Catalog No.
YHA60001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr45-Pro107
Predicted molecular weight
35.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43186
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cone-rod homeobox protein, CRX, CORD2
Systematic review of genotype-phenotype associations in CRX-associated retinal dystrophies., PMID:40132901
Clinical Characteristics and Visual Prognostic Biomarkers in Pericentral Retinitis Pigmentosa: A Study in a South Korean Cohort., PMID:40007196
Enhanced Transcriptional Activation in Developing Mouse Photoreceptors., PMID:39854013
Integration of multiomic data identifies core-module of inherited-retinal diseases., PMID:39797395
Active learning of enhancers and silencers in the developing neural retina., PMID:39778579
Aberrant homeodomain-DNA cooperative dimerization underlies distinct developmental defects in two dominant CRX retinopathy models., PMID:39715683
Bifocal retinal degeneration observed on ultra-widefield autofluorescence in some cases of CRX-associated retinopathy., PMID:39632990
A DNA base-specific sequence interposed between CRX and NRL contributes to RHODOPSIN expression., PMID:39487168
Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain., PMID:39322280
Clinical, Genetic, and Histopathological Characteristics of CRX-associated Retinal Dystrophies., PMID:39128788
Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element., PMID:39084215
Atypic Retinitis Pigmentosa Clinical Features Associated with a Peculiar CRX Gene Mutation in Italian Patients., PMID:38792980
Transcriptional precision in photoreceptor development and diseases - Lessons from 25 years of CRX research., PMID:38414750
Pathogenic variants in CRX have distinct cis-regulatory effects on enhancers and silencers in photoreceptors., PMID:38355306
CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoids., PMID:38049871
Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms., PMID:37963072
Gene Augmentation for Autosomal Dominant CRX-Associated Retinopathies., PMID:37440026
Late-Onset Autosomal Dominant Macular Degeneration Caused by Deletion of the CRX Gene., PMID:35934205
Interaction of human CRX and NRL in live HEK293T cells measured using fluorescence resonance energy transfer (FRET)., PMID:35484285
Structural and functional analysis of the human cone-rod homeobox transcription factor., PMID:35255174
Allele-specific gene editing to rescue dominant CRX-associated LCA7 phenotypes in a retinal organoid model., PMID:34653402
Poly ADP Ribose Polymerase Inhibitor Olaparib Targeting Microhomology End Joining in Retinoblastoma Protein Defective Cancer: Analysis of the Retinoblastoma Cell-Killing Effects by Olaparib after Inducing Double-Strand Breaks., PMID:34639028
Pineal gland differentiation in mature teratoma: An under-recognized condition and potential pitfalls for overdiagnosis., PMID:34473871
Downregulation of CRX, a Group 3-specific oncogenic transcription factor, inhibits TGF-β/activin signaling in medulloblastoma cells., PMID:34192607
Modeling Cone/Cone-Rod Dystrophy Pathology by AAV-Mediated Overexpression of Mutant CRX Protein in the Mouse Retina., PMID:34144598
Change of transcription level of photoreceptor-specific CRX gene in the peripheral blood of the participants of an arctic world oceanic international flight., PMID:33881257
Gene Therapy of Dominant CRX-Leber Congenital Amaurosis using Patient Stem Cell-Derived Retinal Organoids., PMID:33513359
IGFBPs mediate IGF-1's functions in retinal lamination and photoreceptor development during pluripotent stem cell differentiation to retinal organoids., PMID:33442906
Distantly Metastatic Retinoblastoma to Soft Tissue and Bone: A Challenging Diagnosis Highlighting the Utility of CRX., PMID:33165094
A mutation in CRX causing pigmented paravenous retinochoroidal atrophy., PMID:32927963
Analysis of Early Cone Dysfunction in an In Vivo Model of Rod-Cone Dystrophy., PMID:32842706
Heterozygous CRX R90W mutation-associated adult-onset macular dystrophy with phenotype analogous to benign concentric annular macular dystrophy., PMID:32689858
Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina., PMID:32631829
Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association., PMID:32533067
Crx Is Posttranscriptionally Regulated by Light Stimulation in Postnatal Rat Retina., PMID:32318566
Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development., PMID:31968244
Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types., PMID:31915147
A recurrent arcuate retinopathy in familial cone-rod dystrophy secondary to heterozygous CRX deletion., PMID:31743059
Pathogenicity discrimination and genetic test reference for CRX variants based on genotype-phenotype analysis., PMID:31626798
Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish., PMID:31602413
Of eyes and embryos: subfunctionalization of the CRX homeobox gene in mammalian evolution., PMID:31337308
Generation of a human iPSC line, INMi004-A, with a point mutation in CRX associated with autosomal dominant Leber congenital amaurosis., PMID:31247521
Incomplete penetrance of CRX gene for autosomal dominant form of cone-rod dystrophy., PMID:31215831
Generation of a human iPSC line, INMi003-A, with a missense mutation in CRX associated with autosomal dominant cone-rod dystrophy., PMID:31203166
Genetically-modified human mesenchymal stem cells to express erythropoietin enhances differentiation into retinal photoreceptors: An in-vitro study., PMID:31060031
Retinal dystrophies with bull's-eye maculopathy along with negative ERGs., PMID:30945053
A case-control collapsing analysis identifies retinal dystrophy genes associated with ophthalmic disease in patients with no pathogenic ABCA4 variants., PMID:30926958
Simvastatin protects photoreceptors from oxidative stress induced by all-trans-retinal, through the up-regulation of interphotoreceptor retinoid binding protein., PMID:30825184
For research use only. Not for human or drug use.
