Catalog No.
YHA98501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val147-Leu386
Predicted molecular weight
29.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60711
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Leupaxin, LPXN, LDLP
SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers., PMID:40473600
Leupaxin promotes hepatic gluconeogenesis and glucose metabolism by coactivation with hepatic nuclear factor 4α., PMID:39603504
Bioinformatics analysis of BTK expression in lung adenocarcinoma: implications for immune infiltration, prognostic biomarkers, and therapeutic targeting., PMID:39220827
STAT3 mediates ECM stiffness-dependent progression in ovarian cancer., PMID:38625514
Paxillin family proteins Hic-5 and LPXN promote lipid storage by regulating the ubiquitination degradation of CIDEC., PMID:38159847
Protein tyrosine kinase 2b inhibition reverts niche-associated resistance to tyrosine kinase inhibitors in AML., PMID:36056084
A protein coupling and molecular simulation analysis of the clinical mutants of androgen receptor revealed a higher binding for Leupaxin, to increase the prostate cancer invasion and motility., PMID:35504219
Construction of a microenvironment immune gene model for predicting the prognosis of endometrial cancer., PMID:34763648
Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG., PMID:34118218
Clinicopathological Significances of Cancer Stem Cell-Associated HHEX Expression in Breast Cancer., PMID:33425911
The molecular basis of gender disparities in smoking lung cancer patients., PMID:33358908
Leupaxin Expression Is Dispensable for B Cell Immune Responses., PMID:32269569
Macrophage Migration and Phagocytosis Are Controlled by Kindlin-3's Link to the Cytoskeleton., PMID:32094207
A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability., PMID:31537712
Downregulation of LPXN expression by siRNA decreases the malignant proliferation and transmembrane invasion of SHI-1 cells., PMID:30655748
[Small interfering RNA-mediated LPXN silencing suppresses proliferation and enhances drug sensitivity of human acute monocytic leukemia SHI-1 cells in vitro]., PMID:33168498
Leupaxin Promotes Bladder Cancer Proliferation, Metastasis, and Angiogenesis Through the PI3K/AKT Pathway., PMID:29975926
Acute myeloid leukemia carrying ETV6 mutations: biologic and clinical features., PMID:29894279
[Effect of LPXN Overexpression on the Proliferation, Adhesion and Invasion of THP-1 Cells and Its Mechamisms]., PMID:28641616
Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats., PMID:26866573
ETV6-LPXN fusion transcript generated by t(11;12)(q12.1;p13) in a patient with relapsing acute myeloid leukemia with NUP98-HOXA9., PMID:26542893
Regulation of β-catenin transcription activity by leupaxin in hepatocellular carcinoma., PMID:26361959
Leupaxin stimulates adhesion and migration of prostate cancer cells through modulation of the phosphorylation status of the actin-binding protein caldesmon., PMID:26079947
Leupaxin is expressed in mammary carcinoma and acts as a transcriptional activator of the estrogen receptor α., PMID:25955236
[Molecular mechanisms of leupaxin involved in prostate carcinoma metastasis]., PMID:23862238
Elucidation of a novel Vibrio cholerae lipid A secondary hydroxy-acyltransferase and its role in innate immune recognition., PMID:21752109
17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli., PMID:21653234
Identification of NDRG1-regulated genes associated with invasive potential in cervical and ovarian cancer cells., PMID:21463610
Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading., PMID:20543562
LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin., PMID:19917054
LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation., PMID:19760607
Leupaxin acts as a mediator in prostate carcinoma progression through deregulation of p120catenin expression., PMID:19701244
Oncogenic NRAS has multiple effects on the malignant phenotype of human melanoma cells cultured in vitro., PMID:18814281
The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription., PMID:18497331
Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells., PMID:18451096
Leupaxin negatively regulates B cell receptor signaling., PMID:17640867
Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells., PMID:17329398
Association of leupaxin with Src in osteoclasts., PMID:16914530
Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis., PMID:15914563
Leupaxin binds to PEST domain tyrosine phosphatase PEP., PMID:15786712
Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast., PMID:12674328
Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses., PMID:10604475
Leupaxin is a novel LIM domain protein that forms a complex with PYK2., PMID:9565592
For research use only. Not for human or drug use.
