Catalog No.
YHA90801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg121
Predicted molecular weight
15.83 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60427
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Acyl-CoA (8-3)-desaturase, 1.14.19.44, Delta(5) fatty acid desaturase, D5D, Delta(5) desaturase, Delta-5 desaturase, Fatty acid desaturase 1, FADS1, FADSD5
Nut consumption, linoleic and α-linolenic acid intakes, and genetics: how fatty acid desaturase 1 impacts plasma fatty acids and type 2 diabetes risk in EPIC-InterAct and PREDIMED studies., PMID:40484934
Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes., PMID:40459498
Nutrigenetics and Omega-3 and Gamma-Linolenic Acid Intake and Status in Patients with Cancer: A PRISMA Scoping Review of Research Trends and Challenges., PMID:40430008
Multi-omics analysis unraveling stemness features associated with oncogenic dedifferentiation in 12 cancers., PMID:40412796
Influence of Fatty Acid Desaturase Enzyme-1 Gene (FADS-1) Polymorphism on Serum Polyunsaturated Fatty Acids Levels, Desaturase Enzymes, Lipid Profile, and Glycemic Control Parameters in Newly Diagnosed Diabetic Mellitus Patients., PMID:40362254
Targeting PSMD14 combined with arachidonic acid induces synthetic lethality via FADS1 m6A modification in triple-negative breast cancer., PMID:40344056
Identification, evolution, functional characterization and expression pattern of a fatty acyl desaturase (fads1) gene in Chinese sturgeon (Acipenser sinensis)., PMID:40328397
Targeting polyunsaturated fatty acids desaturase FADS1 inhibits renal cancer growth via ATF3-mediated ER stress response., PMID:40121894
The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation., PMID:40114193
[Molecular Mechanisms by Which Polyunsaturated Fatty Acids Suppress the Pathogenesis and Progression of NAFLD]., PMID:40024729
Causal association between polyunsaturated fatty acids and acne: a two-sample Mendelian randomization study., PMID:39936505
Genetically Predicted Gene Expression Effects on Changes in Red Blood Cell and Plasma Polyunsaturated Fatty Acids., PMID:39812514
FADS1 inhibition protects retinal pigment epithelium cells from ferroptosis in age related macular degeneration., PMID:39736411
Causal relationship between circulating plasma lipids and atopic dermatitis risk: potential drug targets and therapeutic strategies., PMID:39589539
Cardiometabolic risk factors are affected by interaction between FADS1 rs174556 variant and dietary vegetable oils in patients with diabetes: a randomized controlled trial., PMID:39528535
Co-Colorectal cancer stem cells employ the FADS1/DDA axis to evade NK cell-mediated immunosuppression after co-cultured with NK cells under hypoxia., PMID:39488917
FADS1 Genetic Variant and Omega-3 Supplementation Are Associated with Changes in Fatty Acid Composition in Red Blood Cells of Subjects with Obesity., PMID:39458515
Genetics of Calcific Aortic Stenosis: A Systematic Review., PMID:39457433
Ovarian multi-omics analysis reveals key rate-limiting enzymes FASN, SCD5, FADS1, 3BHSD, and STAR as potential targets for regulating kidding traits in goats., PMID:39433193
Serum metabonomics reveal the effectiveness of human placental mesenchymal stem cell therapy for primary sclerosing cholangitis., PMID:39380092
Recent advances on the physiological and pathophysiological roles of polyunsaturated fatty acids and their biosynthetic pathway., PMID:39326727
Thermal Adaptations in Animals: Genes, Development, and Evolution., PMID:39289287
Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet-An exploratory study., PMID:39218219
Genetic Features of Lipid and Carbohydrate Metabolism in Arctic Peoples., PMID:39218018
Association between thermogenic brown fat and genes under positive natural selection in circumpolar populations., PMID:39160621
ELOVL5 and VLDLR synergistically affect n-3 PUFA deposition in eggs of different chicken breeds., PMID:39018654
Functional Impact of the FADS1 rs174546 Single Nucleotide Polymorphism on Serum Lipid Levels: Insights from Molecular Mechanisms and Therapeutic Perspectives in Korean Population., PMID:38961528
Role of plasma fatty acid in age-related macular degeneration: insights from a mendelian randomization analysis., PMID:38951820
FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer., PMID:38926633
Fatty acid desaturase insertion-deletion polymorphism rs66698963 predicts colorectal polyp prevention by the n-3 fatty acid eicosapentaenoic acid: a secondary analysis of the seAFOod polyp prevention trial., PMID:38879016
High Frequency of Ancestral Haplotype A of Fatty Acid Desaturase Genes in the Yakut Population., PMID:38860387
Omega-3 fatty acids and major depression: a Mendelian randomization study., PMID:38811538
Hepatocyte-Specific Fads1 Overexpression Attenuates Western Diet-Induced Metabolic Phenotypes in a Rat Model., PMID:38732052
Dietary n-3 alpha-linolenic and n-6 linoleic acids modestly lower serum lipoprotein(a) concentration but differentially influence other atherogenic lipoprotein traits: A randomized trial., PMID:38714425
Targeted Knockdown of Hepatic Δ-5 Fatty Acid Desaturase FADS1 Aggravates Atherosclerosis in ApoE-/- Mice., PMID:38682200
Impact of FADS genotype on polyunsaturated fatty acid content in human milk extracellular vesicles: A genetic association study., PMID:38566550
Disruption of polyunsaturated fatty acid biosynthesis drives STING-dependent acute myeloid leukemia cell maturation and death., PMID:38522521
A Metabolome-Wide Mendelian Randomization Study Identifies Dysregulated Arachidonic Acid Synthesis as a Potential Causal Risk Factor for Bipolar Disorder., PMID:38401803
Fatty acid desaturase 1/2 (FADS1 and FADS2), fatty acid desaturase indices, and their relationships with metabolic syndrome in female adults with first-episode schizophrenia after antipsychotic medications., PMID:38394918
Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function., PMID:38316767
Gestational Diabetes Mellitus Remodels the Fetal Brain Fatty Acid Profile Through Placenta-Brain Lipid Axis in C57BL/6J Mice., PMID:38159812
A unique inflammation-related mechanism by which high-fat diets induce depression-like behaviors in mice., PMID:37437725
Investigating the role of FADS family members in breast cancer based on bioinformatic analysis and experimental validation., PMID:37122728
FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer., PMID:37041160
Interactions of genetic and macronutrient intake with abdominal obesity among middle-aged vegetarians in Malaysia., PMID:36997497
Fatty Acid Profile and Genetic Variants of Proteins Involved in Fatty Acid Metabolism Could Be Considered as Disease Predictor., PMID:36900123
Fetal Exposure to Endocrine Disrupting-Bisphenol A (BPA) Alters Testicular Fatty Acid Metabolism in the Adult Offspring: Relevance to Sperm Maturation and Quality., PMID:36835180
Lipid desaturation regulates the balance between self-renewal and differentiation in mouse blastocyst-derived stem cells., PMID:36477438
FADS cluster variants are associated with insulin sensitivity in children and adolescents with overweight and obesity., PMID:35906330
FADS1 and FADS2 as biomarkers of Zn status - a systematic review and meta-analysis., PMID:35880429
For research use only. Not for human or drug use.
