive genes., PMID:37459509
Analyzing aberrant DNA methylation in Colorectal cancer uncovered intangible heterogeneity of gene effects in the survival time of patients., PMID:37397988
The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans., PMID:36150389
Thoroughbred stallion fertility is significantly associated with FKBP6 genotype but not with inbreeding or the contribution of a leading sire., PMID:34610162
Fertility Relevance Probability Analysis Shortlists Genetic Markers for Male Fertility Impairment., PMID:33238277
Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes., PMID:32585002
Promoter hypermethylation of PIWI/piRNA pathway genes associated with diminished pachytene piRNA production in bovine hybrid male sterility., PMID:32141383
Compression of Large Sets of Sequence Data Reveals Fine Diversification of Functional Profiles in Multigene Families of Proteins: A Study for Peptidyl-Prolyl cis/trans Isomerases (PPIase)., PMID:30754725
Analysis of Canadian multiple sclerosis patients does not support a role for FKBP6 in disease., PMID:30298791
Evaluation of specific germ cell genes expression in mouse embryonic stem cell-derived germ cell like cells treated with bone morphogenetic protein 4 in vitro., PMID:30288485
Evaluation of Novel Mouse-Specific Germ Cell Gene Expression in Embryonic Stem Cell-Derived Germ Cell-Like Cells In Vitro with Retinoic Acid Treatment., PMID:30089026
Linkage analysis and whole exome sequencing identify a novel candidate gene in a Dutch multiple sclerosis family., PMID:29873607
In silico analysis of single-cell RNA sequencing data from 3 and 7 days old mouse spermatogonial stem cells to identify their differentially expressed genes and transcriptional regulators., PMID:29749669
Comparative analysis of single-cell RNA sequencing data from mouse spermatogonial and mesenchymal stem cells to identify differentially expressed genes and transcriptional regulators of germline cells., PMID:29194616
Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes., PMID:27671338
Differential DNA methylation of the meiosis-specific gene FKBP6 in testes of yak and cattle-yak hybrids., PMID:27658575
Fertility Assessment in Sorraia Stallions by Sperm-Fish and Fkbp6 Genotyping., PMID:27020485
Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?, PMID:26740066
Involvement of FKBP6 in hepatitis C virus replication., PMID:26567527
Gene structure variation in segmental duplication block C of human chromosome 7q 11.23 during primate evolution., PMID:26196062
Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression., PMID:26025256
Implication of FKBP6 for male fertility in horses., PMID:25495881
HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse., PMID:25262350
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways., PMID:25036637
Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population., PMID:24241165
Genome-wide association study implicates testis-sperm specific FKBP6 as a susceptibility locus for impaired acrosome reaction in stallions., PMID:23284302
A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing., PMID:22902560
Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52., PMID:22416080
NEK1 Facilitates Cohesin Removal during Mammalian Spermatogenesis., PMID:21931878
Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study., PMID:20210997
FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor., PMID:19001379
FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes., PMID:18529014
Affected homologous chromosome pairing and phosphorylation of testis specific histone, H2AX, in male meiosis under FKBP6 deficiency., PMID:18408354
Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men., PMID:17307919
Is a genetic defect in Fkbp6 a common cause of azoospermia in humans?, PMID:16983454
Mutations in the chromosome pairing gene FKBP6 are not a common cause of non-obstructive azoospermia., PMID:16227348
Autosomal dominant inheritance of Williams-Beuren syndrome in a father and son with haploinsufficiency for FKBP6., PMID:15770126
[Possible association between 278C/A single nucleotide polymorphism of FKBP6 and idiopathic azoospermia]., PMID:15696470
Fine mapping of a region of rat chromosome 12 close to the aspermia (as) locus and comparison with the human orthologous regions., PMID:15516791
TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint., PMID:14718568
GTF2I hemizygosity implicated in mental retardation in Williams syndrome: genotype-phenotype analysis of five families with deletions in the Williams syndrome region., PMID:14556246
Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis., PMID:12764197
Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family., PMID:11710534
A novel human gene FKBP6 is deleted in Williams syndrome., PMID:9782077
For research use only. Not for human or drug use.
