Catalog No.
YHB10601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr44-Gly310
Predicted molecular weight
32.75 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75150
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E3 ubiquitin-protein ligase BRE1B, BRE1-B, 2.3.2.27, 95 kDa retinoblastoma-associated protein, RBP95, RING finger protein 40, RING-type E3 ubiquitin transferase BRE1B, RNF40, BRE1B, KIAA0661
USP14-IMP2-CXCL2 axis in tumor-associated macrophages facilitates resistance to anti-PD-1 therapy in gastric cancer by recruiting myeloid-derived suppressor cells., PMID:40269263
Exploring breast cancer associated-gene panel for next-generation sequencing and identifying new, pathogenic variants in breast cancer from western China., PMID:39895796
Rnf40 Exacerbates Hypertension-Induced Cerebrovascular Endothelial Barrier Dysfunction by Ubiquitination and Degradation of Parkin., PMID:39777866
LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism., PMID:38909032
Structure of the human Bre1 complex bound to the nucleosome., PMID:38519511
Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes., PMID:38517892
The H2Bub1-deposition complex is required for human and mouse cardiogenesis., PMID:38038666
KSHV RTA utilizes the host E3 ubiquitin ligase complex RNF20/40 to drive lytic reactivation., PMID:37888983
RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer., PMID:37770435
Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A., PMID:37633270
RNF20/RNF40 ameliorates streptozotocin-induced type 1 diabetes by activating vitamin D receptors in vivo., PMID:37422774
H2Bub1 loss is an early contributor to clear cell ovarian cancer progression., PMID:37345659
Wee1 epigenetically modulates H2B mono-ubiquitination at K120 lysine and DNA double-strand break repair through phosphorylation of H2BY37-dependent manner in small-cell lung cancer., PMID:37102239
The roles of the tumor suppressor parafibromin in cancer., PMID:36211470
A novel long non-coding RNA, lnc-RNU12, influences the T-cell cycle via c-JUN and CCNL2 in rheumatoid arthritis., PMID:36165706
DNA Damage Induction Alters the Expression of Ubiquitin and SUMO Regulators in Preimplantation Stage Pig Embryos., PMID:36077022
Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease., PMID:35954248
Immunotherapeutic Significance of a Prognostic Alternative Splicing Signature in Bladder Cancer., PMID:35509211
Novel variant of ETFDH leading to multiple acyl-CoA dehydrogenase deficiency by promoting protein degradation via ubiquitin proteasome pathway., PMID:35314173
M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression., PMID:35303054
Screening of Important Markers in Peripheral Blood Mononuclear Cells to Predict Female Osteoporosis Risk Using LASSO Regression Algorithm and SVM Method., PMID:35110962
Comprehensive Atlas of the Myelin Basic Protein Interaction Landscape., PMID:34827627
TRIM40 inhibits IgA1-induced proliferation of glomerular mesangial cells by inactivating NLRP3 inflammasome through ubiquitination., PMID:34763147
Protease cleavage of RNF20 facilitates coronavirus replication via stabilization of SREBP1., PMID:34452991
Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation., PMID:34290256
RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease., PMID:34088983
Exercise training effects on natural killer cells: a preliminary proteomics and systems biology approach., PMID:33965896
COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks., PMID:33875784
Ring finger 20/ring finger 40/WW domain-containing adaptor with coiled-coil complex interacts with p53 to regulate gene transcription in DNA damage response., PMID:33868474
Role of H2B mono-ubiquitination in the initiation and progression of cancer., PMID:33685627
Cullin 7 in tumor development: a novel potential anti-cancer target., PMID:33618520
Histone Monoubiquitination in Chromatin Remodelling: Focus on the Histone H2B Interactome and Cancer., PMID:33233707
Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis., PMID:33199825
The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis., PMID:33070155
RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk., PMID:32901120
Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination., PMID:32672815
The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming., PMID:32341358
The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells., PMID:31266541
Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility., PMID:31235600
LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet β-cell function., PMID:31186351
The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing., PMID:31152661
E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair., PMID:30692271
Writing Histone Monoubiquitination in Human Malignancy-The Role of RING Finger E3 Ubiquitin Ligases., PMID:30669413
RNF20/40-mediated eEF1BδL monoubiquitylation stimulates transcription of heat shock-responsive genes., PMID:30649429
Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice., PMID:30321325
Role of RNF20 in cancer development and progression - a comprehensive review., PMID:29934362
High RNF40 expression indicates poor prognosis of hepatocellular carcinoma., PMID:31938414
Comparative Proteomics of Dying and Surviving Cancer Cells Improves the Identification of Drug Targets and Sheds Light on Cell Life/Death Decisions., PMID:29572246
CRL7SMU1 E3 ligase complex-driven H2B ubiquitylation functions in sister chromatid cohesion by regulating SMC1 expression., PMID:29507117
Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response., PMID:29413288
For research use only. Not for human or drug use.
