Catalog No.
YHB07801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met107-Gly489
Predicted molecular weight
46.19 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75077
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Disintegrin and metalloproteinase domain-containing protein 23, ADAM 23, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3, MDC-3, ADAM23, MDC3
Biallelic LGI1 and ADAM23 variants cause hippocampal epileptic encephalopathy via the LGI1-ADAM22/23 pathway., PMID:40455867
Integrated lncRNA and mRNA Transcriptome Analyses of IGF1 and IGF2 Stimulated Ovaries Reveal Genes and Pathways Potentially Associated with Ovarian Development and Oocyte Maturation in Golden Pompano (Trachinotus ovatus)., PMID:40281968
Novel synaptic markers predict early tau pathology and cognitive deficit in an asymptomatic population at risk of Alzheimer's disease., PMID:39827219
Novel risk loci in LGI1-antibody encephalitis: genome-wide association study discovery and validation cohorts., PMID:39454566
Causal inference of the effect of blood proteome on the risk of head and neck cancer: two-sample Mendelian randomization., PMID:38985358
Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission., PMID:38700985
Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity., PMID:38194969
Circulating Biomarkers and Risk of Hypertension: A Two-Sample Mendelian Randomisation Study., PMID:38042639
Plasma levels of neurology-related proteins are associated with cognitive performance in an older population with overweight/obesity and metabolic syndrome., PMID:36964401
LGI3/2-ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period., PMID:36828548
ARID2 suppression promotes tumor progression and upregulates cytokeratin 8, 18 and β-4 integrin expression in TP53-mutated tobacco-related oral cancer and has prognostic implications., PMID:35869277
Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke., PMID:35213696
Mechanism and Role of the Neuropeptide LGI1 Receptor ADAM23 in Regulating Biomarkers of Ferroptosis and Progression of Esophageal Cancer., PMID:35003396
Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells., PMID:34827207
Multiomics Differences in Lung Squamous Cell Carcinoma Patients with High Radiosensitivity Index Compared with Those with Low Radiosensitivity Index., PMID:34504628
Dissecting the transcriptional program of phosphomannomutase 2-deficient cells: Lymphoblastoide B cell lines as a valuable model for congenital disorders of glycosylation studies., PMID:34420056
Prognostic value of tumour microenvironment-related genes by TCGA database in rectal cancer., PMID:33949771
Endocytosis of the non-catalytic ADAM23: Recycling and long half-life properties., PMID:33296662
Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke., PMID:33173895
Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms., PMID:32437528
Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system., PMID:31236626
ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents., PMID:30965109
A disintegrin and metalloprotease 23 hypermethylation predicts decreased disease-free survival in low-risk breast cancer patients., PMID:30815959
ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment., PMID:30598502
ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK - AKT Signaling., PMID:30371220
LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory., PMID:30346486
Decreased methylation in the SNAI2 and ADAM23 genes associated with de-differentiation and haematogenous dissemination in breast cancers., PMID:30189837
Low levels of ADAM23 expression in epithelial ovarian cancer are associated with poor survival., PMID:29921495
Monoclonal Antibody DL11C8 Identifies ADAM23 as a Component of Lipid Raft Microdomains., PMID:29792904
Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22., PMID:29670100
Culturing conditions highly affect DNA methylation and gene expression levels in MCF7 breast cancer cell line., PMID:29633080
Histone H3.3K27M Mobilizes Multiple Cancer/Testis (CT) Antigens in Pediatric Glioma., PMID:29453317
Beyond the Proteolytic Activity: Examining the Functional Relevance of the Ancillary Domains Using Tri-Dimensional (3D) Spheroid Invasion Assay., PMID:29318552
Multiple non-catalytic ADAMs are novel integrin α4 ligands., PMID:28913673
ADAM23 promotes neuronal differentiation of human neural progenitor cells., PMID:28828010
Leucine-rich glioma inactivated 3: integrative analyses support its prognostic role in glioma., PMID:28579810
Leucine-rich glioma inactivated 3: Integrative analyses support its role in the cytokine network., PMID:28534931
Oxidative stress and genes regulation of cerebral malaria upon Zizyphus spina-christi treatment in a murine model., PMID:28336326
ADAM23 is a common risk gene for canine idiopathic epilepsy., PMID:28143391
Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor., PMID:27317750
Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors., PMID:27760137
Expression of SOCS1 and CXCL12 Proteins in Primary Breast Cancer Are Associated with Presence of Circulating Tumor Cells in Peripheral Blood., PMID:27267835
Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris., PMID:27152848
ADAM23 is downregulated in side population and suppresses lung metastasis of lung carcinoma cells., PMID:26800504
Identification of a common risk haplotype for canine idiopathic epilepsy in the ADAM23 gene., PMID:26084559
Autistic and Rett-like features associated with 2q33.3-q34 interstitial deletion., PMID:25899208
Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes., PMID:25707359
Leucine-rich glioma inactivated 3 and tumor necrosis factor-α regulate mutually through NF-κB., PMID:25648289
CXCL12 and ADAM23 hypermethylation are associated with advanced breast cancers., PMID:25620615
LGI1: from zebrafish to human epilepsy., PMID:25194489
For research use only. Not for human or drug use.
