Catalog No.
YHA28601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ala116
Predicted molecular weight
14.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14745
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Na(+)/H(+) exchange regulatory cofactor NHE-RF1, NHERF-1, Ezrin-radixin-moesin-binding phosphoprotein 50, EBP50, Regulatory cofactor of Na(+)/H(+) exchanger, Sodium-hydrogen exchanger regulatory factor 1, Solute carrier family 9 isoform A3 regulatory factor 1, NHERF1, NHERF, SLC9A3R1
Optimizing Detection of Circulating Tumor Cells in Breast Cancer: Unveiling New Markers for Clinical Applications., PMID:40429857
Erbin interacts with NHERF1 and Ezrin to stabilize a membrane ErbB2 signaling complex in HER2-positive breast cancer., PMID:40390040
Congenital enteropathy caused by ezrin deficiency., PMID:40137958
Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes., PMID:40063811
EBP50 regulates senescence and focal adhesion in endometrial carcinoma., PMID:39971177
NHERF2 as a Novel Biomarker for Distinguishing MAC Pulmonary Disease from Tuberculosis Based on Proteome Analysis of Serum Extracellular Vesicles., PMID:39940923
Noncanonical RGS14 structural determinants control hormone-sensitive NPT2A-mediated phosphate transport., PMID:39792018
Astrocytic NHERF-1 Increases Seizure Susceptibility by Inhibiting Surface Expression of TREK-1., PMID:39543986
Proteomic Characterization of Urinary Exosomes with Pancreatic Cancer by Phosphatidylserine Imprinted Polymer Enrichment and Mass Spectrometry Analysis., PMID:39392357
Role of NHERF1 in MicroRNA Landscape Changes in Aging Mouse Kidneys., PMID:39334814
Sirtuin 1-mediated autophagy regulates testosterone synthesis in Leydig cells of piglets., PMID:39298912
Distinct and overlapping RGS14 and RGS12 actions regulate NPT2A-mediated phosphate transport., PMID:39293332
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin., PMID:38597186
Genetic profile of a large Spanish cohort with hypercalcemia., PMID:38586466
cGMP-dependent kinase 2, Na+/H+ exchanger NHE3, and PDZ-adaptor NHERF2 co-assemble in apical membrane microdomains., PMID:38533975
Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice., PMID:37972265
EBP50 is a key molecule for the Schwann cell-axon interaction in peripheral nerves., PMID:37940033
A maturational shift in the frontal cortex synaptic transcriptional landscape underlies schizophrenia-relevant behavioural traits: A congenital rat model., PMID:37263043
Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia., PMID:37132631
Proteomic profiling of cutaneous melanoma explains the aggressiveness of distant organ metastasis., PMID:37082900
Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport causing congenital hypophosphatemia., PMID:36945373
Prognostic 7-SLC-Gene Signature Identified via Weighted Gene Co-Expression Network Analysis for Patients with Hepatocellular Carcinoma., PMID:36844876
High frequency of heterozygous rare variants of the SLC34A1 and SLC9A3R1 genes in patients with atypical femur fracture., PMID:36762943
Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration., PMID:36604669
Relationship between clinical phenotype and in vitro analysis of 13 NPT2c/SCL34A3 mutants., PMID:36596813
The Analysis of the Ubiquitylomic Responses to Streptococcus agalactiae Infection in Bovine Mammary Gland Epithelial Cells., PMID:35923910
Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na+/H+ Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway., PMID:35674015
Involvement of RUVBL1 in WNT/β-Catenin Signaling in Oral Squamous Cell Carcinoma., PMID:35493294
RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein., PMID:35307350
PPAR-α knockout leads to elevated blood pressure response to angiotensin II infusion associated with an increase in renal α-1 Na+/K+ ATPase protein expression and activity., PMID:35245523
Cotranslational interaction of human EBP50 and ezrin overcomes masked binding site during complex assembly., PMID:35140182
MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells., PMID:34965434
PDZ-Containing Proteins Targeted by the ACE2 Receptor., PMID:34835087
Overlapping Phenotypes Associated With CYP24A1, SLC34A1, and SLC34A3 Mutations: A Cohort Study of Patients With Hypersensitivity to Vitamin D., PMID:34721296
Scaffolding proteins in pediatric glioma., PMID:34705668
Pan-Cancer Analysis Reveals Common and Specific Relationships between Intragenic miRNAs and Their Host Genes., PMID:34572448
A novel mutation in collagen gene COL1A2 associated with transient regional osteoporosis., PMID:34463844
Cytoplasmic EBP50 and elevated PARP1 are unfavorable prognostic factors in ovarian clear cell carcinoma., PMID:34323956
NHERF4 hijacks Mas-mediated PLC/AKT signaling to suppress the invasive potential of clear cell renal cell carcinoma cells., PMID:34216689
Akt scaffold proteins: the key to controlling specificity of Akt signaling., PMID:34161152
Lack of CFTR alters the ferret pancreatic ductal epithelial secretome and cellular proteome: Implications for exocrine/endocrine signaling., PMID:34016558
Nuclear expression of NHERF1/EBP50 in Clear Cell Renal Cell Carcinoma., PMID:33965858
Na+/H+ Exchanger Regulatory Factor 1 Mediates the Pathogenesis of Airway Inflammation in a Murine Model of House Dust Mite-Induced Asthma., PMID:33952618
Multiomics Investigation of Hypertension and White Matter Hyperintensity as a Source of Vascular Dementia or a Comorbidity to Alzheimer's Disease., PMID:33888050
Nephrin-Ephrin-B1-Na+/H+ Exchanger Regulatory Factor 2-Ezrin-Actin Axis Is Critical in Podocyte Injury., PMID:33887216
Integrin-Linked Kinase Links Integrin Activation to Invadopodia Function and Invasion via the p(T567)-Ezrin/NHERF1/NHE1 Pathway., PMID:33671549
Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport., PMID:33639163
Noncanonical Sequences Involving NHERF1 Interaction with NPT2A Govern Hormone-Regulated Phosphate Transport: Binding Outside the Box., PMID:33499384
A Critical Role for Na+/H+ Exchanger Regulatory Factor 1 in Modulating FcεRI-Mediated Mast Cell Activation., PMID:33361207
Cyclic Peptidyl Inhibitors against CAL/CFTR Interaction for Treatment of Cystic Fibrosis., PMID:33314931
For research use only. Not for human or drug use.
