Catalog No.
YHA32501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
[Glu65-Cys79] & [Gly143-Ser178] & [Cys201-Ala223] & [Gly280-Lys300]
Predicted molecular weight
25.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14842
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Free fatty acid receptor 1, G-protein coupled receptor 40, FFAR1, GPR40
Fatty Acid Taste Quality Information via GPR40 and CD36 in the Posterior Tongue of Mice., PMID:40511690
Activation fingerprints and allosteric modulation at the free fatty acid receptor 1 (FFAR1) revealed by molecular dynamics simulation., PMID:40409391
GPR40 activation alleviates pulmonary fibrosis by repressing M2 macrophage polarization through the PKD1/CD36/TGF-β1 pathway., PMID:40369224
A novel free fatty acid receptor agonist improving metabolic health in Drosophila models., PMID:40348099
GPR40 signaling in agouti-related peptide neurons mediates fat preference., PMID:40320138
GPR40 inhibits microglia-mediated neuroinflammation via the NLRP3/IL-1β/glutaminase pathway after subarachnoid hemorrhage., PMID:40318813
Discovery of ZYDG2: A potent, selective, and safe GPR40 agonist for treatment of type 2 diabetes., PMID:40158321
Discovery of potent free fatty acid receptor 1 full agonists with a novel scaffold bearing conjugated double bond linker., PMID:40139045
Pharmacological and resting state fMRI reveal Osteocalcin's effects on mouse brain regions with high Gpr37 and Gpr158 expression., PMID:40128223
Oleic acid enhances the proliferation of gallbladder cancer cells via the GPR120/ERK pathway., PMID:40023990
[Effect of Yuxuebi Tablets on mice with inflammatory pain based on GPR37-mediated inflammation resolution]., PMID:39929659
Metabolite-Sensing Receptors: Emerging Targets for Modulating Chronic Pain Pathways., PMID:39852178
Recent Developments in Drug Design of Oral Synthetic Free Fatty Acid Receptor 1 Agonists., PMID:39679134
Single-cell transcriptomics of human organoid-derived enteroendocrine cell populations from the small intestine., PMID:39639676
Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1 and FFAR2., PMID:39616615
Unveiling the biological activities of the microbial long chain hydroxy fatty acids as dual agonists of GPR40 and GPR120., PMID:39556901
A non-canonical mechanism of GPCR activation., PMID:39550377
Lower hepatotoxicity risk in Xelaglifam, a novel GPR40 agonist, compared to Fasiglifam for type 2 diabetes therapy., PMID:39536537
Anti-Inflammatory and Antinociceptive Properties of the Quercetin-3-Oleate AV2, a Novel FFAR1 Partial Agonist., PMID:39519187
The Role of miR-155 in Modulating Gene Expression in CD4+ T Cells: Insights into Alternative Immune Pathways in Autoimmune Encephalomyelitis., PMID:39518908
[A long chain fatty acid receptor signaling as a new therapeutic target for stress-induced chronic pain]., PMID:39496406
Molecular mechanisms underlying glucose-dependent insulinotropic polypeptide secretion in human duodenal organoids., PMID:39441374
Synthetic free fatty acid receptor (FFAR) 2 agonist 4-CMTB and FFAR4 agonist GSK13764 inhibit colon cancer cell growth and migration and regulate FFARs expression in in vitro and in vivo models of colorectal cancer., PMID:39432182
Enteroendocrine cell-derived peptide YY signalling is stimulated by pinolenic acid or Intralipid and involves coactivation of fatty acid receptors FFA1, FFA4 and GPR119., PMID:39427565
A computational and machine learning approach to identify GPR40-targeting agonists for neurodegenerative disease treatment., PMID:39378198
Renal Protection of HWL-088and ZLY-032, Two Dual GPR40/PPARδ Agonists, in Adenine-Induced Renal Fibrosis Model., PMID:39376036
N-acyl glycines produced by commensal bacteria potentiate GLP-1 secretion as GPCR ligands., PMID:39362066
GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson's disease animal models., PMID:39313081
Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity., PMID:39309505
GPR40/GPR120 Agonist GW9508 Improves Metabolic Syndrome-Exacerbated Periodontitis in Mice., PMID:39273569
Effect of hypoxia on GLP-1 secretion - an in vitro study using enteroendocrine STC-1 -cells as a model., PMID:39075239
Mitochondria to plasma membrane redox signaling is essential for fatty acid β-oxidation-driven insulin secretion., PMID:39067330
Influence of the Water Model on the Structure and Interactions of the GPR40 Protein with the Lipid Membrane and the Solvent: Rigid versus Flexible Water Models., PMID:38991114
FFAR-mediated signaling drives migration of pancreatic cancer cells in hypoxic fibroblast co-cultures., PMID:38945064
Xelaglifam, a novel GPR40/FFAR1 agonist, exhibits enhanced β-arrestin recruitment and sustained glycemic control for type 2 diabetes., PMID:38941892
Chronic administration of hydrolysed pine nut oil to mice improves insulin sensitivity and glucose tolerance and increases energy expenditure via a free fatty acid receptor 4-dependent mechanism., PMID:38751244
Gene expression of free fatty acids-sensing G protein-coupled receptors in beef cattle., PMID:38659415
trans-Palmitoleic acid promotes adipose thermogenesis to reduce obesity via hypothalamic FFAR1 signaling., PMID:38592736
The GPR40 novel agonist SZZ15-11 improves non-alcoholic fatty liver disease by activating the AMPK pathway and restores metabolic homeostasis in diet-induced obese mice., PMID:38497233
GW9508 ameliorates cognitive dysfunction via autophagy pathway in streptozotocin-induced mouse model of Alzheimer's disease., PMID:38486405
Activation of free fatty acid receptors, FFAR1 and FFAR4, ameliorates ulcerative colitis by promote fatty acid metabolism and mediate macrophage polarization., PMID:38432147
Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment., PMID:38361249
Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte., PMID:38339087
The role of free fatty acid receptor-1 in gastric contractions in Suncus murinus., PMID:38318756
Effects of free fatty acid receptor (FFAR) signaling on the modulation of cancer cell functions under hypoxic conditions., PMID:38280308
First-in-human study of CPL207280, a novel G-protein-coupled receptor 40/free fatty acid receptor 1 agonist, in healthy volunteers after single and multiple administration., PMID:38204407
Synthetic GPR40/FFAR1 agonists: An exhaustive survey on the most recent chemical classes and their structure-activity relationships., PMID:38039791
Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance., PMID:38036170
An updated patent review of GPR40/ FFAR1 modulators (2020 - present)., PMID:37947382
Effect of pregnancy on the expression of nutrient-sensors and satiety hormones in mice., PMID:37926186
For research use only. Not for human or drug use.
