Catalog No.
YHB03601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys27-Leu119
Predicted molecular weight
38.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60894
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Receptor activity-modifying protein 1, Calcitonin-receptor-like receptor activity-modifying protein 1, CRLR activity-modifying protein 1, RAMP1
Intra-tumoural RAMP1+ B cells promote resistance to neoadjuvant anti-PD-1-based therapy in oesophageal squamous cell carcinoma., PMID:40385640
Genome-wide Mendelian randomization study identifies therapeutic targets for diabetic microangiopathy., PMID:40349847
Nociceptive neurons promote gastric tumour progression via a CGRP-RAMP1 axis., PMID:39972142
Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis., PMID:39960341
Novel insights into the study of goblet cell hypersecretion in allergic rhinitis., PMID:39958344
The Role of TRPV1/CGRP Pathway Activated by Prevotella melaninogenica in Pathogenesis of Oral Lichen Planus., PMID:39859376
Receptor activity-modifying protein 1 regulates the differentiation of mouse skin fibroblasts by downregulating α-SMA expression via suppression of high mobility group AT-hook 1 to promote skin wound repair., PMID:39839760
CaV3.2 T-type calcium channels contribute to CGRP- induced allodynia in a rodent model of experimental migraine., PMID:39695919
Human RAMP1 overexpressing mice are resistant to migraine therapies for motion sensitivity., PMID:39652533
Sex differences in expression of CGRP family of receptors and ligands in the rat trigeminal system., PMID:39516766
Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice., PMID:39504351
Loss of Calcitonin Gene Related Receptor component protein (RCP) in nervous system can bias "gepant" antagonism., PMID:39484482
Sensory neuroimmune signaling in the pathogenesis of Stevens-Johnson syndrome and toxic epidermal necrolysis., PMID:39481654
N-(4-methoxyphenyl) quinoline-8-sulfonamide reduces the inflammatory response of fibroblast-like synoviocytes by targeting receptor (calcitonin) activity modifying protein 1 in rheumatoid arthritis., PMID:39427859
Amylin receptor subunit interactions are modulated by agonists and determine signaling., PMID:39416010
ILC2-derived CGRP triggers acute inflammation and nociceptive responses in bacterial cystitis., PMID:39412984
Differential expression of components of the CGRP-receptor family in human coronary and human middle meningeal arteries: functional implications., PMID:39390360
Calcitonin gene-related peptide promotes epithelial reparative and anticolitic functions of IL-4 educated human macrophages., PMID:39378308
Receptor activity-modifying protein modulation of parathyroid hormone-1 receptor function and signaling., PMID:39376604
RAMP1 Signaling Mitigates Acute Lung Injury by Distinctively Regulating Alveolar and Monocyte-Derived Macrophages., PMID:39337592
Spinal RAMP1-mediated neuropathic pain sensitisation in the aged mice through the modulation of CGRP-CRLR pain signalling., PMID:39224276
Sensory nerves drive migration of dental pulp stem cells via the CGRP-Ramp1 axis in pulp repair., PMID:39196292
Identification of crosstalk genes and immune characteristics between Alzheimer's disease and atherosclerosis., PMID:39188714
Lack of RAMP1 Signaling Suppresses Liver Regeneration and Angiogenesis Following Partial Hepatectomy in Mice., PMID:39187322
High-sensitive sensory neurons exacerbate rosacea-like dermatitis in mice by activating γδ T cells directly., PMID:39179539
Signalling of the neuropeptide calcitonin gene-related peptide (CGRP) through RAMP1 promotes liver fibrosis via TGFβ1/Smad2 and YAP pathways., PMID:39103072
A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice., PMID:39067134
Neuroimmune modulating and energy supporting nanozyme-mimic scaffold synergistically promotes axon regeneration after spinal cord injury., PMID:38970101
Involvement of RAMP1/p38MAPK signaling pathway in osteoblast differentiation in response to mechanical stimulation: a preliminary study., PMID:38825686
Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity., PMID:38772371
Variable CGRP family peptide signaling durations and the structural determinants thereof., PMID:38670438
RAMP1 Protects Hepatocytes against Ischemia-reperfusion Injury by Inhibiting the ERK/YAP Pathway., PMID:38638379
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein., PMID:38603770
CGRP sensory neurons promote tissue healing via neutrophils and macrophages., PMID:38538784
Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder., PMID:38509197
Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists., PMID:38458773
The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota., PMID:38451947
Deletion of RAMP1 Signaling Enhances Diet-induced Obesity and Fat Absorption via Intestinal Lacteals in Mice., PMID:38148085
Characteristics associated with response to subcutaneously administered anti-CGRP monoclonal antibody medications in a real-world community cohort of persons living with migraine: A retrospective clinical and genetic study., PMID:38071464
Antinociceptive effect of the calcitonin gene-related peptide receptor antagonist BIBN4096BS in mice with bacterial cystitis., PMID:37823199
RAMP1 as a novel prognostic biomarker in pan-cancer and osteosarcoma., PMID:37796823
The role of vesicle trafficking genes in osteoblast differentiation and function., PMID:37752218
The Anti-Calcitonin Gene-Related Peptide (Anti-CGRP) Antibody Fremanezumab Reduces Trigeminal Neurons Immunoreactive to CGRP and CGRP Receptor Components in Rats., PMID:37686275
Pharmacological characterisation of erenumab, Aimovig, at two calcitonin gene-related peptide responsive receptors., PMID:37580864
Body weight lowering effect of glucose-dependent insulinotropic polypeptide and glucagon-like peptide receptor agonists is more efficient in RAMP1/3 KO than in WT mice., PMID:37454968
Calcitonin Related Polypeptide Alpha Mediates Oral Cancer Pain., PMID:37443709
Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein-coupled receptor., PMID:37146967
Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine., PMID:37101198
Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival., PMID:37078547
Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins., PMID:37003505
For research use only. Not for human or drug use.
