Catalog No.
YHA50101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser325-Arg508
Predicted molecular weight
22.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15355
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein phosphatase 1G, 3.1.3.16, Protein phosphatase 1C, Protein phosphatase 2C isoform gamma, PP2C-gamma, Protein phosphatase magnesium-dependent 1 gamma, PPM1G, PPM1C
PPM1G dephosphorylates α-catenin to maintain the integrity of adherens junctions and regulates apoptosis in Sertoli cells., PMID:39952314
PPM1G Inhibits Epithelial-Mesenchymal Transition in Cholangiocarcinoma by Catalyzing TET1 Dephosphorylation for Destabilization to Impair Its Targeted Demethylation of the CLDN3 Promoter., PMID:39477806
PPM1G-mediated TBL1X mRNA splicing promotes cell migration in hepatocellular carcinoma., PMID:39462759
Ubiquitin-related gene markers predict immunotherapy response and prognosis in patients with epithelial ovarian carcinoma., PMID:39448713
PPM1G and its diagnostic, prognostic and therapeutic potential in HCC (Review)., PMID:39329206
PPM1G promotes autophagy and progression of pancreatic cancer via upregulating HMGB1., PMID:39121976
PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferation., PMID:39111820
Biomarker discovery with quantum neural networks: a case-study in CTLA4-activation pathways., PMID:38609844
PPM1G promotes cell proliferation via modulating mutant GOF p53 protein expression in hepatocellular carcinoma., PMID:38384839
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages., PMID:38372470
Systemic inflammation and risk of Parkinson's disease: A prospective cohort study and genetic analysis., PMID:38336023
Prognostic and immunological potential of PPM1G in lung adenocarcinoma., PMID:37387407
Construction and validation of a prognostic model for hepatocellular carcinoma: Inflammatory ferroptosis and mitochondrial metabolism indicate a poor prognosis., PMID:36686830
PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6., PMID:36349938
Clinical Value of PPM1G Gene in Survival Prognosis and Immune Infiltration of Hepatocellular Carcinoma., PMID:35126665
High expression of PPM1G is associated with the progression and poor prognosis of hepatocellular carcinoma., PMID:34366322
PPM1G promotes the progression of hepatocellular carcinoma via phosphorylation regulation of alternative splicing protein SRSF3., PMID:34290239
Prognostic and immunological potential of PPM1G in hepatocellular carcinoma., PMID:33952716
Identification and validation of a five-gene prognostic signature for hepatocellular carcinoma., PMID:33771191
The ARF tumor suppressor targets PPM1G/PP2Cγ to counteract NF-κB transcription tuning cell survival and the inflammatory response., PMID:33288725
PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion., PMID:33219031
Protein expression profiles that underpin the preventive and therapeutic potential of Moringa oleifera Lam against azoxymethane and dextran sodium sulfate-induced mouse colon carcinogenesis., PMID:32724422
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors., PMID:32650009
Absence of miRNA-146a Differentially Alters Microglia Function and Proteome., PMID:32582192
Association of PPM1G methylation with risk-taking in alcohol use disorder., PMID:32218500
DNA methylation in the medial prefrontal cortex regulates alcohol-related behavior in rats., PMID:31956101
Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation., PMID:31621893
PPM1G forms a PPP-type phosphatase holoenzyme with B56δ that maintains adherens junction integrity., PMID:31432583
Genomic Integrity Safeguards Self-Renewal in Embryonic Stem Cells., PMID:31390555
Identification and Characterization of USP7 Targets in Cancer Cells., PMID:30367141
The Protein Phosphatase PPM1G Destabilizes HIF-1α Expression., PMID:30081604
Genetic Architecture of the Cardiovascular Risk Proteome., PMID:29258991
Two-Step Coimmunoprecipitation (TIP) Enables Efficient and Highly Selective Isolation of Native Protein Complexes., PMID:29217617
Regulation of p27Kip1 phosphorylation and G1 cell cycle progression by protein phosphatase PPM1G., PMID:27822412
Phosphatidylinositol-3 kinase-dependent translational regulation of Id1 involves the PPM1G phosphatase., PMID:27065332
Serine/threonine phosphatases and aquaporin-2 regulation in renal collecting duct., PMID:27784696
Phosphorylated TandeMBP: A unique protein substrate for protein phosphatase assay., PMID:27565380
Avirulence gene mapping in the Hessian fly (Mayetiola destructor) reveals a protein phosphatase 2C effector gene family., PMID:26439791
Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis., PMID:26392083
PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation., PMID:26324325
tert-Butylhydroquinone mobilizes intracellular-bound zinc to stabilize Nrf2 through inhibiting phosphatase activity., PMID:25994789
Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis., PMID:25982659
The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor., PMID:25631048
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study., PMID:25604533
The catalytically inactive tyrosine phosphatase HD-PTP/PTPN23 is a novel regulator of SMN complex localization., PMID:25392300
Protein Phosphatase 2C of Toxoplasma Gondii Interacts with Human SSRP1 and Negatively Regulates Cell Apoptosis., PMID:25374021
WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels., PMID:25071155
PPM1B depletion induces premature senescence in human IMR-90 fibroblasts., PMID:24674756
Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction., PMID:24390428
Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation., PMID:24316072
For research use only. Not for human or drug use.
