Catalog No.
YHB07201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln61-Leu409
Predicted molecular weight
41.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75063
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Glycosaminoglycan xylosylkinase, 2.7.1.-, Xylose kinase, FAM20B, KIAA0475
FAM20B Gain-of-Function Blocks the Synthesis of Glycosaminoglycan Chains of Proteoglycans and Inhibits Proliferation and Migration of Glioblastoma Cells., PMID:40422215
Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues., PMID:40385441
FAM20B-Catalyzed Glycosylation Regulates the Chondrogenic and Osteogenic Differentiation of the Embryonic Condyle by Controlling IHH Diffusion and Release., PMID:40362273
Enhancement of Chondrogenic Differentiation in Bone Marrow-Derived Stem Cell Spheroids by Cuminum cyminum Methanolic Extract: Insights into Concentration-Dependent mRNA Expression and Gene Clustering Analysis., PMID:39728055
Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice., PMID:38861581
Matrisome Transcriptome Dynamics during Tissue Aging., PMID:38792614
An EWAS of dementia biomarkers and their associations with age, African ancestry, and PTSD., PMID:38431614
Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice., PMID:38187647
Proteoglycan inhibition of canonical BMP-dependent cartilage maturation delays endochondral ossification., PMID:38117077
Molecular mechanism of decision-making in glycosaminoglycan biosynthesis., PMID:37828045
Deficiency of Fam20b-Catalyzed Glycosaminoglycan Chain Synthesis in Neural Crest Leads to Cleft Palate., PMID:37298583
Family with sequence similarity 20 member B regulates osteogenic differentiation of bone marrow mesenchymal stem cells on titanium surfaces., PMID:36871775
Phosphorylation and sulfation share a common biosynthetic pathway, but extend biochemical and evolutionary diversity of biological macromolecules in distinct ways., PMID:35919982
Matrisome alterations in obesity - Adipose tissue transcriptome study on monozygotic weight-discordant twins., PMID:35227930
Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice., PMID:33905568
The ABCs of the atypical Fam20 secretory pathway kinases., PMID:33759783
FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling., PMID:32664967
Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease., PMID:32517548
The spatiotemporal expression pattern of Syndecans in murine embryonic teeth., PMID:32220631
Inactivation of FAM20B causes cell fate changes in annulus fibrosus of mouse intervertebral disc and disc defects via the alterations of TGF-β and MAPK signaling pathways., PMID:31513834
Lack of association between PAX6/SOSTDC1/FAM20B gene polymorphisms and mesiodens., PMID:31133012
A novel gene (FAM20B encoding glycosaminoglycan xylosylkinase) for neonatal short limb dysplasia resembling Desbuquois dysplasia., PMID:30847897
Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects., PMID:30105814
Structure and evolution of the Fam20 kinases., PMID:29572475
Methods to Purify and Assay Secretory Pathway Kinases., PMID:27632012
Inactivation of Fam20B in Joint Cartilage Leads to Chondrosarcoma and Postnatal Ossification Defects., PMID:27405802
Inactivation of Fam20B in the dental epithelium of mice leads to supernumerary incisors., PMID:26465965
Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis., PMID:25331875
Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans., PMID:24425863
EXTL2 controls liver regeneration and aortic calcification through xylose kinase-dependent regulation of glycosaminoglycan biosynthesis., PMID:24176719
Crystal structure of the Golgi casein kinase., PMID:23754375
EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner., PMID:23395820
Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice., PMID:22732358
Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation., PMID:21901110
FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region., PMID:19473117
FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells., PMID:15676076
For research use only. Not for human or drug use.
