Catalog No.
YHA65001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-His174
Predicted molecular weight
21.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43324
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Eukaryotic translation elongation factor 1 epsilon-1, Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3, Elongation factor p18, Multisynthase complex auxiliary component p18, EEF1E1, AIMP3, P18
Phase separation of EEF1E1 promotes tumor stemness via PTEN/AKT-mediated DNA repair in hepatocellular carcinoma., PMID:39884379
High-Intensity Interval Training Mitigates Sarcopenia and Suppresses the Myoblast Senescence Regulator EEF1E1., PMID:39276001
Identification and Mendelian randomization validation of pathogenic gene biomarkers in obstructive sleep apnea., PMID:39220737
EEF1E1 promotes glioma proliferation by regulating cell cycle through PTEN/AKT signaling pathway., PMID:37589446
Establishment and verification of a prognostic model of liver cancer by RNA-binding proteins based on the TCGA database., PMID:36249884
A Novel HCC Prognosis Predictor EEF1E1 Is Related to Immune Infiltration and May Be Involved in EEF1E1/ATM/p53 Signaling., PMID:34282404
Structural basis for the dynamics of human methionyl-tRNA synthetase in multi-tRNA synthetase complexes., PMID:34086935
AIMP3 inhibits cell growth and metastasis of lung adenocarcinoma through activating a miR-96-5p-AIMP3-p53 axis., PMID:33538115
Data article on genes that share similar expression patterns with EEF1 complex proteins in hepatocellular carcinoma., PMID:32025546
Alterations in Eukaryotic Elongation Factor complex proteins (EEF1s) in cancer and their implications in epigenetic regulation., PMID:31639400
Reference genes selection for real-time quantitative PCR analysis in mouse germinal vesicle oocytes., PMID:31544726
Symmetric Assembly of a Decameric Subcomplex in Human Multi-tRNA Synthetase Complex Via Interactions between Glutathione Transferase-Homology Domains and Aspartyl-tRNA Synthetase., PMID:31473157
Screening of underlying genetic biomarkers for ankylosing spondylitis., PMID:31059041
TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2., PMID:30858199
Upregulation of Proteolytic Pathways and Altered Protein Biosynthesis Underlie Retinal Pathology in a Mouse Model of Alzheimer's Disease., PMID:30707393
HIF1α-mediated AIMP3 suppression delays stem cell aging via the induction of autophagy., PMID:30706629
AIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in Mice., PMID:30302025
The expression profile and prognostic significance of eukaryotic translation elongation factors in different cancers., PMID:29342219
Mapping the contact surfaces in the Lamin A:AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry., PMID:28797100
Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor-Suppressive Interaction with Smurf2., PMID:27197155
Genetic variants in multisynthetase complex genes are associated with DNA damage levels in Chinese populations., PMID:26871430
Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains., PMID:26472928
Stepping Out of the Cytosol: AIMp1/p43 Potentiates the Link Between Innate and Adaptive Immunity., PMID:26325028
miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18., PMID:25465621
Loss of expression of the tumour suppressor gene AIMP3 predicts survival following radiotherapy in muscle-invasive bladder cancer., PMID:24917520
Optimisation of reference genes for gene-expression analysis in a rabbit model of left ventricular diastolic dysfunction., PMID:24558494
Identification of two novel BRCA1-partner genes in the DNA double-strand break repair pathway., PMID:24104880
Contributions of aminoacyl-tRNA synthetase-interacting multifunctional protein-3 to mammalian translation initiation., PMID:23306449
Taking AIM at the start of translation., PMID:22925579
AIMP3/p18 controls translational initiation by mediating the delivery of charged initiator tRNA to initiation complex., PMID:22867704
Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3., PMID:22106287
Expression of AIMP1, 2 and 3, the scaffolds for the multi-tRNA synthetase complex, is downregulated in gastric and colorectal cancer., PMID:21789020
Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease., PMID:21209200
Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice., PMID:20726853
Absence of somatic mutation of a tumor suppressor gene eukaryotic translation elongation factor 1, epsilon-1 (EEF1E1), in common human cancers., PMID:19024604
Expression profiles of the pluripotency marker gene POU5F1 and validation of reference genes in rabbit oocytes and preimplantation stage embryos., PMID:18662377
Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM., PMID:18343821
Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes., PMID:18175754
For research use only. Not for human or drug use.
