Catalog No.
YHB02401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg153
Predicted molecular weight
19.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60858
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E3 ubiquitin-protein ligase TRIM13, 2.3.2.27, B-cell chronic lymphocytic leukemia tumor suppressor Leu5, Leukemia-associated protein 5, Putative tumor suppressor RFP2, RING finger protein 77, RING-type E3 ubiquitin transferase TRIM13, Ret finger protein 2, Tripartite motif-containing protein 13, TRIM13, LEU5, RFP2, RNF77
The Role and Mechanism of TRIM13 Regulation of TRAF6 Ubiquitination in the Synergy of Inflammatory Responses and Neurotoxicity Induced by METH and HIV- 1 Tat Protein in Astrocytes., PMID:40192895
Blood DDIT4 and TRIM13 Transcript Levels Mark the Early Stages of Machado-Joseph Disease., PMID:40041945
Alternative Splicing Events and Differently Expressed Genes During Peak Mortality in Large Yellow Croaker (Larimichthys crocea) Infected with Scuticociliate., PMID:39833483
RBM15-dependent m6A modification mediates progression of non-small cell lung cancer cells., PMID:39716068
Methamphetamine and HIV-1 Tat Protein Synergistically Induce Endoplasmic Reticulum Stress to Promote TRIM13-Mediated Neuronal Autophagy., PMID:39714526
Trim13-induced ubiquitination of RPS27A inhibits the progression of lung cancer by depending on the inactivation of NF-κB signaling pathway., PMID:39667820
Avian TRIM13 attenuates antiviral innate immunity by targeting MAVS for autophagic degradation., PMID:39508267
TRIM13 Reduces Damage to Alveolar Epithelial Cells in COPD by Inhibiting Endoplasmic Reticulum Stress-Induced ER-Phagy., PMID:39382594
Novel MIR143HG::PLAG1 gene fusion identified in a rectal myxoid leiomyosarcoma., PMID:38656544
TRIM13 reduces cholesterol efflux and increases oxidized LDL uptake leading to foam cell formation and atherosclerosis., PMID:38537695
Inhibition of ALKBH5 inhibits inflammation and excessive proliferation by promoting TRIM13 m6A modifications in glomerular mesangial cells., PMID:38536435
TRIM13 inhibits cell proliferation and induces autophagy in lung adenocarcinoma by regulating KEAP1/NRF2 pathway., PMID:37245083
Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development., PMID:37205848
Ubiquitination of SARS-CoV-2 NSP6 and ORF7a Facilitates NF-κB Activation., PMID:35856559
The transmembrane endoplasmic reticulum-associated E3 ubiquitin ligase TRIM13 restrains the pathogenic-DNA-triggered inflammatory response., PMID:35080984
PLAG1-rearrangment in a uterine leiomyosarcoma with myxoid stroma and heterologous differentiation., PMID:34184333
Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia., PMID:33206936
Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression., PMID:33087562
Development of Autophagy Signature-Based Prognostic Nomogram for Refined Glioma Survival Prognostication., PMID:32964017
Brain-specific deletion of TRIM13 promotes metabolic stress-triggered insulin resistance, glucose intolerance, and neuroinflammation., PMID:32446357
Altered DNA methylation of TRIM13 in diabetic nephropathy suppresses mesangial collagen synthesis by promoting ubiquitination of CHOP., PMID:31901873
TRIM13 inhibits cell migration and invasion in clear-cell renal cell carcinoma., PMID:31762344
Regulation of reticulophagy by the N-degron pathway., PMID:31744379
Identification of Biomolecular Information in Rotenone-Induced Cellular Model of Parkinson's Disease by Public Microarray Data Analysis., PMID:31593492
The N-Degron Pathway Mediates ER-phagy., PMID:31375263
TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells., PMID:31357025
Theragnosis by a miR-141-3p molecular beacon: simultaneous detection and sensitization of 5-fluorouracil resistant colorectal cancer cells through the activation of the TRIM13-associated apoptotic pathway., PMID:31184647
Ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 inhibits inflammation by regulating Nur77 stability., PMID:30905540
Bioinformatics analysis of prognostic value of TRIM13 gene in breast cancer., PMID:30837324
Knockdown of MAML1 inhibits proliferation and induces apoptosis of T-cell acute lymphoblastic leukemia cells through SP1-dependent inactivation of TRIM59., PMID:30370525
The E3 ubiquitin ligase Trim13 regulates Nur77 stability via casein kinase 2α., PMID:30224829
Cytogenetic Analysis of a Pseudoangiomatous Pleomorphic/Spindle Cell Lipoma., PMID:28476785
Trim13 Potentiates Toll-Like Receptor 2-Mediated Nuclear Factor κB Activation via K29-Linked Polyubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6., PMID:28087809
Grouper TRIM13 exerts negative regulation of antiviral immune response against nodavirus., PMID:27235367
TRIM13 regulates ubiquitination and turnover of NEMO to suppress TNF induced NF-κB activation., PMID:25152375
Participation of the E3-ligase TRIM13 in NF-κB p65 activation and NFAT-dependent activation of c-Rel upon T-cell receptor engagement., PMID:25088585
TRIM13 is a negative regulator of MDA5-mediated type I interferon production., PMID:25008915
Unveiling the degradative route of the V247M α-sarcoglycan mutant responsible for LGMD-2D., PMID:24565866
Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort., PMID:24252472
TRIM13 regulates caspase-8 ubiquitination, translocation to autophagosomes and activation during ER stress induced cell death., PMID:24021263
TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF Kappa B pathway and proteasome activity., PMID:23647456
TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells., PMID:22178386
TRIM proteins and cancer., PMID:21979307
Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2., PMID:21333377
The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels., PMID:21186355
A novel therapeutic combination for neuroblastoma: the vascular endothelial growth factor receptor/epidermal growth factor receptor/rearranged during transfection inhibitor vandetanib with 13-cis-retinoic acid., PMID:20225331
The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD., PMID:17314412
Human RFP2 gene promoter: unique structure and unusual strength., PMID:16499869
DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse., PMID:15188451
Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse: multiple mRNA isoforms in both species- and human-specific antisense transcript RFP2OS., PMID:14636997
For research use only. Not for human or drug use.
