Catalog No.
YHA92601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ala248
Predicted molecular weight
29.74 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60496
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Docking protein 2, Downstream of tyrosine kinase 2, p56(dok-2), DOK2
Bioinformatics-based identification of CTSS, DOK2, and ENTPD1 as potential blood biomarkers of schizophrenia., PMID:39972407
Exploring potential therapeutic targets for asthma: a proteome-wide Mendelian randomization analysis., PMID:39472987
DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing., PMID:38956389
Docking Proteins Upregulate IL-1β Expression in Lower Esophageal Sphincter Muscle in Esophageal Achalasia., PMID:38792545
Molecular incompatibility between pig CD200 and human CD200 receptor in in vitro xenogeneic immune responses., PMID:38751087
23ME-00610, a genetically informed, first-in-class antibody targeting CD200R1 to enhance antitumor T cell function., PMID:37288324
CD200 as a Potential New Player in Inflammation during Rotator Cuff Tendon Injury/Repair: An In Vitro Model., PMID:36499497
Comprehensive analysis of DOK family genes expression, immune characteristics, and drug sensitivity in human tumors., PMID:35127166
Signaling by the inhibitory receptor CD200R is rewired by type I interferon., PMID:34637328
Introduction to DOK2 and its potential role in cancer., PMID:34505522
LncRNA HOTAIR regulates anoikis-resistance capacity and spheroid formation of ovarian cancer cells by recruiting EZH2 and influencing H3K27 methylation., PMID:33502891
Analysis of prognostic genes in the tumor microenvironment of lung adenocarcinoma., PMID:32775050
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression., PMID:31707051
The Zinc Transporter Zip7 Is Downregulated in Skeletal Muscle of Insulin-Resistant Cells and in Mice Fed a High-Fat Diet., PMID:31266232
Insulin and insulin-like growth factors act as renal cell cancer intratumoral regulators., PMID:30929166
Long noncoding RNA AK089579 inhibits epithelial-to-mesenchymal transition of peritoneal mesothelial cells by competitively binding to microRNA-296-3p via DOK2 in peritoneal fibrosis., PMID:30652956
Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis., PMID:30475228
Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations., PMID:30206226
Expression of T-cell receptor signalling pathway components in extranodal NK/T-cell lymphoma., PMID:30102799
Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia., PMID:29548825
pDok2, caspase 3 dependent glioma cell growth arrest by nitidine chloride., PMID:29329030
Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis., PMID:29265183
Methylation-associated DOK1 and DOK2 down-regulation: Potential biomarkers for predicting adverse prognosis in acute myeloid leukemia., PMID:29150948
Co-expression and significance of Dok2 and Ras p21 protein activator 1 in breast cancer., PMID:29098030
Herpes simplex virus 1 infection of T cells causes VP11/12-dependent phosphorylation and degradation of the cellular protein Dok-2., PMID:28841444
Dok-1 and Dok-2 Are Required To Maintain Herpes Simplex Virus 1-Specific CD8+ T Cells in a Murine Model of Ocular Infection., PMID:28490594
Effects of expressing human T-cell leukemia virus type 1 (HTLV-I) oncoprotein Tax on DOK1, DOK2 and DOK3 gene expression in mice., PMID:28302940
Alteration of platelet GPVI signaling in ST-elevation myocardial infarction patients demonstrated by a combination of proteomic, biochemical, and functional approaches., PMID:28004756
Region-Specific Dok2 Overexpression Associates with Poor Prognosis in Human Astrocytoma., PMID:27975172
Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells., PMID:27664281
Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22., PMID:27450811
Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells., PMID:27265473
Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells., PMID:27183638
Plasma Autoantibodies Associated with Basal-like Breast Cancers., PMID:26070530
Dok proteins are recruited to the phagosome and degraded in a GP63-dependent manner during Leishmania major infection., PMID:25554486
Expression and significance of DOK2 in colorectal cancer., PMID:25435967
Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML)., PMID:25252871
Intracellular TCR-signaling pathway: novel markers for lymphoma diagnosis and potential therapeutic targets., PMID:25118816
Dok2 likely down-regulates Klf1 in mouse erythroleukemia cells., PMID:25075100
Dok1 and Dok2 proteins regulate natural killer cell development and function., PMID:24963146
mRNA expression of DOK1-6 in human breast cancer., PMID:24829863
Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice., PMID:24385425
DOK2 inhibits EGFR-mutated lung adenocarcinoma., PMID:24255704
Loss of DOK2 induces carboplatin resistance in ovarian cancer via suppression of apoptosis., PMID:23684582
Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia., PMID:23659921
Dok adaptors play anti-inflammatory roles in pulmonary homeostasis., PMID:23205702
A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation., PMID:23053573
Dok-1 overexpression promotes development of γδ natural killer T cells., PMID:22736313
Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia., PMID:22642833
Comparative analysis of platelet-derived microparticles reveals differences in their amount and proteome depending on the platelet stimulus., PMID:22415276
For research use only. Not for human or drug use.
