Catalog No.
YHA73401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val196-Gln380
Predicted molecular weight
23.28 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43639
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cytoplasmic protein NCK2, Growth factor receptor-bound protein 4, NCK adaptor protein 2, Nck-2, SH2/SH3 adaptor protein NCK-beta, NCK2, GRB4
Nck1 regulates the in vitro development of human regulatory T cells through AKT pathway., PMID:39963999
A novel function for α-synuclein as a regulator of NCK2 in olfactory bulb: implications for its role in olfaction., PMID:39543759
Adapting to change: resolving the dynamic and dual roles of NCK1 and NCK2., PMID:39392452
The causal relationship between plasma protein-to-protein ratios and type 2 diabetes and its complications: Proteomics mendelian randomization study., PMID:39021342
Regulation of RHOV signaling by interaction with SH3 domain-containing adaptor proteins and phosphorylation by PKA., PMID:38959529
KLF4 suppresses anticancer effects of brusatol via transcriptional upregulating NCK2 expression in melanoma., PMID:38583810
Impact of Maternal Mediterranean-Type Diet Adherence on Microbiota Composition and Epigenetic Programming of Offspring., PMID:38201877
Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects., PMID:37886469
Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects., PMID:37745545
Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development., PMID:37479911
OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility., PMID:37292517
Poor Prognostic Biomarker KIAA1522 Is Associated with Immune Infiltrates in Hepatocellular Carcinoma., PMID:36761433
[CBL inhibits proliferation and invasion of breast cancer cells by ubiquitylation-mediated degradation of NCK2]., PMID:36504051
Cardio-omentopexy requires a cardioprotective innate immune response to promote myocardial angiogenesis in mice., PMID:36004249
Complementary Nck1/2 Signaling in Podocytes Controls α Actinin-4-Mediated Actin Organization, Adhesion, and Basement Membrane Composition., PMID:35906089
Challenge accepted: uncovering the role of rare genetic variants in Alzheimer's disease., PMID:35000612
Gut microbiome features associated with liver fibrosis in Hispanics, a population at high risk for fatty liver disease., PMID:34633706
Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK Signaling., PMID:34606829
Nck adaptors at a glance., PMID:34558601
Proximity-Dependent Biotinylation to Elucidate the Interactome of TNK2 Nonreceptor Tyrosine Kinase., PMID:34428048
Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology., PMID:34124074
Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling., PMID:33917227
Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes., PMID:33589840
Overactivated Cdc42 acts through Cdc42EP3/Borg2 and NCK to trigger DNA damage response signaling and sensitize cells to DNA-damaging agents., PMID:32739212
Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability., PMID:32468886
Selective role of Nck1 in atherogenic inflammation and plaque formation., PMID:32427580
Characterisation of the biochemical and cellular roles of native and pathogenic amelogenesis imperfecta mutants of FAM83H., PMID:32289446
PLCE1 regulates the migration, proliferation, and differentiation of podocytes., PMID:32238860
Multivalent nephrin-Nck interactions define a threshold for clustering and tyrosine-dependent nephrin endocytosis., PMID:31974115
Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion., PMID:31638742
Association of HK2 and NCK2 with normal-tension glaucoma in a population from the Republic of Korea., PMID:31512042
Aristolochic acid inhibits Slit2-induced migration and tube formation via inactivation of Robo1/Robo2-NCK1/NCK2 signaling pathway in human umbilical vein endothelial cells., PMID:30381256
NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy., PMID:30150707
Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function., PMID:30089263
Nck2 is essential for limb trajectory selection by spinal motor axons., PMID:30016580
Proteomic Analysis of NCK1/2 Adaptors Uncovers Paralog-specific Interactions That Reveal a New Role for NCK2 in Cell Abscission During Cytokinesis., PMID:30002203
Gene expression profiles of CD4/CD8 double-positive T cells in porcine peripheral blood., PMID:29740910
Identification of crucial genes associated with Parkinson's disease using microarray data., PMID:29257331
Non-catalytic region of tyrosine kinase adaptor protein 2 (NCK2) pathways as factor promoting aggressiveness in ovarian cancer., PMID:29218693
Cyclic stretch-induced the cytoskeleton rearrangement and gene expression of cytoskeletal regulators in human periodontal ligament cells., PMID:28681629
Nck2, an unexpected regulator of adipogenesis., PMID:28425845
A Study of Interleukin-2 Production and Nck Adaptor Molecule Gene Expression in Systemic Lupus Erythematosus Patients., PMID:29911835
AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc-Based Protein-Fragment Complementation Assay., PMID:28087810
Angiotensin II increases glomerular permeability by β-arrestin mediated nephrin endocytosis., PMID:28004760
Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport., PMID:27615514
Signaling via PINCH: Functions, binding partners and implications in human diseases., PMID:27590440
Nck2 Deficiency in Mice Results in Increased Adiposity Associated With Adipocyte Hypertrophy and Enhanced Adipogenesis., PMID:27325288
Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP., PMID:27033705
Podocyte biology: Phosphorylation preserves podocytes., PMID:26923206
Nephrin Tyrosine Phosphorylation Is Required to Stabilize and Restore Podocyte Foot Process Architecture., PMID:26802179
For research use only. Not for human or drug use.
