Catalog No.
YHA68301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg37-Asn356
Predicted molecular weight
37.68 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43488
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Aflatoxin B1 aldehyde reductase member 2, 1.1.1.n11, AFB1 aldehyde reductase 1, AFB1-AR 1, Aldoketoreductase 7, Succinic semialdehyde reductase, SSA reductase, AKR7A2, AFAR, AFAR1, AKR7
Dealing with aflatoxin B1 dihydrodiol acute effects: Impact of aflatoxin B1-aldehyde reductase enzyme activity in poultry species tolerant to AFB1 toxic effects., PMID:32569334
Insights into the transcriptional regulation of the anthracycline reductase AKR7A2 in human cardiomyocytes., PMID:30817976
Inverse Molecular Docking as a Novel Approach to Study Anticarcinogenic and Anti-Neuroinflammatory Effects of Curcumin., PMID:30567342
Effects of dietary Allium hookeri root on growth performance and antioxidant activity in young broiler chickens., PMID:29635171
The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner., PMID:28536627
Alterations in gene expression after gamma-hydroxybutyric acid intake-A pilot study., PMID:28534145
Development of a CART Model to Predict the Synthesis of Cardiotoxic Daunorubicinol in Heart Tissue Samples From Donors With and Without Down Syndrome., PMID:27112290
Role of DNA Methylation on the Expression of the Anthracycline Metabolizing Enzyme AKR7A2 in Human Heart., PMID:25962911
Metabolism of bupropion by carbonyl reductases in liver and intestine., PMID:25904761
Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2., PMID:25451587
GST-M1 is transcribed moreso than AKR7A2 in AFB₁-exposed human monocytes and lymphocytes., PMID:25027672
Interindividual variability in the cardiac expression of anthracycline reductases in donors with and without Down syndrome., PMID:24562808
Trp266 determines the binding specificity of a porcine aflatoxin B₁ aldehyde reductase for aflatoxin B₁-dialdehyde., PMID:24008121
Effect of the combined probiotics with aflatoxin B₁-degrading enzyme on aflatoxin detoxification, broiler production performance and hepatic enzyme gene expression., PMID:23831311
Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases., PMID:22964423
Influence of broccoli extract and various essential oils on performance and expression of xenobiotic- and antioxidant enzymes in broiler chickens., PMID:22085616
Human aldo-keto reductase AKR7A2 protects against the cytotoxicity and mutagenicity of reactive aldehydes and lowers intracellular reactive oxygen species in hamster V79-4 cells., PMID:22001351
Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin., PMID:20837989
Proteomic analysis of urine in rats chronically exposed to fluoride., PMID:20665605
Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma., PMID:19077459
Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells., PMID:18752886
Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry., PMID:18266327
Prevalidation of potential protein biomarkers in toxicology using iTRAQ reagent technology., PMID:17443845
Multiplicity of mammalian reductases for xenobiotic carbonyl compounds., PMID:16547389
The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism., PMID:15769597
In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat., PMID:14988420
Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue., PMID:14656948
Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells., PMID:12879023
Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter., PMID:12727802
Mechanisms of protection against aflatoxin B(1) genotoxicity in rats treated by organosulfur compounds from garlic., PMID:12151352
Biochemical factors underlying the age-related sensitivity of turkeys to aflatoxin B(1)., PMID:12106896
Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins., PMID:12071861
Carbohydrate handling enzymes in fetal Down syndrome brain., PMID:11771744
Elevation of AKR7A2 (succinic semialdehyde reductase) in neurodegenerative disease., PMID:11597610
Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione., PMID:11471548
Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases., PMID:11409944
Androgen-regulated expression of a novel member of the aldo-keto reductase superfamily in regrowing rat prostate., PMID:10965890
Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver., PMID:10706111
Cloning and expression of succinic semialdehyde reductase from human brain. Identity with aflatoxin B1 aldehyde reductase., PMID:10518801
Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members., PMID:10510318
Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells., PMID:9823300
Chemoprevention of aflatoxin B1-induced carcinogenesis by indole-3-carbinol in rat liver--predicting the outcome using early biomarkers., PMID:9806166
Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1., PMID:9679543
Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase., PMID:9576847
Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism., PMID:9328168
Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin., PMID:9331086
A new nomenclature for the aldo-keto reductase superfamily., PMID:9310340
Isolation of cDNAs representing dithiolethione-responsive genes., PMID:8968041
Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors., PMID:8665510
Substrate specificity of an aflatoxin-metabolizing aldehyde reductase., PMID:8526867
For research use only. Not for human or drug use.
